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Protein
Submitted name:

Argonaute-1, isoform A

Gene

AGO1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: FlyBase
  • miRNA binding Source: FlyBase

GO - Biological processi

  • chromatin silencing Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • gene silencing by miRNA Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • germarium-derived oocyte fate determination Source: FlyBase
  • habituation Source: FlyBase
  • mRNA catabolic process Source: FlyBase
  • mRNA cleavage involved in gene silencing by miRNA Source: FlyBase
  • negative regulation of translation Source: FlyBase
  • production of miRNAs involved in gene silencing by miRNA Source: FlyBase
  • production of siRNA involved in RNA interference Source: FlyBase
  • regulation of olfactory learning Source: FlyBase
  • RNA interference Source: FlyBase
  • segment polarity determination Source: FlyBase
  • synapse assembly Source: FlyBase
  • targeting of mRNA for destruction involved in RNA interference Source: FlyBase

Keywordsi

Biological processRNA-mediated gene silencingSAAS annotation

Enzyme and pathway databases

ReactomeiR-DME-203927. MicroRNA (miRNA) biogenesis.
R-DME-426486. Small interfering RNA (siRNA) biogenesis.
R-DME-426496. Post-transcriptional silencing by small RNAs.
R-DME-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Submitted name:
Argonaute-1, isoform AImported
Submitted name:
Argonaute-1, isoform CImported
Submitted name:
Argonaute-1, isoform DImported
Submitted name:
LP02696pImported
Submitted name:
SD07283pImported
Gene namesi
Name:AGO1Imported
Synonyms:AGO1-RCImported, CG6671Imported
ORF Names:Dmel_CG6671Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0262739. AGO1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0262739.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: FlyBase

Protein-protein interaction databases

DIPiDIP-59685N.
IntActiQ32KD4. 6 interactors.
STRINGi7227.FBpp0294043.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R4KNMR-A331-498[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini337 – 457PAZInterPro annotationAdd BLAST121
Domaini641 – 943PiwiInterPro annotationAdd BLAST303

Sequence similaritiesi

Belongs to the argonaute family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
GeneTreeiENSGT00760000119148.
KOiK11593.
OMAiSPDGYYH.
OrthoDBiEOG091G020J.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiView protein in InterPro
IPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR036085. PAZ_dom_sf.
IPR003165. Piwi.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PfamiView protein in Pfam
PF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
SMARTiView protein in SMART
SM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32KD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTERELAPG GPAQLHPHTL PLTFPDLQMT STVGIIGKVY ESQWTPSPTR
60 70 80 90 100
PQSPSQAQTS FDTLTSPPAP GSSVNPTAVT SPSAQNVAAG GATVAGAAAT
110 120 130 140 150
AAQVASALGA TTGSVTPAIA TATPATQPDM PVFTCPRRPN LGREGRPIVL
160 170 180 190 200
RANHFQVTMP RGYVHHYDIN IQPDKCPRKV NREIIETMVH AYSKIFGVLK
210 220 230 240 250
PVFDGRNNLY TRDPLPIGNE RLELEVTLPG EGKDRIFRVT IKWQAQVSLF
260 270 280 290 300
NLEEALEGRT RQIPYDAILA LDVVMRHLPS MTYTPVGRSF FSSPEGYYHP
310 320 330 340 350
LGGGREVWFG FHQSVRPSQW KMMLNIDVSA TAFYKAQPVI DFMCEVLDIR
360 370 380 390 400
DINEQRKPLT DSQRVKFTKE IKGLKIEITH CGQMRRKYRV CNVTRRPAQM
410 420 430 440 450
QSFPLQLENG QTVECTVAKY FLDKYRMKLR YPHLPCLQVG QEHKHTYLPL
460 470 480 490 500
EVCNIVAGQR CIKKLTDMQT STMIKATARS APDREREINN LVKRADFNND
510 520 530 540 550
SYVQEFGLTI SNSMMEVRGR VLPPPKLQYG GRVSTGLTGQ QLFPPQNKVS
560 570 580 590 600
LASPNQGVWD MRGKQFFTGV EIRIWAIACF APQRTVREDA LRNFTQQLQK
610 620 630 640 650
ISNDAGMPII GQPCFCKYAT GPDQVEPMFR YLKITFPGLQ LVVVVLPGKT
660 670 680 690 700
PVYAEVKRVG DTVLGMATQC VQAKNVNKTS PQTLSNLCLK INVKLGGINS
710 720 730 740 750
ILVPSIRPKV FNEPVIFLGA DVTHPPAGDN KKPSIAAVVG SMDAHPSRYA
760 770 780 790 800
ATVRVQQHRQ EIIQELSSMV RELLIMFYKS TGGYKPHRII LYRDGVSEGQ
810 820 830 840 850
FPHVLQHELT AIREACIKLE PEYRPGITFI VVQKRHHTRL FCAEKKEQSG
860 870 880 890 900
KSGNIPAGTT VDVGITHPTE FDFYLCSHQG IQGTSRPSHY HVLWDDNHFD
910 920 930 940 950
SDELQCLTYQ LCHTYVRCTR SVSIPAPAYY AHLVAFRARY HLVEKEHDSG
960 970 980
EGSHQSGCSE DRTPGAMARA ITVHADTKKV MYFA
Length:984
Mass (Da):109,830
Last modified:October 3, 2006 - v1
Checksum:i123C95C10ACD442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58313.1.
AE013599 Genomic DNA. Translation: AAF58314.1.
BT023945 mRNA. Translation: ABB36449.1.
BT125895 mRNA. Translation: ADV19036.1.
AE013599 Genomic DNA. Translation: AFH08068.1.
RefSeqiNP_001246314.1. NM_001259385.1.
NP_725341.1. NM_166020.2.
NP_725342.1. NM_166021.2.
UniGeneiDm.7398.

Genome annotation databases

EnsemblMetazoaiFBtr0087612; FBpp0086738; FBgn0262739.
FBtr0087613; FBpp0086739; FBgn0262739.
FBtr0305592; FBpp0294043; FBgn0262739.
GeneIDi36544.
KEGGidme:Dmel_CG6671.
UCSCiCG6671-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ32KD4_DROME
AccessioniPrimary (citable) accession number: Q32KD4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 25, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported