Q32EZ9 (6PGL_SHIDS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6-P-gluconolactonase
EC=3.1.1.31

Gene names

Name:	pgl
Ordered Locus Names:	SDY_2011

Organism

Shigella dysenteriae serotype 1 (strain Sd197) [Reference proteome] [HAMAP]

Taxonomic identifier

300267 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella › Shigella dysenteriae

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP-Rule MF_01605
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP-Rule MF_01605
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP-Rule MF_01605
Sequence similarities	Belongs to the cycloisomerase 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	6-phosphogluconolactonase HAMAP-Rule MF_01605		PRO_0000291470
Amino acid modifications
	Modified residue	287	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q32EZ9 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: D731044CFCF31A8F	FASTA	331	36,308
	10 20 30 40 50 60 MKQTVYIASP ESQQIHVWNL NHEGALTLTQ VVDVPGQVQP MVVSPDKRYL YVGVRPEFRV 70 80 90 100 110 120 LAYRIAPDDG ALTFAAESAL PGSPTHISTD HQGQFVFVGS YNAGNVSVTR LEDGLPVGVV 130 140 150 160 170 180 DVVEGLDGCH SANISPDNRT LWVPALKQDR ICLFTVSDDG HLVAQDPAEV TTVEGAGPRH 190 200 210 220 230 240 MVFHPNEQYA YCVNELNSSV DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG 250 260 270 280 290 300 RHLYACDRTA SLITVFSVSE DGSVLSKEGF QPTETQPRGF NVDHSGKYLI AAGQKSHHIS 310 320 330 VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H

References

[1]

"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. , Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. Nucleic Acids Res. 33:6445-6458(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sd197.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000034 Genomic DNA. Translation: ABB62106.1.
RefSeq	YP_403597.1. NC_007606.1.
3D structure databases
ProteinModelPortal	Q32EZ9.
SMR	Q32EZ9. Positions 1-331.
ModBase	Search...
Protein-protein interaction databases
STRING	300267.SDY_2011.
Proteomic databases
PRIDE	Q32EZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB62106; ABB62106; SDY_2011.
GeneID	3799907.
KEGG	sdy:SDY_2011.
PATRIC	18693983. VBIShiDys99784_2424.
Phylogenomic databases
eggNOG	COG2706.
HOGENOM	HOG000257418.
KO	K07404.
OMA	IDHSGKY.
ProtClustDB	PRK11028.
Enzyme and pathway databases
BioCyc	SDYS300267:GJEW-2007-MONOMER.
UniPathway	UPA00115; UER00409.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
HAMAP	MF_01605. 6P-gluconolactonase.
InterPro	IPR022528. 6-phosphogluconolactonase_YbhE. IPR019405. Lactonase_7-beta_prop. IPR011045. N2O_reductase_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Pfam	PF10282. Lactonase. 1 hit. [Graphical view]
SUPFAM	SSF50974. N2O_reductase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_SHIDS

Accession

Primary (citable) accession number: Q32EZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program