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Q31PY6

- DAPAT_SYNE7

UniProt

Q31PY6 - DAPAT_SYNE7

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Protein

LL-diaminopimelate aminotransferase

Gene
dapL, Synpcc7942_0853
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogen By similarity
Binding sitei72 – 721Pyridoxal phosphate; shared with dimeric partner By similarity
Binding sitei75 – 751Substrate; shared with dimeric partner By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei187 – 1871Pyridoxal phosphate By similarity
Binding sitei187 – 1871Substrate By similarity
Binding sitei215 – 2151Pyridoxal phosphate By similarity
Binding sitei218 – 2181Pyridoxal phosphate By similarity
Binding sitei246 – 2461Pyridoxal phosphate By similarity
Binding sitei248 – 2481Pyridoxal phosphate By similarity
Binding sitei257 – 2571Pyridoxal phosphate By similarity
Binding sitei292 – 2921Substrate; shared with dimeric partner By similarity
Binding sitei388 – 3881Substrate By similarity

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0853-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase (EC:2.6.1.83)
Short name:
DAP-AT
Short name:
DAP-aminotransferase
Short name:
LL-DAP-aminotransferase
Gene namesi
Name:dapL
Ordered Locus Names:Synpcc7942_0853
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411LL-diaminopimelate aminotransferaseUniRule annotationPRO_0000312550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0853.

Structurei

3D structure databases

ProteinModelPortaliQ31PY6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223061.
KOiK10206.
OrthoDBiEOG6XWV2X.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11751:SF22. PTHR11751:SF22. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03542. DAPAT_plant. 1 hit.

Sequencei

Sequence statusi: Complete.

Q31PY6-1 [UniParc]FASTAAdd to Basket

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MATINDNYLK LKAGYLFPEI ARRVNAFAQS NPEAAIIRLG IGDVTEPLPV    50
ACRQAMIQAV EDMGQRENFK GYGPEQGYAW LREKIAAHDF QSRGCEVDAS 100
EIFISDGSKC DCGNILDIFG NNNRIAVTDP VYPVYVDTNV MAGHTGDAND 150
RGEYDGLVYL PISAENNFTA EIPSEKVDLI YLCFPNNPTG AVASREYLQA 200
WVDYARANGA IILFDAAYEA FITDPAIPHS IFEIPGARDC AIEFRSFSKN 250
AGFTGTRCAF TVVPKGLKGK AADGSEVELW GLWNRRQSTK FNGVSYIVQR 300
GAEAVYSAEG QAQIKELVAF YLENARIIRE ELTAAGLDVH GGVNAPYVWV 350
KTPAGLTSWD FFDKLLQVCN VVGTPGSGFG AAGEGYFRIS AFNSRENVVT 400
AMQRIRSAGL A 411
Length:411
Mass (Da):44,846
Last modified:December 6, 2005 - v1
Checksum:i3BCDA337CE482057
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000100 Genomic DNA. Translation: ABB56883.1.
RefSeqiYP_399870.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56883; ABB56883; Synpcc7942_0853.
GeneIDi3774029.
KEGGisyf:Synpcc7942_0853.
PATRICi23786923. VBISynElo51371_0995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000100 Genomic DNA. Translation: ABB56883.1 .
RefSeqi YP_399870.1. NC_007604.1.

3D structure databases

ProteinModelPortali Q31PY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56883 ; ABB56883 ; Synpcc7942_0853 .
GeneIDi 3774029.
KEGGi syf:Synpcc7942_0853.
PATRICi 23786923. VBISynElo51371_0995.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223061.
KOi K10206.
OrthoDBi EOG6XWV2X.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci SYNEL:SYNPCC7942_0853-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019942. DapL_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11751:SF22. PTHR11751:SF22. 1 hit.
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03542. DAPAT_plant. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiDAPAT_SYNE7
AccessioniPrimary (citable) accession number: Q31PY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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