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Q32AB8

- ARGE_SHIDS

UniProt

Q32AB8 - ARGE_SHIDS

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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

Cofactori

Binds 2 zinc or cobalt ions per subunit.UniRule annotation
Glutathione.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Cobalt or zinc 1UniRule annotation
Active sitei82 – 821UniRule annotation
Metal bindingi112 – 1121Cobalt or zinc 1UniRule annotation
Metal bindingi112 – 1121Cobalt or zinc 2UniRule annotation
Active sitei144 – 1441UniRule annotation
Metal bindingi145 – 1451Cobalt or zinc 2UniRule annotation
Metal bindingi169 – 1691Cobalt or zinc 1UniRule annotation
Metal bindingi355 – 3551Cobalt or zinc 2UniRule annotation

GO - Molecular functioni

  1. acetylornithine deacetylase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. metallopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSDYS300267:GJEW-3788-MONOMER.
UniPathwayiUPA00068; UER00110.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
Ordered Locus Names:SDY_3792
OrganismiShigella dysenteriae serotype 1 (strain Sd197)
Taxonomic identifieri300267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000002716: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Acetylornithine deacetylasePRO_1000065062Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi300267.SDY_3792.

Structurei

3D structure databases

ProteinModelPortaliQ32AB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0624.
HOGENOMiHOG000243769.
KOiK01438.
OMAiPIRMHKG.
OrthoDBiEOG60651W.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q32AB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKNLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHILQLR DSLKERYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP
310 320 330 340 350
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH
Length:383
Mass (Da):42,307
Last modified:December 6, 2005 - v1
Checksum:iD306D4FEAB322410
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000034 Genomic DNA. Translation: ABB63737.1.
RefSeqiYP_405228.1. NC_007606.1.

Genome annotation databases

EnsemblBacteriaiABB63737; ABB63737; SDY_3792.
GeneIDi3798518.
KEGGisdy:SDY_3792.
PATRICi18698217. VBIShiDys99784_4481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000034 Genomic DNA. Translation: ABB63737.1 .
RefSeqi YP_405228.1. NC_007606.1.

3D structure databases

ProteinModelPortali Q32AB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300267.SDY_3792.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB63737 ; ABB63737 ; SDY_3792 .
GeneIDi 3798518.
KEGGi sdy:SDY_3792.
PATRICi 18698217. VBIShiDys99784_4481.

Phylogenomic databases

eggNOGi COG0624.
HOGENOMi HOG000243769.
KOi K01438.
OMAi PIRMHKG.
OrthoDBi EOG60651W.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00110 .
BioCyci SDYS300267:GJEW-3788-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_01108. ArgE.
InterProi IPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sd197.

Entry informationi

Entry nameiARGE_SHIDS
AccessioniPrimary (citable) accession number: Q32AB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3