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Q31QJ2

- GSA_SYNE7

UniProt

Q31QJ2 - GSA_SYNE7

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0645-MONOMER.
UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Synpcc7942_0645
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 433432Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000243631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ31QJ2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0645.

Structurei

Secondary structure

1
433
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2213Combined sources
Helixi24 – 263Combined sources
Beta strandi27 – 293Combined sources
Helixi30 – 323Combined sources
Helixi35 – 373Combined sources
Beta strandi44 – 496Combined sources
Beta strandi51 – 544Combined sources
Beta strandi59 – 646Combined sources
Helixi65 – 673Combined sources
Helixi77 – 8711Combined sources
Helixi98 – 11013Combined sources
Beta strandi115 – 1228Combined sources
Helixi123 – 13816Combined sources
Beta strandi142 – 1465Combined sources
Helixi155 – 1573Combined sources
Helixi164 – 1685Combined sources
Beta strandi174 – 1763Combined sources
Helixi178 – 1814Combined sources
Beta strandi184 – 1874Combined sources
Helixi192 – 20110Combined sources
Turni203 – 2053Combined sources
Beta strandi206 – 2116Combined sources
Beta strandi213 – 2153Combined sources
Helixi227 – 23711Combined sources
Beta strandi241 – 2455Combined sources
Turni247 – 2526Combined sources
Helixi257 – 2615Combined sources
Beta strandi267 – 2726Combined sources
Helixi273 – 2764Combined sources
Beta strandi282 – 2865Combined sources
Helixi288 – 2914Combined sources
Turni295 – 2973Combined sources
Beta strandi298 – 3003Combined sources
Helixi310 – 32314Combined sources
Helixi328 – 35023Combined sources
Beta strandi355 – 3595Combined sources
Beta strandi362 – 3687Combined sources
Helixi375 – 3784Combined sources
Helixi383 – 39513Combined sources
Helixi416 – 43116Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3USFX-ray2.46A/B7-433[»]
ProteinModelPortaliQ31QJ2.
SMRiQ31QJ2. Positions 7-433.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ31QJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31QJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTSSPFKTI KSDEIFAAAQ KLMPGGVSSP VRAFKSVGGQ PIVFDRVKDA
60 70 80 90 100
YAWDVDGNRY IDYVGTWGPA ICGHAHPEVI EALKVAMEKG TSFGAPCALE
110 120 130 140 150
NVLAEMVIDA VPSIEMVRFV NSGTEACMAV LRLMRAYTGR DKIIKFEGCY
160 170 180 190 200
HGHADMFLVK AGSGVATLGL PDSPGVPKST TANTLTAPYN DLEAVKALFA
210 220 230 240 250
ENPGEIAGVI LEPIVGNSGF IVPDAGFLEG LREITLEHDA LLVFDEVMTG
260 270 280 290 300
FRIAYGGVQE KFGVTPDLTT LGKIIGGGLP VGAYGGKREI MQLVAPAGPM
310 320 330 340 350
YQAGTLSGNP LAMTAGIKTL ELLRQPGTYE YLDQITKRLS DGLLAIAQET
360 370 380 390 400
GHAACGGQVS GMFGFFFTEG PVHNYEDAKK SDLQKFSRFH RGMLEQGIYL
410 420 430
APSQFEAGFT SLAHTEEDID ATLAAARTVM SAL
Length:433
Mass (Da):46,102
Last modified:January 23, 2007 - v3
Checksum:i011176D3DF81275A
GO

Sequence cautioni

The sequence ABB56677.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000100 Genomic DNA. Translation: ABB56677.1. Different initiation.
RefSeqiYP_399664.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56677; ABB56677; Synpcc7942_0645.
GeneIDi3775628.
KEGGisyf:Synpcc7942_0645.
PATRICi23786439. VBISynElo51371_0756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000100 Genomic DNA. Translation: ABB56677.1 . Different initiation.
RefSeqi YP_399664.1. NC_007604.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3USF X-ray 2.46 A/B 7-433 [» ]
ProteinModelPortali Q31QJ2.
SMRi Q31QJ2. Positions 7-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0645.

Proteomic databases

PRIDEi Q31QJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56677 ; ABB56677 ; Synpcc7942_0645 .
GeneIDi 3775628.
KEGGi syf:Synpcc7942_0645.
PATRICi 23786439. VBISynElo51371_0756.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .
BioCyci SYNEL:SYNPCC7942_0645-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q31QJ2.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiGSA_SYNE7
AccessioniPrimary (citable) accession number: Q31QJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3