Reviewed,
UniProtKB/Swiss-Prot Q31VL3 (RTCA_SHIBS)
Last modified
February 9, 2010.
Version 31.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable RNA 3'-terminal phosphate cyclase Short name=RNA-3'-phosphate cyclase Short name=RNA cyclase EC=6.5.1.4 | ||||
| Gene names |
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| Organism | Shigella boydii serotype 4 (strain Sb227) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 300268 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella |
Protein attributes
| Sequence length | 338 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing By similarity. HAMAP MF_00200 |
| Catalytic activity | ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. HAMAP MF_00200 |
| Subcellular location | Cytoplasm Potential HAMAP MF_00200. |
| Sequence similarities | Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | RNA processing Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasmInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA-3'-phosphate cyclase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 338 | 338 | Probable RNA 3'-terminal phosphate cyclase HAMAP MF_00200 | PRO_0000264798 | |||||
Sites | |||||||||
| Active site | 308 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery." Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J. Jin Q.Nucleic Acids Res. 33:6445-6458(2005) [PubMed: 16275786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000036 Genomic DNA. Translation: ABB67895.1. Different initiation. |
| RefSeq | YP_409723.1. |
3D structure databases | |
| SMR | Q31VL3. Positions 4-338. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3782391. |
| GenomeReviews | Gene locus SBO_3408 in contig CP000036_GR. |
| KEGG | sbo:SBO_3408. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG683539. |
| OMA | EIDGSYG. |
| PhylomeDB | Q31VL3. |
Enzyme and pathway databases | |
| BioCyc | SBOY300268:SBO_3408-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00200. RTC. [Tree] |
| InterPro | IPR013791. RNA3'-term_phos_cycl_insert. IPR000228. RNA3'_term_phos_cycl-like. IPR020719. RNA3'_term_phos_cycl-like_CS. IPR013796. RNA3'_term_phos_cycl_insert. IPR020723. RNA3'_term_phos_cycl_prd. IPR017770. RNA3'_term_phos_cycl_sub. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view] |
| Gene3D | G3DSA:3.65.10.20. RNA3'_term_phos_cycl. 1 hit. |
| PANTHER | PTHR11096. RNA3'_term_phos_cycl. 1 hit. |
| Pfam | PF01137. RTC. 1 hit. PF05189. RTC_insert. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03399. RNA_3prim_cycl. 1 hit. |
| PROSITE | PS01287. RTC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RTCA_SHIBS | ||||||||
| Accession | Primary (citable) accession number: Q31VL3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


