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Protein
Submitted name:

Argonaute-1, isoform A

Gene

AGO1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: FlyBase
  • miRNA binding Source: FlyBase

GO - Biological processi

  • chromatin silencing Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • gene silencing by miRNA Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • germarium-derived oocyte fate determination Source: FlyBase
  • habituation Source: FlyBase
  • mRNA catabolic process Source: FlyBase
  • mRNA cleavage involved in gene silencing by miRNA Source: FlyBase
  • negative regulation of translation Source: FlyBase
  • production of miRNAs involved in gene silencing by miRNA Source: FlyBase
  • production of siRNA involved in RNA interference Source: FlyBase
  • regulation of olfactory learning Source: FlyBase
  • RNA interference Source: FlyBase
  • segment polarity determination Source: FlyBase
  • synapse assembly Source: FlyBase
  • targeting of mRNA for destruction involved in RNA interference Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-203927. MicroRNA (miRNA) biogenesis.
R-DME-426486. Small interfering RNA (siRNA) biogenesis.
R-DME-426496. Post-transcriptional silencing by small RNAs.
R-DME-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Submitted name:
Argonaute-1, isoform AImported
Submitted name:
Argonaute-1, isoform CImported
Submitted name:
Argonaute-1, isoform DImported
Submitted name:
LP02696pImported
Submitted name:
SD07283pImported
Gene namesi
Name:AGO1Imported
Synonyms:AGO1-RCImported
ORF Names:CG6671Imported, Dmel_CG6671Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0262739. AGO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • intracellular ribonucleoprotein complex Source: FlyBase
  • nucleus Source: FlyBase
  • perinuclear region of cytoplasm Source: FlyBase
Complete GO annotation...

Interactioni

GO - Molecular functioni

  • enzyme binding Source: FlyBase

Protein-protein interaction databases

DIPiDIP-59685N.
STRINGi7227.FBpp0294043.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R4KNMR-A331-498[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini337 – 457121PAZInterPro annotationAdd
BLAST
Domaini641 – 943303PiwiInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the argonaute family.UniRule annotation
Contains 1 PAZ domain.UniRule annotation
Contains 1 Piwi domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
GeneTreeiENSGT00760000119148.
KOiK11593.
OMAiITGQQLF.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32KD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTERELAPG GPAQLHPHTL PLTFPDLQMT STVGIIGKVY ESQWTPSPTR
60 70 80 90 100
PQSPSQAQTS FDTLTSPPAP GSSVNPTAVT SPSAQNVAAG GATVAGAAAT
110 120 130 140 150
AAQVASALGA TTGSVTPAIA TATPATQPDM PVFTCPRRPN LGREGRPIVL
160 170 180 190 200
RANHFQVTMP RGYVHHYDIN IQPDKCPRKV NREIIETMVH AYSKIFGVLK
210 220 230 240 250
PVFDGRNNLY TRDPLPIGNE RLELEVTLPG EGKDRIFRVT IKWQAQVSLF
260 270 280 290 300
NLEEALEGRT RQIPYDAILA LDVVMRHLPS MTYTPVGRSF FSSPEGYYHP
310 320 330 340 350
LGGGREVWFG FHQSVRPSQW KMMLNIDVSA TAFYKAQPVI DFMCEVLDIR
360 370 380 390 400
DINEQRKPLT DSQRVKFTKE IKGLKIEITH CGQMRRKYRV CNVTRRPAQM
410 420 430 440 450
QSFPLQLENG QTVECTVAKY FLDKYRMKLR YPHLPCLQVG QEHKHTYLPL
460 470 480 490 500
EVCNIVAGQR CIKKLTDMQT STMIKATARS APDREREINN LVKRADFNND
510 520 530 540 550
SYVQEFGLTI SNSMMEVRGR VLPPPKLQYG GRVSTGLTGQ QLFPPQNKVS
560 570 580 590 600
LASPNQGVWD MRGKQFFTGV EIRIWAIACF APQRTVREDA LRNFTQQLQK
610 620 630 640 650
ISNDAGMPII GQPCFCKYAT GPDQVEPMFR YLKITFPGLQ LVVVVLPGKT
660 670 680 690 700
PVYAEVKRVG DTVLGMATQC VQAKNVNKTS PQTLSNLCLK INVKLGGINS
710 720 730 740 750
ILVPSIRPKV FNEPVIFLGA DVTHPPAGDN KKPSIAAVVG SMDAHPSRYA
760 770 780 790 800
ATVRVQQHRQ EIIQELSSMV RELLIMFYKS TGGYKPHRII LYRDGVSEGQ
810 820 830 840 850
FPHVLQHELT AIREACIKLE PEYRPGITFI VVQKRHHTRL FCAEKKEQSG
860 870 880 890 900
KSGNIPAGTT VDVGITHPTE FDFYLCSHQG IQGTSRPSHY HVLWDDNHFD
910 920 930 940 950
SDELQCLTYQ LCHTYVRCTR SVSIPAPAYY AHLVAFRARY HLVEKEHDSG
960 970 980
EGSHQSGCSE DRTPGAMARA ITVHADTKKV MYFA
Length:984
Mass (Da):109,830
Last modified:October 3, 2006 - v1
Checksum:i123C95C10ACD442E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58313.1.
AE013599 Genomic DNA. Translation: AAF58314.1.
BT023945 mRNA. Translation: ABB36449.1.
BT125895 mRNA. Translation: ADV19036.1.
AE013599 Genomic DNA. Translation: AFH08068.1.
RefSeqiNP_001246314.1. NM_001259385.1.
NP_725341.1. NM_166020.2.
NP_725342.1. NM_166021.2.
UniGeneiDm.7398.

Genome annotation databases

EnsemblMetazoaiFBtr0087612; FBpp0086738; FBgn0262739.
FBtr0087613; FBpp0086739; FBgn0262739.
FBtr0305592; FBpp0294043; FBgn0262739.
GeneIDi36544.
KEGGidme:Dmel_CG6671.
UCSCiCG6671-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58313.1.
AE013599 Genomic DNA. Translation: AAF58314.1.
BT023945 mRNA. Translation: ABB36449.1.
BT125895 mRNA. Translation: ADV19036.1.
AE013599 Genomic DNA. Translation: AFH08068.1.
RefSeqiNP_001246314.1. NM_001259385.1.
NP_725341.1. NM_166020.2.
NP_725342.1. NM_166021.2.
UniGeneiDm.7398.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R4KNMR-A331-498[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59685N.
STRINGi7227.FBpp0294043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087612; FBpp0086738; FBgn0262739.
FBtr0087613; FBpp0086739; FBgn0262739.
FBtr0305592; FBpp0294043; FBgn0262739.
GeneIDi36544.
KEGGidme:Dmel_CG6671.
UCSCiCG6671-RA. d. melanogaster.

Organism-specific databases

CTDi26523.
FlyBaseiFBgn0262739. AGO1.

Phylogenomic databases

eggNOGiKOG1041. Eukaryota.
ENOG410XP07. LUCA.
GeneTreeiENSGT00760000119148.
KOiK11593.
OMAiITGQQLF.

Enzyme and pathway databases

ReactomeiR-DME-203927. MicroRNA (miRNA) biogenesis.
R-DME-426486. Small interfering RNA (siRNA) biogenesis.
R-DME-426496. Post-transcriptional silencing by small RNAs.
R-DME-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

GenomeRNAii36544.
NextBioi799120.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR014811. ArgoL1.
IPR032472. ArgoL2.
IPR032473. Argonaute_Mid_dom.
IPR032474. Argonaute_N.
IPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF08699. ArgoL1. 1 hit.
PF16488. ArgoL2. 1 hit.
PF16487. ArgoMid. 1 hit.
PF16486. ArgoN. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM01163. DUF1785. 1 hit.
SM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Structure and conserved RNA binding of the PAZ domain."
    Yan K.S., Yan S., Farooq A., Han A., Zeng L., Zhou M.M.
    Nature 426:468-474(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 331-498.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ32KD4_DROME
AccessioniPrimary (citable) accession number: Q32KD4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.