Q32KN2 (BNIP3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene names

Name:

BNIP3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 By similarity.
Subunit structure	Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2 By similarity.
Subcellular location	Mitochondrion By similarity. Mitochondrion membrane; Single-pass membrane protein By similarity. Note: Colocalizes with ACAA2 in the mitochondria By similarity.
Sequence similarities	Belongs to the NIP3 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3		PRO_0000269189
Regions
	Transmembrane	166 – 186	21	Helical; Potential
Amino acid modifications
	Modified residue	86	1	Phosphoserine By similarity
	Modified residue	92	1	Phosphoserine By similarity
	Modified residue	93	1	Phosphoserine By similarity
	Modified residue	95	1	Phosphoserine By similarity
	Modified residue	99	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q32KN2 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 0AB2E1AFFEC2AC1C	FASTA	196	21,886
	10 20 30 40 50 60 MSQSESPGLQ EESLHGSWVE LHFGSNGNGS SVPDSVSIYK GDMEKILLDA QHESGRSSSK 70 80 90 100 110 120 SSHCDSPPRS QTPQDTNRAS ETDTHSLGEK NSSQSEEDYM ERRKEVESIL KKNSDWIWDW 130 140 150 160 170 180 SSRPENVPPA KEFLLFKHPK RTPTLSMRNT SVMKKGGIFS AEFLKVFLPS LLLSHLLAIG 190 LGIYIGRRLT TSTSTF

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC110012 mRNA. Translation: AAI10013.1.
IPI	IPI00709290.
RefSeq	NP_001069834.1. NM_001076366.1.
UniGene	Bt.1411.
3D structure databases
ProteinModelPortal	Q32KN2.
SMR	Q32KN2. Positions 148-192.
ModBase	Search...
Protein-protein interaction databases
STRING	Q32KN2.
Proteomic databases
PRIDE	Q32KN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	615342.
KEGG	bta:615342.
Organism-specific databases
CTD	664.
Phylogenomic databases
eggNOG	maNOG17367.
GeneTree	ENSGT00390000013415.
HOVERGEN	HBG050707.
InParanoid	Q32KN2.
OrthoDB	EOG4T784H.
Family and domain databases
InterPro	IPR010548. BNIP3. [Graphical view]
KO	K15464.
Pfam	PF06553. BNIP3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BNIP3_BOVIN

Accession

Primary (citable) accession number: Q32KN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 6, 2005
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program