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Protein

Arylsulfatase H

Gene

ARSH

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15CalciumBy similarity1
Metal bindingi16CalciumBy similarity1
Active sitei55NucleophileBy similarity1
Metal bindingi55Calcium; via 3-oxoalanineBy similarity1
Binding sitei115SubstrateBy similarity1
Active sitei117By similarity1
Binding sitei271SubstrateBy similarity1
Metal bindingi323CalciumBy similarity1
Metal bindingi324CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase H (EC:3.1.6.-)
Short name:
ASH
Gene namesi
Name:ARSH
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956221 – 562Arylsulfatase HAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei553-oxoalanine (Cys)By similarity1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Proteomic databases

PaxDbiQ32KH8.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000016435.

Structurei

3D structure databases

ProteinModelPortaliQ32KH8.
SMRiQ32KH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ32KH8.
KOiK12374.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiView protein in InterPro
IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core_sf.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
PfamiView protein in Pfam
PF00884. Sulfatase. 1 hit.
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiView protein in PROSITE
PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32KH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRNSRPNIV LLMADDLGVG DLCCYGNNTV STPNIDRLAS EGVRLTQHLA
60 70 80 90 100
AASVCTPSRA AFLTGRYPIR SGMASPYNLN RGLTWLGGSG GLPTNETTFA
110 120 130 140 150
KLLQHYGYRT GLIGKWHQGL SCASRNDHCY HPLNHGFDYF YGLPFGLLSD
160 170 180 190 200
CQASRTPELH RWLRIKLWIS TAVLSLVPLL LLIPKYARWF VVPWKVILTF
210 220 230 240 250
ALLAFLFFIS WYSSYGFTRR WNCILMRNHE IIQQPMREER VASLMLKEAL
260 270 280 290 300
AFIDRYKRGP FLLFVSFLHV HTPLITKDKF VGHSKYGLYG DNVEEMDWMV
310 320 330 340 350
GKILETLDQE RLTNHTLVYF TSDNGGRLEV QEGEVQLGGS NGIYKGGQGM
360 370 380 390 400
GGWEGGIRVP GIFRWPTVLQ AGKVINEPTS LMDIYPTLSY IGGGMLPQDR
410 420 430 440 450
VIDGRNLMPL LEGRVSHSDH EFLFHYCGVY LHTARWHQKD CATVWKAHYV
460 470 480 490 500
TPKFSPDGAG ACYGSGICPC SGDVTYHDPP LLFDVSRDPS ETRPLNPDNE
510 520 530 540 550
ALFDSVVKKI EAAIKEHRRT LTPVPQQFSV FNTLWKPWLQ PCCGTFPFCG
560
CDKEDDILST AW
Length:562
Mass (Da):63,402
Last modified:December 6, 2005 - v1
Checksum:iE3D77B7C709C2E82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX01047377 Genomic DNA. No translation available.
BN000759 mRNA. Translation: CAI85005.1.
RefSeqiNP_001041588.1. NM_001048123.1.
UniGeneiCfa.39079.

Genome annotation databases

GeneIDi491720.
KEGGicfa:491720.

Similar proteinsi

Entry informationi

Entry nameiARSH_CANLF
AccessioniPrimary (citable) accession number: Q32KH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 6, 2005
Last modified: January 31, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families