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Protein

1,4-dihydroxy-2-naphthoyl-CoA hydrolase

Gene

Synpcc7942_1744

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.UniRule annotation

Catalytic activityi

1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA.UniRule annotation

Pathwayi: phylloquinone biosynthesis

This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phylloquinone biosynthesis and in Cofactor biosynthesis.

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (Synpcc7942_1744)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1744-MONOMER.
UniPathwayiUPA00995.
UPA01057; UER01033.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-dihydroxy-2-naphthoyl-CoA hydrolaseUniRule annotation (EC:3.1.2.28UniRule annotation)
Short name:
DHNA-CoA hydrolaseUniRule annotation
Alternative name(s):
DHNA-CoA thioesteraseUniRule annotation
Gene namesi
Ordered Locus Names:Synpcc7942_1744
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002717 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003770271 – 1361,4-dihydroxy-2-naphthoyl-CoA hydrolaseAdd BLAST136

Proteomic databases

PRIDEiQ31ME5.

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1744.

Structurei

3D structure databases

ProteinModelPortaliQ31ME5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WGP. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000056134.
KOiK12073.
OrthoDBiPOG091H02B8.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_02101. DHNA_CoA_hydrolase. 1 hit.
InterProiIPR022829. DHNA_CoA_hydrolase.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.

Sequencei

Sequence statusi: Complete.

Q31ME5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYQFQRVI RFGDTDAAGV VYFAQLLSIC HEAYEAAIAA LGIELRSFFS
60 70 80 90 100
DRGSVILPIV HAEIDYQRPT YCGDRLEIEL QATALGRDRF RVDYRLSHNH
110 120 130
QPVATAQTIH LCLESQTRQR SPLPERLQDW LQITAD
Length:136
Mass (Da):15,552
Last modified:December 6, 2005 - v1
Checksum:i844F2781E15247B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000100 Genomic DNA. Translation: ABB57774.1.
RefSeqiWP_011244657.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB57774; ABB57774; Synpcc7942_1744.
KEGGisyf:Synpcc7942_1744.
PATRICi23788903. VBISynElo51371_1975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000100 Genomic DNA. Translation: ABB57774.1.
RefSeqiWP_011244657.1. NC_007604.1.

3D structure databases

ProteinModelPortaliQ31ME5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1744.

Proteomic databases

PRIDEiQ31ME5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB57774; ABB57774; Synpcc7942_1744.
KEGGisyf:Synpcc7942_1744.
PATRICi23788903. VBISynElo51371_1975.

Phylogenomic databases

eggNOGiENOG4105WGP. Bacteria.
COG0824. LUCA.
HOGENOMiHOG000056134.
KOiK12073.
OrthoDBiPOG091H02B8.

Enzyme and pathway databases

UniPathwayiUPA00995.
UPA01057; UER01033.
BioCyciSYNEL:SYNPCC7942_1744-MONOMER.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_02101. DHNA_CoA_hydrolase. 1 hit.
InterProiIPR022829. DHNA_CoA_hydrolase.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDNCH_SYNE7
AccessioniPrimary (citable) accession number: Q31ME5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.