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Protein

Argininosuccinate lyase

Gene

argH

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-114-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Tcr_0110
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002407881 – 462Argininosuccinate lyaseAdd BLAST462

Proteomic databases

PRIDEiQ31JG7

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_0110

Structurei

3D structure databases

ProteinModelPortaliQ31JG7
SMRiQ31JG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q31JG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQHNQEKL SSARFSEATD AFVEEFTASI QFDKRMYRQD IQGSVAHAKM
60 70 80 90 100
LHKVGILDKQ ELKDIIDGLE KVQSDIEAGK MNWSIKQEDI HMNIEAKLTE
110 120 130 140 150
LIGITGKKLH TGRSRNDQVA TDIRLYLRDE IDAILPEMAR LQHGILLLAE
160 170 180 190 200
KEAETIMPGF THLQTAQPVT FGHHMMAWFE MIKRDVERLE DCRKRVNTMP
210 220 230 240 250
LGSAALAGTT YPIQREYTAE LLQFDRISEN SLDGVSDRDF AIEFTAFAAT
260 270 280 290 300
FLMHLSRFSE ELVLWSSAQF NFIDLPDRFC TGSSIMPQKK NPDVPELVRG
310 320 330 340 350
KTGRVYGHLM SLLTLMKSQP LAYNKDNQED KEPLFDTVDT VKGSLRAFAD
360 370 380 390 400
MVPAIIVNRE ATYAAAKQGF STATDLADYL VNKGLPFRDA HEVVGLAVAH
410 420 430 440 450
GIQTGQDLSE MPLETLQAFH SSITDDVFEV LTLEGSVSAR DHLGGTAPKQ
460
VKAAIKRAKD RL
Length:462
Mass (Da):51,817
Last modified:December 6, 2005 - v1
Checksum:iA358D69D5265D5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB40706.1
RefSeqiWP_011369532.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB40706; ABB40706; Tcr_0110
KEGGitcx:Tcr_0110

Similar proteinsi

Entry informationi

Entry nameiARLY_HYDCU
AccessioniPrimary (citable) accession number: Q31JG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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