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Q31PY6

- DAPAT_SYNE7

UniProt

Q31PY6 - DAPAT_SYNE7

Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Substrate; via amide nitrogenUniRule annotation
    Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
    Binding sitei75 – 751Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Binding sitei187 – 1871Pyridoxal phosphateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei215 – 2151Pyridoxal phosphateUniRule annotation
    Binding sitei218 – 2181Pyridoxal phosphateUniRule annotation
    Binding sitei246 – 2461Pyridoxal phosphateUniRule annotation
    Binding sitei248 – 2481Pyridoxal phosphateUniRule annotation
    Binding sitei257 – 2571Pyridoxal phosphateUniRule annotation
    Binding sitei292 – 2921Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei388 – 3881SubstrateUniRule annotation

    GO - Molecular functioni

    1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_0853-MONOMER.
    UniPathwayiUPA00034; UER00466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
    Short name:
    DAP-ATUniRule annotation
    Short name:
    DAP-aminotransferaseUniRule annotation
    Short name:
    LL-DAP-aminotransferaseUniRule annotation
    Gene namesi
    Name:dapLUniRule annotation
    Ordered Locus Names:Synpcc7942_0853
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411LL-diaminopimelate aminotransferasePRO_0000312550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei249 – 2491N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_0853.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31PY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223061.
    KOiK10206.
    OrthoDBiEOG6XWV2X.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01642. DapL_aminotrans_1.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q31PY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATINDNYLK LKAGYLFPEI ARRVNAFAQS NPEAAIIRLG IGDVTEPLPV    50
    ACRQAMIQAV EDMGQRENFK GYGPEQGYAW LREKIAAHDF QSRGCEVDAS 100
    EIFISDGSKC DCGNILDIFG NNNRIAVTDP VYPVYVDTNV MAGHTGDAND 150
    RGEYDGLVYL PISAENNFTA EIPSEKVDLI YLCFPNNPTG AVASREYLQA 200
    WVDYARANGA IILFDAAYEA FITDPAIPHS IFEIPGARDC AIEFRSFSKN 250
    AGFTGTRCAF TVVPKGLKGK AADGSEVELW GLWNRRQSTK FNGVSYIVQR 300
    GAEAVYSAEG QAQIKELVAF YLENARIIRE ELTAAGLDVH GGVNAPYVWV 350
    KTPAGLTSWD FFDKLLQVCN VVGTPGSGFG AAGEGYFRIS AFNSRENVVT 400
    AMQRIRSAGL A 411
    Length:411
    Mass (Da):44,846
    Last modified:December 6, 2005 - v1
    Checksum:i3BCDA337CE482057
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000100 Genomic DNA. Translation: ABB56883.1.
    RefSeqiYP_399870.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB56883; ABB56883; Synpcc7942_0853.
    GeneIDi3774029.
    KEGGisyf:Synpcc7942_0853.
    PATRICi23786923. VBISynElo51371_0995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000100 Genomic DNA. Translation: ABB56883.1 .
    RefSeqi YP_399870.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali Q31PY6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_0853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB56883 ; ABB56883 ; Synpcc7942_0853 .
    GeneIDi 3774029.
    KEGGi syf:Synpcc7942_0853.
    PATRICi 23786923. VBISynElo51371_0995.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223061.
    KOi K10206.
    OrthoDBi EOG6XWV2X.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00466 .
    BioCyci SYNEL:SYNPCC7942_0853-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01642. DapL_aminotrans_1.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR019942. DapL_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiDAPAT_SYNE7
    AccessioniPrimary (citable) accession number: Q31PY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3