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Q32AB8

- ARGE_SHIDS

UniProt

Q32AB8 - ARGE_SHIDS

Protein

Acetylornithine deacetylase

Gene

argE

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

    Cofactori

    Binds 2 zinc or cobalt ions per subunit.UniRule annotation
    Glutathione.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Cobalt or zinc 1UniRule annotation
    Active sitei82 – 821UniRule annotation
    Metal bindingi112 – 1121Cobalt or zinc 1UniRule annotation
    Metal bindingi112 – 1121Cobalt or zinc 2UniRule annotation
    Active sitei144 – 1441UniRule annotation
    Metal bindingi145 – 1451Cobalt or zinc 2UniRule annotation
    Metal bindingi169 – 1691Cobalt or zinc 1UniRule annotation
    Metal bindingi355 – 3551Cobalt or zinc 2UniRule annotation

    GO - Molecular functioni

    1. acetylornithine deacetylase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. metallopeptidase activity Source: InterPro
    4. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    Cobalt, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSDYS300267:GJEW-3788-MONOMER.
    UniPathwayiUPA00068; UER00110.

    Protein family/group databases

    MEROPSiM20.974.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
    Short name:
    AOUniRule annotation
    Short name:
    AcetylornithinaseUniRule annotation
    Alternative name(s):
    N-acetylornithinaseUniRule annotation
    Short name:
    NAOUniRule annotation
    Gene namesi
    Name:argEUniRule annotation
    Ordered Locus Names:SDY_3792
    OrganismiShigella dysenteriae serotype 1 (strain Sd197)
    Taxonomic identifieri300267 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000002716: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Acetylornithine deacetylasePRO_1000065062Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi300267.SDY_3792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ32AB8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0624.
    HOGENOMiHOG000243769.
    KOiK01438.
    OMAiPIRMHKG.
    OrthoDBiEOG60651W.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_01108. ArgE.
    InterProiIPR010169. AcOrn-deacetyl.
    IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q32AB8-1 [UniParc]FASTAAdd to Basket

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    MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKNLGFNV    50
    EVQPVPGTRN KFNMLASTGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE 100
    HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG 150
    ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA 200
    RGVNAIELMH DAIGHILQLR DSLKERYHYE AFTVPYPTLN LGHIHGGDAS 250
    NRICACCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP 300
    PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS 350
    INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH 383
    Length:383
    Mass (Da):42,307
    Last modified:December 6, 2005 - v1
    Checksum:iD306D4FEAB322410
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000034 Genomic DNA. Translation: ABB63737.1.
    RefSeqiYP_405228.1. NC_007606.1.

    Genome annotation databases

    EnsemblBacteriaiABB63737; ABB63737; SDY_3792.
    GeneIDi3798518.
    KEGGisdy:SDY_3792.
    PATRICi18698217. VBIShiDys99784_4481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000034 Genomic DNA. Translation: ABB63737.1 .
    RefSeqi YP_405228.1. NC_007606.1.

    3D structure databases

    ProteinModelPortali Q32AB8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300267.SDY_3792.

    Protein family/group databases

    MEROPSi M20.974.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB63737 ; ABB63737 ; SDY_3792 .
    GeneIDi 3798518.
    KEGGi sdy:SDY_3792.
    PATRICi 18698217. VBIShiDys99784_4481.

    Phylogenomic databases

    eggNOGi COG0624.
    HOGENOMi HOG000243769.
    KOi K01438.
    OMAi PIRMHKG.
    OrthoDBi EOG60651W.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00110 .
    BioCyci SDYS300267:GJEW-3788-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_01108. ArgE.
    InterProi IPR010169. AcOrn-deacetyl.
    IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01892. AcOrn-deacetyl. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sd197.

    Entry informationi

    Entry nameiARGE_SHIDS
    AccessioniPrimary (citable) accession number: Q32AB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3