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Q31K20

- PYRF_SYNE7

UniProt

Q31K20 - PYRF_SYNE7

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, Synpcc7942_2569
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Substrate By similarity
Binding sitei36 – 361Substrate By similarity
Active sitei65 – 651Proton donor By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Binding sitei198 – 1981Substrate By similarity
Binding sitei218 – 2181Substrate; via amide nitrogen By similarity
Binding sitei219 – 2191Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_2569-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Synpcc7942_2569
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000241922Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi1140.Synpcc7942_2569.

Structurei

3D structure databases

ProteinModelPortaliQ31K20.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 7210Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31K20-1 [UniParc]FASTAAdd to Basket

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MTDLAARDRI IVPLDVPDVE AAITLIDRLP EAQFFKVGLE LFVATGSTVL    50
TILKERQKKI FLDLKLHDIP NTMAGACRSA ARYGVDLLTI HATAGKPALE 100
AAQAGAIAGA AAAGVQPPTL LAVTVLTSLS QQQLTEELHV PEAVPNYVQH 150
LARQAEACGI GGCVCSPQEL VVLKTACSDD FVRVTPGVRP TWAAAGDQQR 200
VMTPQQAIAA GATYLVVGRP ITAADDPAAA FQRVCEELTP 240
Length:240
Mass (Da):25,268
Last modified:December 6, 2005 - v1
Checksum:iBB5CEE704D9AD910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000100 Genomic DNA. Translation: ABB58599.1.
RefSeqiYP_401586.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB58599; ABB58599; Synpcc7942_2569.
GeneIDi3775162.
KEGGisyf:Synpcc7942_2569.
PATRICi23790721. VBISynElo51371_2869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000100 Genomic DNA. Translation: ABB58599.1 .
RefSeqi YP_401586.1. NC_007604.1.

3D structure databases

ProteinModelPortali Q31K20.
ModBasei Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_2569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB58599 ; ABB58599 ; Synpcc7942_2569 .
GeneIDi 3775162.
KEGGi syf:Synpcc7942_2569.
PATRICi 23790721. VBISynElo51371_2869.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SYNEL:SYNPCC7942_2569-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiPYRF_SYNE7
AccessioniPrimary (citable) accession number: Q31K20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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