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Q31QJ2

- GSA_SYNE7

UniProt

Q31QJ2 - GSA_SYNE7

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Synpcc7942_0645
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0645-MONOMER.
UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Synpcc7942_0645
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 433432Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000243631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ31QJ2.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0645.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2213
Helixi24 – 263
Beta strandi27 – 293
Helixi30 – 323
Helixi35 – 373
Beta strandi44 – 496
Beta strandi51 – 544
Beta strandi59 – 646
Helixi65 – 673
Helixi77 – 8711
Helixi98 – 11013
Beta strandi115 – 1228
Helixi123 – 13816
Beta strandi142 – 1465
Helixi155 – 1573
Helixi164 – 1685
Beta strandi174 – 1763
Helixi178 – 1814
Beta strandi184 – 1874
Helixi192 – 20110
Turni203 – 2053
Beta strandi206 – 2116
Beta strandi213 – 2153
Helixi227 – 23711
Beta strandi241 – 2455
Turni247 – 2526
Helixi257 – 2615
Beta strandi267 – 2726
Helixi273 – 2764
Beta strandi282 – 2865
Helixi288 – 2914
Turni295 – 2973
Beta strandi298 – 3003
Helixi310 – 32314
Helixi328 – 35023
Beta strandi355 – 3595
Beta strandi362 – 3687
Helixi375 – 3784
Helixi383 – 39513
Helixi416 – 43116

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HOYX-ray2.20A/B2-433[»]
2HOZX-ray2.20A/B2-433[»]
2HP1X-ray2.08A/B2-433[»]
2HP2X-ray2.70A/B2-433[»]
3USFX-ray2.46A/B7-433[»]
ProteinModelPortaliQ31QJ2.
SMRiQ31QJ2. Positions 7-433.

Miscellaneous databases

EvolutionaryTraceiQ31QJ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31QJ2-1 [UniParc]FASTAAdd to Basket

« Hide

MVTSSPFKTI KSDEIFAAAQ KLMPGGVSSP VRAFKSVGGQ PIVFDRVKDA    50
YAWDVDGNRY IDYVGTWGPA ICGHAHPEVI EALKVAMEKG TSFGAPCALE 100
NVLAEMVIDA VPSIEMVRFV NSGTEACMAV LRLMRAYTGR DKIIKFEGCY 150
HGHADMFLVK AGSGVATLGL PDSPGVPKST TANTLTAPYN DLEAVKALFA 200
ENPGEIAGVI LEPIVGNSGF IVPDAGFLEG LREITLEHDA LLVFDEVMTG 250
FRIAYGGVQE KFGVTPDLTT LGKIIGGGLP VGAYGGKREI MQLVAPAGPM 300
YQAGTLSGNP LAMTAGIKTL ELLRQPGTYE YLDQITKRLS DGLLAIAQET 350
GHAACGGQVS GMFGFFFTEG PVHNYEDAKK SDLQKFSRFH RGMLEQGIYL 400
APSQFEAGFT SLAHTEEDID ATLAAARTVM SAL 433
Length:433
Mass (Da):46,102
Last modified:January 23, 2007 - v3
Checksum:i011176D3DF81275A
GO

Sequence cautioni

The sequence ABB56677.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000100 Genomic DNA. Translation: ABB56677.1. Different initiation.
RefSeqiYP_399664.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56677; ABB56677; Synpcc7942_0645.
GeneIDi3775628.
KEGGisyf:Synpcc7942_0645.
PATRICi23786439. VBISynElo51371_0756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000100 Genomic DNA. Translation: ABB56677.1 . Different initiation.
RefSeqi YP_399664.1. NC_007604.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HOY X-ray 2.20 A/B 2-433 [» ]
2HOZ X-ray 2.20 A/B 2-433 [» ]
2HP1 X-ray 2.08 A/B 2-433 [» ]
2HP2 X-ray 2.70 A/B 2-433 [» ]
3USF X-ray 2.46 A/B 7-433 [» ]
ProteinModelPortali Q31QJ2.
SMRi Q31QJ2. Positions 7-433.
ModBasei Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0645.

Proteomic databases

PRIDEi Q31QJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56677 ; ABB56677 ; Synpcc7942_0645 .
GeneIDi 3775628.
KEGGi syf:Synpcc7942_0645.
PATRICi 23786439. VBISynElo51371_0756.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .
BioCyci SYNEL:SYNPCC7942_0645-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q31QJ2.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiGSA_SYNE7
AccessioniPrimary (citable) accession number: Q31QJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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