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Protein

Arylsulfatase G

Gene

Arsg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44CalciumBy similarity1
Metal bindingi45CalciumBy similarity1
Active sitei84NucleophileBy similarity1
Metal bindingi84Calcium; via 3-oxoalanineBy similarity1
Binding sitei137SubstrateBy similarity1
Active sitei139By similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi302CalciumBy similarity1
Metal bindingi303CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
R-RNO-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase G (EC:3.1.6.-)
Short name:
ASG
Gene namesi
Name:Arsg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306571 Arsg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000023866417 – 526Arylsulfatase GAdd BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei843-oxoalanine (Cys)By similarity1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ32KJ9
PRIDEiQ32KJ9

PTM databases

PhosphoSitePlusiQ32KJ9

Expressioni

Gene expression databases

BgeeiENSRNOG00000003931
GenevisibleiQ32KJ9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005257

Structurei

3D structure databases

ProteinModelPortaliQ32KJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiQ32KJ9
KOiK12381
OMAiKAFYITG
OrthoDBiEOG091G041Y
PhylomeDBiQ32KJ9
TreeFamiTF314186

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32KJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLFLKVLL VGMVFSGLLY PFVDFSISGE TRAPRPNIVI ILADDMGWGD
60 70 80 90 100
LGANWAETKD TTNLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN
110 120 130 140 150
GVTHNFAVTS VGGLPLNETT LAEVLQQAGY VTAMIGKWHL GHHGSYHPSF
160 170 180 190 200
RGFDYYFGIP YSNDMGCTDN PGYNYPPCPA CPQSDGRWRN PDRDCYTDVA
210 220 230 240 250
LPLYENLNIV EQPVNLSGLA QKYAERAVEF IEQASTSGRP FLLYVGLAHM
260 270 280 290 300
HVPLSVTPPL ANPQSQRLYR ASLQEMDSLV GQIKDKVDHV AKENTLLWFA
310 320 330 340 350
GDNGPWAQKC ELAGSMGPFS GLWQTHQGGS PAKQTTWEGG HRVPALAYWP
360 370 380 390 400
GRVPVNVTST ALLSLLDIFP TVIALAGASL PPNRKFDGVD VSEVLFGKSQ
410 420 430 440 450
TGHRVLFHPN SGAAGEYGAL QTVRLDRYKA FYITGGAKAC DGGVGPEQHH
460 470 480 490 500
VSPLIFNLED DAAESSPLQK GSPEYQELLP KVTRVLADVL QDIADDNSSQ
510 520
ADYTQDPSVT PCCNPYQITC RCQPGE
Length:526
Mass (Da):57,269
Last modified:December 6, 2005 - v1
Checksum:i95C5F00354AE84A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073953 Genomic DNA No translation available.
AABR03074766 Genomic DNA No translation available.
AABR03075952 Genomic DNA No translation available.
AABR03076519 Genomic DNA No translation available.
AABR03076696 Genomic DNA No translation available.
BN000738 mRNA Translation: CAI84984.1
RefSeqiNP_001041342.1, NM_001047877.1
XP_006247661.1, XM_006247599.3
XP_006247662.1, XM_006247600.3
XP_006247663.1, XM_006247601.3
XP_006247664.1, XM_006247602.3
XP_006247665.1, XM_006247603.2
XP_006247666.1, XM_006247604.3
XP_006247668.1, XM_006247606.3
XP_006247669.1, XM_006247607.3
XP_006247670.1, XM_006247608.3
XP_008766590.1, XM_008768368.2
XP_008766591.1, XM_008768369.1
UniGeneiRn.221856

Genome annotation databases

EnsembliENSRNOT00000005257; ENSRNOP00000005257; ENSRNOG00000003931
GeneIDi303631
KEGGirno:303631

Similar proteinsi

Entry informationi

Entry nameiARSG_RAT
AccessioniPrimary (citable) accession number: Q32KJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health