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Protein

Arylsulfatase G

Gene

ARSG

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44CalciumBy similarity1
Metal bindingi45CalciumBy similarity1
Active sitei84NucleophileBy similarity1
Metal bindingi84Calcium; via 3-oxoalanineBy similarity1
Binding sitei137SubstrateBy similarity1
Active sitei139By similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi302CalciumBy similarity1
Metal bindingi303CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-CFA-1660662. Glycosphingolipid metabolism.
R-CFA-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase G (EC:3.1.6.-)
Short name:
ASG
Gene namesi
Name:ARSG
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000023866219 – 535Arylsulfatase GAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei843-oxoalanine (Cys)By similarity1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity
Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ32KH9.

Expressioni

Gene expression databases

BgeeiENSCAFG00000011070.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000016319.

Structurei

3D structure databases

ProteinModelPortaliQ32KH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ32KH9.
KOiK12381.
OMAiKAFYITG.
OrthoDBiEOG091G041Y.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiView protein in InterPro
IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core_sf.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
PfamiView protein in Pfam
PF00884. Sulfatase. 1 hit.
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiView protein in PROSITE
PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32KH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLFLKVLF LGVTFLGCLY PLVDFCPSGE TRGQKPNFVI ILADDMGWGD
60 70 80 90 100
LGANWAETKD TANLDKMAAE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN
110 120 130 140 150
GVTHNFAVTS VGGLPLNETT LAEVLQQAGY VTGMIGKWHL GHHGPYHPNF
160 170 180 190 200
RGFDYYFGIP YSHDMGCTDT PGYNHPPCPA CPRGDRPSRS LERDCYTDVA
210 220 230 240 250
LPLYENLNIV EQPVNLSSLA HKYAEKAIQF IQHASASGRP FLLYMGLAHM
260 270 280 290 300
HVPISRTQLS AVLRGRRPYG AGLREMDSLV GQIKDKVDRT AKENTFLWFT
310 320 330 340 350
GDNGPWAQKC ELAGSVGPFT GLWQTHQGGS PAKQTTWEGG HRVPALAYWP
360 370 380 390 400
GRVPVNVTST ALLSVLDIFP TVVALAGASL PQDRHFDGLD ASEVLFGWSQ
410 420 430 440 450
TGHRVLFHPN SGAAGEFGAL QTVRLGSYKA FYVSGGAKAC DGDVGREQHH
460 470 480 490 500
DPPLIFNLED DVAEAVPLDR GSAEYQGVLP KVREILADVL LDIAGDNTSR
510 520 530
ADYTRHPSVT PCCNPHHVAC RCQATGWTDF PTGRC
Length:535
Mass (Da):58,250
Last modified:December 6, 2005 - v1
Checksum:iD71E87A22A83575B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX02034846 Genomic DNA. No translation available.
BN000758 mRNA. Translation: CAI85004.1.
RefSeqiNP_001041563.1. NM_001048098.1.
UniGeneiCfa.37363.

Genome annotation databases

EnsembliENSCAFT00000017623; ENSCAFP00000016319; ENSCAFG00000011070.
GeneIDi480460.
KEGGicfa:480460.

Similar proteinsi

Entry informationi

Entry nameiARSG_CANLF
AccessioniPrimary (citable) accession number: Q32KH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 6, 2005
Last modified: January 31, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families