Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arylsulfatase K

Gene

Arsk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40CalciumBy similarity1
Active sitei80NucleophileBy similarity1
Metal bindingi80Calcium; via 3-oxoalanineBy similarity1
Binding sitei128SubstrateBy similarity1
Binding sitei249SubstrateBy similarity1
Metal bindingi311CalciumBy similarity1
Metal bindingi312CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
R-RNO-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase K (EC:3.1.6.-)
Short name:
ASK
Gene namesi
Name:Arsk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1310182 Arsk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000035628718 – 563Arylsulfatase KAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei803-oxoalanine (Cys)By similarity1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ32KJ2
PRIDEiQ32KJ2

Expressioni

Gene expression databases

BgeeiENSRNOG00000026937
GenevisibleiQ32KJ2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029855

Structurei

3D structure databases

ProteinModelPortaliQ32KJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3731 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00730000110906
HOGENOMiHOG000034080
HOVERGENiHBG054703
InParanoidiQ32KJ2
KOiK12376
OMAiLSEYHGC
OrthoDBiEOG091G061W
PhylomeDBiQ32KJ2

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32KJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLVSVIV ALALVAPAPE TQEKRLQVAQ APNVVLVASD SFDGRLTFQP
60 70 80 90 100
GSQVVKLPFI NFMRARGTTF LNAYTNSPIC CPSRAAMWSG LFTHLTESWN
110 120 130 140 150
NFKGLDPNYT TWMDVMEKHG YQTQKFGKLD YSSGHHSISN RVEAWTRDVA
160 170 180 190 200
FLLRQEGRPI INLIPDKNRR RVMDKDWQNT DKAIAWLRQV NSTKPFVLYL
210 220 230 240 250
GLNLPHPYPS PSSGENFGSS TFHTSLYWLE KVAYDAIKIP KWLALSEMHP
260 270 280 290 300
VDYYSSYTKN CTGKFTENEI KNIRAFYYAM CAETDAMLGE IILALHKLNL
310 320 330 340 350
LQKTIVIYTS DHGEMAMEHR QFYKMSMYEA SAHVPILMMG PGIKANLQVP
360 370 380 390 400
SLVSLVDIYP TMLDIAGIPL PLNLSGYSLL PLSSNTSAND QAFRVHHPPW
410 420 430 440 450
ILSEFHGCNA NASTYMLRTG QWKYIAYSDG TLVQPQLFDL SLDPDELTNI
460 470 480 490 500
ATEFPEITYS LDQQLRSVIN YPKVSASVHR YNKEQFIMWK QSVAQNYSNY
510 520 530 540 550
IAHLRWHQDW QKDPRKYENA IQRWLAIHSS PPTHSPLSLV HQWLTTHSSP
560
IAVDNKKTFS SYT
Length:563
Mass (Da):64,273
Last modified:December 6, 2005 - v1
Checksum:i1B784F33678AC5A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012430 Genomic DNA No translation available.
AABR03016345 Genomic DNA No translation available.
AABR03016385 Genomic DNA No translation available.
BN000745 mRNA Translation: CAI84991.1
RefSeqiNP_001041382.1, NM_001047917.1
UniGeneiRn.202360

Genome annotation databases

EnsembliENSRNOT00000029250; ENSRNOP00000029855; ENSRNOG00000026937
GeneIDi365619
KEGGirno:365619
UCSCiRGD:1310182 rat

Similar proteinsi

Entry informationi

Entry nameiARSK_RAT
AccessioniPrimary (citable) accession number: Q32KJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health