Q31NA0 (NU4C1_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase chain 4 1
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase I, chain 4 1
NDH-1, chain 4 1

Gene names

Name:	ndhD1
Ordered Locus Names:	Synpcc7942_1439

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00491
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP-Rule MF_00491
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00491.
Sequence similarities	Belongs to the complex I subunit 4 family.

Ontologies

Keywords
Cellular component	Membrane Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 533	533	NAD(P)H-quinone oxidoreductase chain 4 1 HAMAP-Rule MF_00491		PRO_0000343260
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	137 – 157	21	Helical; Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential
	Transmembrane	277 – 297	21	Helical; Potential
	Transmembrane	311 – 331	21	Helical; Potential
	Transmembrane	332 – 352	21	Helical; Potential
	Transmembrane	376 – 396	21	Helical; Potential
	Transmembrane	417 – 437	21	Helical; Potential
	Transmembrane	461 – 481	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q31NA0 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 7C32B474079FA418	FASTA	533	58,083
	10 20 30 40 50 60 MTSEQFPWLT GIILLPILAA LPIPLIPDKD GRTVRWYSLF VGLADFALMV YAFWQHFDRS 70 80 90 100 110 120 EAGLQMVEKI SWVPQIGLNW SLAVDGLSMP LVLLTGLVTT LAILASWNIN VKPKLFHFLL 130 140 150 160 170 180 LLLYGAQIAV FTAQDMMLFF LVWELELVPV YLLISIWGGP KRQYAATKFI LYTALASLFI 190 200 210 220 230 240 LVAGLALAFS GDSFSFDLTE LGLKDYSLWL ELLAYAGFLI AFGVKLSIFP LHTWLPDAHG 250 260 270 280 290 300 EANAPGSMLL AGILLKMGGY ALIRFNVQLL PEAHIRFAPV LAVLGIVNII YGALNAFAQD 310 320 330 340 350 360 NLKRKIAYSS ISHMGFVLLG IAAYNSLGLN GALLQMLSHG LIAAALFFLA GVAYERTHTL 370 380 390 400 410 420 QIPQISGLAK QMPITFALFT VTAMASLALP GMSGFVSELT VFLGFTDSVY SSGFRTVTIL 430 440 450 460 470 480 LAAVGLVLTP MYLLSMLRRI FYGTYNIQLG QVLADAKPRE LFVAFCLLVP TLAIGFYPKL 490 500 510 520 530 TTQVYDVTTT ALAAQVQSNL PVVALAQQGS LYSQMPAAEE ATAVSMTAPP VID

References

[1]

"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000100 Genomic DNA. Translation: ABB57469.1.
RefSeq	YP_400456.1. NC_007604.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	1140.Synpcc7942_1439.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB57469; ABB57469; Synpcc7942_1439.
GeneID	3773611.
KEGG	syf:Synpcc7942_1439.
PATRIC	23788231. VBISynElo51371_1642.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1008.
HOGENOM	HOG000100683.
KO	K05575.
ProtClustDB	PRK12561.
Enzyme and pathway databases
BioCyc	MetaCyc:SYNPCC7942_1439-MONOMER. SYNEL:SYNPCC7942_1439-MONOMER.
Family and domain databases
HAMAP	MF_00491. NDH1_NuoM.
InterPro	IPR022997. NADH_Q_OxRdtase_chain4. IPR010227. NADH_Q_OxRdtase_chainM/4. IPR001750. NADH_UbQ/plastoQ_OxRdtase. IPR003918. NADH_UbQ_OxRdtase. [Graphical view]
Pfam	PF00361. Oxidored_q1. 1 hit. [Graphical view]
PRINTS	PR01437. NUOXDRDTASE4.
TIGRFAMs	TIGR01972. NDH_I_M. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NU4C1_SYNE7

Accession

Primary (citable) accession number: Q31NA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	December 6, 2005
Last modified:	May 29, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program