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Q321F0

- AROD_SHIBS

UniProt

Q321F0 - AROD_SHIBS

Protein

3-dehydroquinate dehydratase

Gene

aroD

Organism
Shigella boydii serotype 4 (strain Sb227)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    3-dehydroquinate = 3-dehydroshikimate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821SubstrateUniRule annotation
    Active sitei143 – 1431Proton donor/acceptorUniRule annotation
    Active sitei170 – 1701Schiff-base intermediate with substrateUniRule annotation
    Binding sitei213 – 2131SubstrateUniRule annotation
    Binding sitei232 – 2321SubstrateUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-dehydroquinate dehydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciSBOY300268:GJFL-1435-MONOMER.
    UniPathwayiUPA00053; UER00086.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
    Short name:
    3-dehydroquinaseUniRule annotation
    Alternative name(s):
    Type I DHQaseUniRule annotation
    Gene namesi
    Name:aroDUniRule annotation
    Ordered Locus Names:SBO_1438
    OrganismiShigella boydii serotype 4 (strain Sb227)
    Taxonomic identifieri300268 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000007067: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2522523-dehydroquinate dehydratasePRO_1000043180Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi300268.SBO_1438.

    Structurei

    3D structure databases

    ProteinModelPortaliQ321F0.
    SMRiQ321F0. Positions 1-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni46 – 483Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the type-I 3-dehydroquinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0710.
    HOGENOMiHOG000105514.
    KOiK03785.
    OMAiEGMPKII.
    OrthoDBiEOG6P33BK.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00214. AroD.
    InterProiIPR018508. 3-dehydroquinate_DH_AS.
    IPR013785. Aldolase_TIM.
    IPR001381. DHquinase_I.
    [Graphical view]
    PfamiPF01487. DHquinase_I. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01093. aroD. 1 hit.
    PROSITEiPS01028. DEHYDROQUINASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q321F0-1 [UniParc]FASTAAdd to Basket

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    MKTVTVKDLV IGTGAPKIIV SLMAKDIARV KSEALAYREA DFDILEWRVD    50
    HFADLSNVES VMAAAKILRE TMPEKPLLFT FRSAKEGGEQ AISTEAYIAL 100
    NRAAIDSGLV DMIDLELFTG DDQVKETVAC AHAHDVKVVM SNHDFHKTPE 150
    AEEIIARLRK MQSFDADIPK IALMPQSTSD VLTLLAATLE MQEQYADRPI 200
    ITMSMAKTGV ISRLAGEVFG SAATFGAVKK ASAPGQISVN DLRTVLTILH 250
    QA 252
    Length:252
    Mass (Da):27,460
    Last modified:December 6, 2005 - v1
    Checksum:i144849291EB9004B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000036 Genomic DNA. Translation: ABB66058.1.
    RefSeqiYP_407886.1. NC_007613.1.

    Genome annotation databases

    EnsemblBacteriaiABB66058; ABB66058; SBO_1438.
    GeneIDi3780421.
    KEGGisbo:SBO_1438.
    PATRICi18681872. VBIShiBoy33460_1871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000036 Genomic DNA. Translation: ABB66058.1 .
    RefSeqi YP_407886.1. NC_007613.1.

    3D structure databases

    ProteinModelPortali Q321F0.
    SMRi Q321F0. Positions 1-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300268.SBO_1438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB66058 ; ABB66058 ; SBO_1438 .
    GeneIDi 3780421.
    KEGGi sbo:SBO_1438.
    PATRICi 18681872. VBIShiBoy33460_1871.

    Phylogenomic databases

    eggNOGi COG0710.
    HOGENOMi HOG000105514.
    KOi K03785.
    OMAi EGMPKII.
    OrthoDBi EOG6P33BK.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00086 .
    BioCyci SBOY300268:GJFL-1435-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00214. AroD.
    InterProi IPR018508. 3-dehydroquinate_DH_AS.
    IPR013785. Aldolase_TIM.
    IPR001381. DHquinase_I.
    [Graphical view ]
    Pfami PF01487. DHquinase_I. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01093. aroD. 1 hit.
    PROSITEi PS01028. DEHYDROQUINASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sb227.

    Entry informationi

    Entry nameiAROD_SHIBS
    AccessioniPrimary (citable) accession number: Q321F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3