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Q31LS2

- UPPP_SYNE7

UniProt

Q31LS2 - UPPP_SYNE7

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_1967-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Synpcc7942_1967
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Undecaprenyl-diphosphatasePRO_0000250276Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_1967.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei49 – 6921HelicalUniRule annotationAdd
    BLAST
    Transmembranei94 – 11421HelicalUniRule annotationAdd
    BLAST
    Transmembranei129 – 14921HelicalUniRule annotationAdd
    BLAST
    Transmembranei159 – 17921HelicalUniRule annotationAdd
    BLAST
    Transmembranei199 – 21921HelicalUniRule annotationAdd
    BLAST
    Transmembranei234 – 25421HelicalUniRule annotationAdd
    BLAST
    Transmembranei265 – 28521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q31LS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIAVSSADR LDLWQAIVLG FVQGATEFLP ISSTAHLKVV PVVLGWGDPG    50
    VAFTAVIQLG SIVAVLSYFR QDLTYVLRGL VSAVRRQDFR SEPAQMGLGI 100
    LFGTIPILIG GLLIKRFIPD YDNSPLRSLA AIAIVSIVMG LLLGIAEQLS 150
    KHQRDLSQLR LADGLWMGFA QALALIPGVS RSGSTLTAGL FQGLKRDTAA 200
    RFSFLLGIPA ITIAGLVELK DLLEAGIDGS SLGVLAIGTL SSLIFSWLAI 250
    AWLLRFLRTH NTWSFVVYRI IFGGVILTAI ATGTLQNI 288
    Length:288
    Mass (Da):30,868
    Last modified:December 6, 2005 - v1
    Checksum:i348CDCD918336077
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000100 Genomic DNA. Translation: ABB57997.1.
    RefSeqiYP_400984.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB57997; ABB57997; Synpcc7942_1967.
    GeneIDi3774154.
    KEGGisyf:Synpcc7942_1967.
    PATRICi23789387. VBISynElo51371_2216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000100 Genomic DNA. Translation: ABB57997.1 .
    RefSeqi YP_400984.1. NC_007604.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_1967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB57997 ; ABB57997 ; Synpcc7942_1967 .
    GeneIDi 3774154.
    KEGGi syf:Synpcc7942_1967.
    PATRICi 23789387. VBISynElo51371_2216.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci SYNEL:SYNPCC7942_1967-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiUPPP_SYNE7
    AccessioniPrimary (citable) accession number: Q31LS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3