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Q31KL4 (DDL_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Synpcc7942_2375
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000030512

Regions

Domain133 – 342210ATP-grasp
Nucleotide binding169 – 22456ATP By similarity

Sites

Metal binding2961Magnesium or manganese 1 By similarity
Metal binding3091Magnesium or manganese 1 By similarity
Metal binding3091Magnesium or manganese 2 By similarity
Metal binding3111Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31KL4 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: C6C736BB4487C0FD

FASTA34737,902
        10         20         30         40         50         60 
MAAQKVGLLF GGRSGEHEVS IRSAAAIASA LADPSNRDRY QVLPFYIDKE GGWHSGETAA 

        70         80         90        100        110        120 
QVLANQKPLF VEEPSDRWQF PADCRDVEVW FPILHGPNGE DGTIQGLLTL MQRPFVGSGV 

       130        140        150        160        170        180 
LGSALGMDKI AMKQAFAQAS LPQVAYVAVN RSQVFSDPCR YTSLLEQIET ELGYPCFVKP 

       190        200        210        220        230        240 
ANLGSSVGIA KVRDRAELEA ALDQAAALDR RLIIEAAIDN PREVECAVLG NDYPQASILG 

       250        260        270        280        290        300 
EITYDSDFYD YETKYTDGKA QLLIPAQLSA ELQQKLQELA IAAFQAVDAS GLSRLDFFLD 

       310        320        330        340 
SQGQIFINEI NTLPGFTALS MYPQLWAASG VAFPDLVHRL IQLALER 

« Hide

References

[1]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000100 Genomic DNA. Translation: ABB58405.1.
RefSeqYP_401392.1. NC_007604.1.

3D structure databases

ProteinModelPortalQ31KL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_2375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB58405; ABB58405; Synpcc7942_2375.
GeneID3774658.
KEGGsyf:Synpcc7942_2375.
PATRIC23790305. VBISynElo51371_2667.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_2375-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_SYNE7
AccessionPrimary (citable) accession number: Q31KL4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways