Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hydroxylamine reductase

Gene

hcp

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of hydroxylamine to form NH3 and H2O.UniRule annotation

Catalytic activityi

NH3 + H2O + acceptor = hydroxylamine + reduced acceptor.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • hybrid [4Fe-2O-2S] clusterUniRule annotationNote: Binds 1 hybrid [4Fe-2O-2S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi8Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi20Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi27Iron-sulfur (2Fe-2S)UniRule annotation1
Metal bindingi251Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogenUniRule annotation1
Metal bindingi275Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi319Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi407Iron-oxo-sulfur (4Fe-2O-2S); via persulfide groupUniRule annotation1
Metal bindingi435Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi460Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi494Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1
Metal bindingi496Iron-oxo-sulfur (4Fe-2O-2S)UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxylamine reductaseUniRule annotation (EC:1.7.99.1UniRule annotation)
Alternative name(s):
Hybrid-cluster proteinUniRule annotation
Short name:
HCPUniRule annotation
Prismane proteinUniRule annotation
Gene namesi
Name:hcpUniRule annotation
Ordered Locus Names:SDY_2390
OrganismiShigella dysenteriae serotype 1 (strain Sd197)
Taxonomic identifieri300267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002716 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000091731 – 552Hydroxylamine reductaseAdd BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407Cysteine persulfideUniRule annotation1

Family & Domainsi

Sequence similaritiesi

Belongs to the HCP family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000007176.
OMAiCAYAQGM.
OrthoDBiPOG091H0NWT.

Family and domain databases

CDDicd01914. HCP. 1 hit.
Gene3Di1.20.1270.20. 2 hits.
3.40.50.2030. 2 hits.
HAMAPiMF_00069. Hydroxylam_reduct. 1 hit.
InterProiIPR004137. HCP/CODH.
IPR010048. Hydroxylam_reduct.
IPR011254. Prismane-like.
IPR016099. Prismane-like_a/b-sand.
IPR016100. Prismane_a-bundle.
[Graphical view]
PANTHERiPTHR30109:SF0. PTHR30109:SF0. 1 hit.
PfamiPF03063. Prismane. 1 hit.
[Graphical view]
PIRSFiPIRSF000076. HCP. 1 hit.
SUPFAMiSSF56821. SSF56821. 1 hit.
TIGRFAMsiTIGR01703. hybrid_clust. 1 hit.

Sequencei

Sequence statusi: Complete.

Q32DZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMFCVQCEQ TIRTPAGNGC SYAQGMCGKT AETSDLQDLL IAALQGLSAW
60 70 80 90 100
AVKAREYGII NHDVDSFAPR AFFSTLTNVN FDSPRIVGYA REAIALREAL
110 120 130 140 150
KAQCLAVDAN ARVDNPMADL QLVSDDLGEL QRQAAEFTPN KDKAAIGENI
160 170 180 190 200
LGLRLLCLYG LKGAAAYMEH AHVLGQYDND IYAQYHKIMA WLGTWPADMN
210 220 230 240 250
ALLECSMEIG QMNFKVMSIL DAGETGKYGH PTPTQVNVKA TAGKCILISG
260 270 280 290 300
HDLKDLYNLL EQTKGTGVNV YTHGEMLPAH GYPELRKFKH LVGNYGSGWQ
310 320 330 340 350
NQQVEFARFP GPIVMTSNCI IDPTVGAYDD RIWTRSIVGW PGVRHLDGED
360 370 380 390 400
FSAVIAQAQQ MAGFLYSEIP HLITVGFGRQ TLLGAADTLI DLVSREKLRH
410 420 430 440 450
IFLLGGCDGA RGERHYFTDF ATNVPDDCLI LTLACGKYRF NKLEFGDIEG
460 470 480 490 500
LPRLVDAGQC NDAYSAIILA VTLAEKLGCG VNDLPLSLVL SWFEQKAIVI
510 520 530 540 550
LLTLLSLGVK NIVTGPTAPG FLTPDLLAVL NEKFGLRSIT TVEEDMKQLL

SA
Length:552
Mass (Da):60,334
Last modified:December 6, 2005 - v1
Checksum:i308D3ED236A0809E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB62464.1.

Genome annotation databases

EnsemblBacteriaiABB62464; ABB62464; SDY_2390.
PATRICi18694916. VBIShiDys99784_2883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB62464.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB62464; ABB62464; SDY_2390.
PATRICi18694916. VBIShiDys99784_2883.

Phylogenomic databases

HOGENOMiHOG000007176.
OMAiCAYAQGM.
OrthoDBiPOG091H0NWT.

Family and domain databases

CDDicd01914. HCP. 1 hit.
Gene3Di1.20.1270.20. 2 hits.
3.40.50.2030. 2 hits.
HAMAPiMF_00069. Hydroxylam_reduct. 1 hit.
InterProiIPR004137. HCP/CODH.
IPR010048. Hydroxylam_reduct.
IPR011254. Prismane-like.
IPR016099. Prismane-like_a/b-sand.
IPR016100. Prismane_a-bundle.
[Graphical view]
PANTHERiPTHR30109:SF0. PTHR30109:SF0. 1 hit.
PfamiPF03063. Prismane. 1 hit.
[Graphical view]
PIRSFiPIRSF000076. HCP. 1 hit.
SUPFAMiSSF56821. SSF56821. 1 hit.
TIGRFAMsiTIGR01703. hybrid_clust. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHCP_SHIDS
AccessioniPrimary (citable) accession number: Q32DZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.