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Q31JG7 (ARLY_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase

Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Tcr_0110
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_0000240788

Sequences

Sequence LengthMass (Da)Tools
Q31JG7 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: A358D69D5265D5CE

FASTA46251,817
        10         20         30         40         50         60 
MSNQHNQEKL SSARFSEATD AFVEEFTASI QFDKRMYRQD IQGSVAHAKM LHKVGILDKQ 

        70         80         90        100        110        120 
ELKDIIDGLE KVQSDIEAGK MNWSIKQEDI HMNIEAKLTE LIGITGKKLH TGRSRNDQVA 

       130        140        150        160        170        180 
TDIRLYLRDE IDAILPEMAR LQHGILLLAE KEAETIMPGF THLQTAQPVT FGHHMMAWFE 

       190        200        210        220        230        240 
MIKRDVERLE DCRKRVNTMP LGSAALAGTT YPIQREYTAE LLQFDRISEN SLDGVSDRDF 

       250        260        270        280        290        300 
AIEFTAFAAT FLMHLSRFSE ELVLWSSAQF NFIDLPDRFC TGSSIMPQKK NPDVPELVRG 

       310        320        330        340        350        360 
KTGRVYGHLM SLLTLMKSQP LAYNKDNQED KEPLFDTVDT VKGSLRAFAD MVPAIIVNRE 

       370        380        390        400        410        420 
ATYAAAKQGF STATDLADYL VNKGLPFRDA HEVVGLAVAH GIQTGQDLSE MPLETLQAFH 

       430        440        450        460 
SSITDDVFEV LTLEGSVSAR DHLGGTAPKQ VKAAIKRAKD RL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB40706.1.
RefSeqYP_390380.1. NC_007520.2.

3D structure databases

ProteinModelPortalQ31JG7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_0110.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB40706; ABB40706; Tcr_0110.
GeneID3762518.
KEGGtcx:Tcr_0110.
PATRIC23972088. VBIThiCru83387_0116.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMAWSSAQFN.
OrthoDBEOG6P5ZF8.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-110-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00149. FUMRATELYASE.
SUPFAMSSF48557. SSF48557. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_THICR
AccessionPrimary (citable) accession number: Q31JG7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways