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Protein
Submitted name:

Argonaute-1, isoform A

Gene

AGO1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: FlyBase
  • miRNA binding Source: FlyBase

GO - Biological processi

  • chromatin silencing Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • gene silencing by miRNA Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • germarium-derived oocyte fate determination Source: FlyBase
  • habituation Source: FlyBase
  • mRNA catabolic process Source: FlyBase
  • mRNA cleavage involved in gene silencing by miRNA Source: FlyBase
  • negative regulation of translation Source: FlyBase
  • production of miRNAs involved in gene silencing by miRNA Source: FlyBase
  • production of siRNA involved in RNA interference Source: FlyBase
  • regulation of olfactory learning Source: FlyBase
  • RNA interference Source: FlyBase
  • segment polarity determination Source: FlyBase
  • synapse assembly Source: FlyBase
  • targeting of mRNA for destruction involved in RNA interference Source: FlyBase

Keywordsi

Biological processRNA-mediated gene silencingSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-203927 MicroRNA (miRNA) biogenesis
R-DME-426486 Small interfering RNA (siRNA) biogenesis
R-DME-426496 Post-transcriptional silencing by small RNAs
R-DME-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Submitted name:
Argonaute-1, isoform AImported
Submitted name:
Argonaute-1, isoform CImported
Submitted name:
Argonaute-1, isoform DImported
Submitted name:
LP02696pImported
Submitted name:
SD07283pImported
Gene namesi
Name:AGO1Imported
Synonyms:AGO1-RCImported
ORF Names:CG6671Imported, Dmel_CG6671Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0262739 AGO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ32KD4

Expressioni

Gene expression databases

BgeeiFBgn0262739
ExpressionAtlasiQ32KD4 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gwQ8SY334EBI-105513,EBI-160693

GO - Molecular functioni

  • enzyme binding Source: FlyBase

Protein-protein interaction databases

DIPiDIP-59685N
IntActiQ32KD4, 6 interactors
STRINGi7227.FBpp0294043

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R4KNMR-A331-498[»]
SMRiQ32KD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini337 – 457PAZInterPro annotationAdd BLAST121
Domaini641 – 943PiwiInterPro annotationAdd BLAST303

Sequence similaritiesi

Belongs to the argonaute family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1041 Eukaryota
ENOG410XP07 LUCA
GeneTreeiENSGT00760000119148
KOiK11593
OrthoDBiEOG091G020J

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR014811 ArgoL1
IPR032472 ArgoL2
IPR032473 Argonaute_Mid_dom
IPR032474 Argonaute_N
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR003165 Piwi
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF08699 ArgoL1, 1 hit
PF16488 ArgoL2, 1 hit
PF16487 ArgoMid, 1 hit
PF16486 ArgoN, 1 hit
PF02170 PAZ, 1 hit
PF02171 Piwi, 1 hit
SMARTiView protein in SMART
SM01163 DUF1785, 1 hit
SM00949 PAZ, 1 hit
SM00950 Piwi, 1 hit
SUPFAMiSSF101690 SSF101690, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821 PAZ, 1 hit
PS50822 PIWI, 1 hit

Sequencei

Sequence statusi: Complete.

Q32KD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTERELAPG GPAQLHPHTL PLTFPDLQMT STVGIIGKVY ESQWTPSPTR
60 70 80 90 100
PQSPSQAQTS FDTLTSPPAP GSSVNPTAVT SPSAQNVAAG GATVAGAAAT
110 120 130 140 150
AAQVASALGA TTGSVTPAIA TATPATQPDM PVFTCPRRPN LGREGRPIVL
160 170 180 190 200
RANHFQVTMP RGYVHHYDIN IQPDKCPRKV NREIIETMVH AYSKIFGVLK
210 220 230 240 250
PVFDGRNNLY TRDPLPIGNE RLELEVTLPG EGKDRIFRVT IKWQAQVSLF
260 270 280 290 300
NLEEALEGRT RQIPYDAILA LDVVMRHLPS MTYTPVGRSF FSSPEGYYHP
310 320 330 340 350
LGGGREVWFG FHQSVRPSQW KMMLNIDVSA TAFYKAQPVI DFMCEVLDIR
360 370 380 390 400
DINEQRKPLT DSQRVKFTKE IKGLKIEITH CGQMRRKYRV CNVTRRPAQM
410 420 430 440 450
QSFPLQLENG QTVECTVAKY FLDKYRMKLR YPHLPCLQVG QEHKHTYLPL
460 470 480 490 500
EVCNIVAGQR CIKKLTDMQT STMIKATARS APDREREINN LVKRADFNND
510 520 530 540 550
SYVQEFGLTI SNSMMEVRGR VLPPPKLQYG GRVSTGLTGQ QLFPPQNKVS
560 570 580 590 600
LASPNQGVWD MRGKQFFTGV EIRIWAIACF APQRTVREDA LRNFTQQLQK
610 620 630 640 650
ISNDAGMPII GQPCFCKYAT GPDQVEPMFR YLKITFPGLQ LVVVVLPGKT
660 670 680 690 700
PVYAEVKRVG DTVLGMATQC VQAKNVNKTS PQTLSNLCLK INVKLGGINS
710 720 730 740 750
ILVPSIRPKV FNEPVIFLGA DVTHPPAGDN KKPSIAAVVG SMDAHPSRYA
760 770 780 790 800
ATVRVQQHRQ EIIQELSSMV RELLIMFYKS TGGYKPHRII LYRDGVSEGQ
810 820 830 840 850
FPHVLQHELT AIREACIKLE PEYRPGITFI VVQKRHHTRL FCAEKKEQSG
860 870 880 890 900
KSGNIPAGTT VDVGITHPTE FDFYLCSHQG IQGTSRPSHY HVLWDDNHFD
910 920 930 940 950
SDELQCLTYQ LCHTYVRCTR SVSIPAPAYY AHLVAFRARY HLVEKEHDSG
960 970 980
EGSHQSGCSE DRTPGAMARA ITVHADTKKV MYFA
Length:984
Mass (Da):109,830
Last modified:October 3, 2006 - v1
Checksum:i123C95C10ACD442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58313.1
AE013599 Genomic DNA Translation: AAF58314.1
BT023945 mRNA Translation: ABB36449.1
BT125895 mRNA Translation: ADV19036.1
AE013599 Genomic DNA Translation: AFH08068.1
RefSeqiNP_001246314.1, NM_001259385.1
NP_725341.1, NM_166020.2
NP_725342.1, NM_166021.2
UniGeneiDm.7398

Genome annotation databases

EnsemblMetazoaiFBtr0087612; FBpp0086738; FBgn0262739
FBtr0087613; FBpp0086739; FBgn0262739
FBtr0305592; FBpp0294043; FBgn0262739
GeneIDi36544
KEGGidme:Dmel_CG6671
UCSCiCG6671-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ32KD4_DROME
AccessioniPrimary (citable) accession number: Q32KD4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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