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Protein

L-carnitine CoA-transferase

Gene

caiB

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.UniRule annotation

Catalytic activityi

(E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA.UniRule annotation
4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97Coenzyme AUniRule annotation1
Binding sitei104Coenzyme AUniRule annotation1
Active sitei169NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
L-carnitine CoA-transferaseUniRule annotation (EC:2.8.3.21UniRule annotation)
Alternative name(s):
Crotonobetainyl-CoA:carnitine CoA-transferaseUniRule annotation
Gene namesi
Name:caiBUniRule annotation
Ordered Locus Names:SDY_0060
OrganismiShigella dysenteriae serotype 1 (strain Sd197)
Taxonomic identifieri300267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002716 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003009831 – 405L-carnitine CoA-transferaseAdd BLAST405

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ32K59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CaiB/BaiF CoA-transferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219745.
KOiK08298.
OMAiVMPKFKN.
OrthoDBiPOG091H08U4.

Family and domain databases

Gene3Di3.40.50.10540. 2 hits.
HAMAPiMF_01050. CaiB. 1 hit.
InterProiIPR023452. CoA-Trfase_CaiB.
IPR003673. CoA-Trfase_fam_III.
IPR023606. CoA-Trfase_III_dom.
[Graphical view]
PfamiPF02515. CoA_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF89796. SSF89796. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32K59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHLPMPKFG PLAGLRVVFS GIEIAGPFAG QMFAEWGAEV IWIENVAWAD
60 70 80 90 100
TIRVQPNYPQ LSRRNLHALS LNIFKDEGRE AFLKLMETTD IFIEASKGPA
110 120 130 140 150
FARRGITDEV LWQHNPKLVI AHLSGFGQYG TEEYTNLPAY NTIAQAFSGY
160 170 180 190 200
LIQNGDVDQP MPAFPYTADY FSGLTATTAA LAALHKARET GKGESIDIAM
210 220 230 240 250
YEVMLRMGQY FMMDYFNGGE MCPRMSKGKD PYYAGCGLYK CADGYIVMEL
260 270 280 290 300
VGITQIEECF KDIGLAHLLG TPEIPEGTQL IHRIECPYGP LVEEKLDAWL
310 320 330 340 350
AAHTIAEVKE RFAELNIACA KVLTVPELES NPQYVARESI TQWQTMDGRT
360 370 380 390 400
CKRPNIMPKF KNNPGQIWRG MPSHGMDTAA ILKNIGYSEN DIQELVSKGL

AKVED
Length:405
Mass (Da):45,168
Last modified:December 6, 2005 - v1
Checksum:iEE83CEED4EECD2A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB60298.1.
RefSeqiWP_000349923.1. NC_007606.1.
YP_401787.1. NC_007606.1.

Genome annotation databases

EnsemblBacteriaiABB60298; ABB60298; SDY_0060.
GeneIDi3798940.
KEGGisdy:SDY_0060.
PATRICi18689128. VBIShiDys99784_0066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB60298.1.
RefSeqiWP_000349923.1. NC_007606.1.
YP_401787.1. NC_007606.1.

3D structure databases

ProteinModelPortaliQ32K59.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB60298; ABB60298; SDY_0060.
GeneIDi3798940.
KEGGisdy:SDY_0060.
PATRICi18689128. VBIShiDys99784_0066.

Phylogenomic databases

HOGENOMiHOG000219745.
KOiK08298.
OMAiVMPKFKN.
OrthoDBiPOG091H08U4.

Enzyme and pathway databases

UniPathwayiUPA00117.

Family and domain databases

Gene3Di3.40.50.10540. 2 hits.
HAMAPiMF_01050. CaiB. 1 hit.
InterProiIPR023452. CoA-Trfase_CaiB.
IPR003673. CoA-Trfase_fam_III.
IPR023606. CoA-Trfase_III_dom.
[Graphical view]
PfamiPF02515. CoA_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF89796. SSF89796. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAIB_SHIDS
AccessioniPrimary (citable) accession number: Q32K59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.