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Protein

Putative pyrimidine-specific ribonucleoside hydrolase RihB

Gene

rihB

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A pyrimidine nucleoside + H2O = D-ribose + a pyrimidine base.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei185 – 1851SubstrateBy similarity
Binding sitei197 – 1971SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSDYS300267:GJEW-2100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyrimidine-specific ribonucleoside hydrolase RihB (EC:3.2.2.8)
Alternative name(s):
Cytidine/uridine-specific hydrolase
Gene namesi
Name:rihB
Ordered Locus Names:SDY_2104
OrganismiShigella dysenteriae serotype 1 (strain Sd197)
Taxonomic identifieri300267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002716 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Putative pyrimidine-specific ribonucleoside hydrolase RihBPRO_0000206828Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ32ER0.
SMRiQ32ER0. Positions 6-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IUNH family. RihB subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000218839.
KOiK10213.
OMAiLFPLDCT.
OrthoDBiPOG091H03IC.

Family and domain databases

Gene3Di3.90.245.10. 1 hit.
InterProiIPR023186. Inosine/uridine_hydrolase.
IPR001910. Inosine/uridine_hydrolase_dom.
[Graphical view]
PANTHERiPTHR12304. PTHR12304. 1 hit.
PfamiPF01156. IU_nuc_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53590. SSF53590. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32ER0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALPINGLN VCQKLEINVP VYAGMPQPIM RQQIVADNIH GETGLDGPVF
60 70 80 90 100
EPLTRQAEST HAVKYIIDTL MASDGDITLV PVGPLSNIAV AMRMQPAILP
110 120 130 140 150
KIREIVLMGG AYGTGNFTPS AEFNIFADPE AARVVFTSGV PLVMMGLDLT
160 170 180 190 200
NQTVCTPDVI ARMERAGGPA GELFSDIMNF TLKTQFENYG LAGGPVHDAT
210 220 230 240 250
CIGYLINPDG IKTQDMYVEV DVNSGPCYGR TVCDELGVLG KPANTKVGIT
260 270
IDTDWFWGLV EECVRGYIKT H
Length:271
Mass (Da):29,164
Last modified:December 6, 2005 - v1
Checksum:i044B86FD8E8074DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB62195.1.
RefSeqiWP_000729486.1. NC_007606.1.
YP_403686.1. NC_007606.1.

Genome annotation databases

EnsemblBacteriaiABB62195; ABB62195; SDY_2104.
GeneIDi3798860.
KEGGisdy:SDY_2104.
PATRICi18694204. VBIShiDys99784_2534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB62195.1.
RefSeqiWP_000729486.1. NC_007606.1.
YP_403686.1. NC_007606.1.

3D structure databases

ProteinModelPortaliQ32ER0.
SMRiQ32ER0. Positions 6-269.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB62195; ABB62195; SDY_2104.
GeneIDi3798860.
KEGGisdy:SDY_2104.
PATRICi18694204. VBIShiDys99784_2534.

Phylogenomic databases

HOGENOMiHOG000218839.
KOiK10213.
OMAiLFPLDCT.
OrthoDBiPOG091H03IC.

Enzyme and pathway databases

BioCyciSDYS300267:GJEW-2100-MONOMER.

Family and domain databases

Gene3Di3.90.245.10. 1 hit.
InterProiIPR023186. Inosine/uridine_hydrolase.
IPR001910. Inosine/uridine_hydrolase_dom.
[Graphical view]
PANTHERiPTHR12304. PTHR12304. 1 hit.
PfamiPF01156. IU_nuc_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53590. SSF53590. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIHB_SHIDS
AccessioniPrimary (citable) accession number: Q32ER0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This sequence is 42 amino acid shorter than orthologs and therefore lacks two conserved residues involved in calcium binding and active site activity. The two other residues involved in calcium binding are present but it is not known if they still bind calcium.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.