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Q32KR6 (FDFT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Squalene synthase

Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Gene names
Name:FDFT1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway By similarity.

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Squalene synthase
PRO_0000290005

Regions

Transmembrane284 – 30421Helical; Potential
Transmembrane384 – 40421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q32KR6 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: C6A2FD8EA5C85BC7

FASTA41748,304
        10         20         30         40         50         60 
MEFVKCLGHP EEFYNLLRFQ MGGRRKVIPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA 

        70         80         90        100        110        120 
LDGEMRHAVC IFYLVLRALD TLEDDMTISI ERKVPLLHNF HSYLYEPDWR FTESKEKDRQ 

       130        140        150        160        170        180 
VLEDFPTISL EFRNLAEKYQ TVIVDVCQKM GFGMAEFLDK RVTSEREWDK YCHYVAGLVG 

       190        200        210        220        230        240 
IGLSRLFPAS ELEDPLIGED TERANSMGLF LQKTNIIRDY LEDQREGREF WPQETWSKYV 

       250        260        270        280        290        300 
KKLGDFAKPE NIDLAVQCLN ELITNTLHHI PDVITYLSRL RNQSIFNFCA IPQVMAIATL 

       310        320        330        340        350        360 
AACYNNQQVF KGVVKIRKGQ AVTLMMDATN MPAVKAIIHQ YMEEIYHRIP NSDPCSTKTQ 

       370        380        390        400        410 
QIISTIRTQN LPNCQLVSRS HYSPIYLSFV MLLAALSWQY LSTLSQVTED YVQTGEH 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC109959 mRNA. Translation: AAI09960.1.
UniGeneBt.14255.

3D structure databases

ProteinModelPortalQ32KR6.
SMRQ32KR6. Positions 38-370.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000016504.

Proteomic databases

PRIDEQ32KR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1562.
HOGENOMHOG000186940.
HOVERGENHBG002370.
InParanoidQ32KR6.

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_BOVIN
AccessionPrimary (citable) accession number: Q32KR6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways