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Q31LY2 (ACSF_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase

Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
EC=1.14.13.81
Gene names
Name:acsF
Ordered Locus Names:Synpcc7942_1907
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaChroococcalesSynechococcus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840

Catalytic activity

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Cofactor

Iron By similarity. HAMAP MF_01840

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840

Sequence similarities

Belongs to the AcsF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
PRO_1000070552

Sequences

Sequence LengthMass (Da)Tools
Q31LY2 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 6C047F45E9DAB3A2

FASTA35842,120
        10         20         30         40         50         60 
MVDSLQKPEL EELRPGIKAP AKETILTPRF YTTDFEAMAK MDLSPNEDEL RAILEEFRAD 

        70         80         90        100        110        120 
YNRKHFVRTP EFDGSAADMD PETKKVFVEF LEQSCTSEFS GFLLYKELSR RIKNRNPLLA 

       130        140        150        160        170        180 
ECFELMARDE ARHAGFLNKS MSDFDLQLDL GFLTANKKYT YFKPAYIFYA TYLSEKIGYW 

       190        200        210        220        230        240 
RYITIFRHLE QHPEYRIYPI FKFFENWCQD ENRHGDFFDA LMKAQPSTVR GFVAKLWCRF 

       250        260        270        280        290        300 
FLLAVFATMY IRDVQRKEFY EALGLDAREY DRHVIAKTNE TSARVFPVVL DVDHPKFYDR 

       310        320        330        340        350 
LETCIANNNQ LAAIEATSAP KPVKVLRKLP YYLSNGLQLL KLYLVKPLES DVYQPAVR 

« Hide

References

[1]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000100 Genomic DNA. Translation: ABB57937.1.
RefSeqYP_400924.1. NC_007604.1.

3D structure databases

ProteinModelPortalQ31LY2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ31LY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3775270.
GenomeReviewsGene locus Synpcc7942_1907 in contig CP000100_GR.
KEGGsyf:Synpcc7942_1907.
PATRIC23789257. VBISynElo51371_2152.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHBG284843.
PhylomeDBQ31LY2.
ProtClustDBPRK13654.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_1907-MONOMER.

Family and domain databases

HAMAPMF_01840. AcsF.
[Tree]
InterProIPR008434. AcsF.
IPR012347. Ferritin-rel.
IPR009078. Ferritin/RR-like.
IPR003251. Rubrerythrin.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KOK04035.
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACSF_SYNE7
AccessionPrimary (citable) accession number: Q31LY2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families