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Q321F0

- AROD_SHIBS

UniProt

Q321F0 - AROD_SHIBS

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Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Shigella boydii serotype 4 (strain Sb227)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821SubstrateUniRule annotation
Active sitei143 – 1431Proton donor/acceptorUniRule annotation
Active sitei170 – 1701Schiff-base intermediate with substrateUniRule annotation
Binding sitei213 – 2131SubstrateUniRule annotation
Binding sitei232 – 2321SubstrateUniRule annotation
Binding sitei236 – 2361SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciSBOY300268:GJFL-1435-MONOMER.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Alternative name(s):
Type I DHQaseUniRule annotation
Gene namesi
Name:aroDUniRule annotation
Ordered Locus Names:SBO_1438
OrganismiShigella boydii serotype 4 (strain Sb227)
Taxonomic identifieri300268 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000007067: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522523-dehydroquinate dehydratasePRO_1000043180Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi300268.SBO_1438.

Structurei

3D structure databases

ProteinModelPortaliQ321F0.
SMRiQ321F0. Positions 1-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 483Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the type-I 3-dehydroquinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0710.
HOGENOMiHOG000105514.
KOiK03785.
OMAiEGMPKII.
OrthoDBiEOG6P33BK.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00214. AroD.
InterProiIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamiPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01093. aroD. 1 hit.
PROSITEiPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q321F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTVTVKDLV IGTGAPKIIV SLMAKDIARV KSEALAYREA DFDILEWRVD
60 70 80 90 100
HFADLSNVES VMAAAKILRE TMPEKPLLFT FRSAKEGGEQ AISTEAYIAL
110 120 130 140 150
NRAAIDSGLV DMIDLELFTG DDQVKETVAC AHAHDVKVVM SNHDFHKTPE
160 170 180 190 200
AEEIIARLRK MQSFDADIPK IALMPQSTSD VLTLLAATLE MQEQYADRPI
210 220 230 240 250
ITMSMAKTGV ISRLAGEVFG SAATFGAVKK ASAPGQISVN DLRTVLTILH

QA
Length:252
Mass (Da):27,460
Last modified:December 6, 2005 - v1
Checksum:i144849291EB9004B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000036 Genomic DNA. Translation: ABB66058.1.
RefSeqiYP_407886.1. NC_007613.1.

Genome annotation databases

EnsemblBacteriaiABB66058; ABB66058; SBO_1438.
GeneIDi3780421.
KEGGisbo:SBO_1438.
PATRICi18681872. VBIShiBoy33460_1871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000036 Genomic DNA. Translation: ABB66058.1 .
RefSeqi YP_407886.1. NC_007613.1.

3D structure databases

ProteinModelPortali Q321F0.
SMRi Q321F0. Positions 1-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300268.SBO_1438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB66058 ; ABB66058 ; SBO_1438 .
GeneIDi 3780421.
KEGGi sbo:SBO_1438.
PATRICi 18681872. VBIShiBoy33460_1871.

Phylogenomic databases

eggNOGi COG0710.
HOGENOMi HOG000105514.
KOi K03785.
OMAi EGMPKII.
OrthoDBi EOG6P33BK.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00086 .
BioCyci SBOY300268:GJFL-1435-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00214. AroD.
InterProi IPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view ]
Pfami PF01487. DHquinase_I. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01093. aroD. 1 hit.
PROSITEi PS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sb227.

Entry informationi

Entry nameiAROD_SHIBS
AccessioniPrimary (citable) accession number: Q321F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3