Q31M48 (Q31M48_SYNE7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136

Gene names

Ordered Locus Names:

Synpcc7942_1841 EMBL ABB57871.1

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP] EMBL ABB57871.1

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MurCDEF family. RuleBase RU003630

Ontologies

Keywords
Biological process	Cell cycle Cell division RuleBase RU004136 Cell shape Cell wall biogenesis/degradation RuleBase RU004136 Peptidoglycan synthesis RuleBase RU004136
Ligand	ATP-binding RuleBase RU003630 Nucleotide-binding
Molecular function	Ligase RuleBase RU003630 EMBL ABB57871.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Inferred from electronic annotation. Source: EC UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q31M48 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 63A08791A3A676C7	FASTA	455	49,117
	10 20 30 40 50 60 MATFFSPFQI QLGLGAIPLQ VGEACDRPAR SLTTDSRQIQ PGDIFLALRG DRFDGHDFVA 70 80 90 100 110 120 QALADGAIAA IVDRDYQPPS DLAAGHLLQV DNTLWAYQEV ARLWRQRCSL PLIGITGSVG 130 140 150 160 170 180 KTTTKELIAA MLAVRGPVLK TEANYNNEIG VPKTVLQIDP DHHWAAVLEM GMRGRGQIAE 190 200 210 220 230 240 LARIAQPNIA VITNVGTAHI GLLGSEQAIA EAKCELLAQL SGTGLAILNA DNHRLIATAQ 250 260 270 280 290 300 RLNLPRCRTY GLQNGDLQGQ LIDLETLVVE GQRFRLPLPG AHNALNFLAG LAIAQELGLD 310 320 330 340 350 360 WEAFRDLSVT LPQGRARRIE LSPDIVLLDE TYNAGLESML AALQLLADTP GQRRIAVLGT 370 380 390 400 410 420 MKELGDFSET YHRQVGEKAA ALGLDRLLIY ADPTEAAAMQ AGASAIATQI FTNAEDLLSE 430 440 450 LRQSVQTGDR LLFKASRSVA LDRILADFVA VYSAV

References

[1]

"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000100 Genomic DNA. Translation: ABB57871.1.
RefSeq	YP_400858.1. NC_007604.1.
3D structure databases
ProteinModelPortal	Q31M48.
ModBase	Search...
Protein-protein interaction databases
STRING	1140.Synpcc7942_1841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB57871; ABB57871; Synpcc7942_1841.
GeneID	3774416.
KEGG	syf:Synpcc7942_1841.
PATRIC	23789115. VBISynElo51371_2081.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000268120.
KO	K01929.
ProtClustDB	CLSK893146.
Enzyme and pathway databases
BioCyc	SELO1140:GJWQ-1869-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.40.1190.10. 1 hit. 3.90.190.20. 1 hit.
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR005863. UDP-N-AcMur-pentapeptide_synth. [Graphical view]
PANTHER	PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01143. murF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q31M48_SYNE7

Accession

Primary (citable) accession number: Q31M48

Entry history

Integrated into UniProtKB/TrEMBL:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)