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Protein

Glutamate decarboxylase

Gene

gadA

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSDYS300267:GJEW-3528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadAImported
Ordered Locus Names:SDY_3532Imported
OrganismiShigella dysenteriae serotype 1 (strain Sd197)Imported
Taxonomic identifieri300267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002716 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PaxDbiQ32AZ6.

Interactioni

Protein-protein interaction databases

STRINGi300267.SDY_3532.

Structurei

3D structure databases

ProteinModelPortaliQ32AZ6.
SMRiQ32AZ6. Positions 44-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG618QPT.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32AZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRVLTMAV DLCRLTTRTM NVNAGHERTS KARIIHQIQL IRGITDELYL
60 70 80 90 100
DGNARQNLAT FCQTWDDENV HKFMDLSINK NWIDKEEYPQ SAAIDLRCVN
110 120 130 140 150
MVADLWHAPA PKNGQAVGTN TIGSSEACML GGMAMKWRWR KRMEAAGKPT
160 170 180 190 200
DKPNLVCGPV QICWHKFARY WDVELREIPM RPGQLFMDPK RMIEACDENT
210 220 230 240 250
IGVVPTFGVT YTGNYEFPQP LHDALDKFQA DTGIDIDMHI DAASGGFLAP
260 270 280 290 300
FVAPDIVWDF RLPRVKSISA SGHKFGLAPL GCGWVIWRDE EALPQELVFN
310 320 330 340 350
VDYLGGQIGT FAINFSRPAG QVIAQYYEFL RLGREGYTKV QNASYQVAAY
360 370 380 390 400
LADEIAKLGP YEFICTGRPD EGIPAVCFKL KDGEDPGYTL YNLSERLRLR
410 420 430 440 450
GWQVPAFTLG GEATDIVVMR IMCRRGFEMD FAELLLEDYK ASLKYLSDHP
460
KLQGIAQQNS FKHT
Length:464
Mass (Da):52,401
Last modified:December 6, 2005 - v1
Checksum:i794788AEE7F9A6E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB63509.1.
RefSeqiWP_011378884.1. NC_007606.1.
YP_405000.1. NC_007606.1.

Genome annotation databases

EnsemblBacteriaiABB63509; ABB63509; SDY_3532.
GeneIDi3798133.
KEGGisdy:SDY_3532.
PATRICi18697598. VBIShiDys99784_4187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA. Translation: ABB63509.1.
RefSeqiWP_011378884.1. NC_007606.1.
YP_405000.1. NC_007606.1.

3D structure databases

ProteinModelPortaliQ32AZ6.
SMRiQ32AZ6. Positions 44-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300267.SDY_3532.

Proteomic databases

PaxDbiQ32AZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB63509; ABB63509; SDY_3532.
GeneIDi3798133.
KEGGisdy:SDY_3532.
PATRICi18697598. VBIShiDys99784_4187.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG618QPT.

Enzyme and pathway databases

BioCyciSDYS300267:GJEW-3528-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sd197Imported.

Entry informationi

Entry nameiQ32AZ6_SHIDS
AccessioniPrimary (citable) accession number: Q32AZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 29, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.