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Q31JF8

- TRMB_THICR

UniProt

Q31JF8 - TRMB_THICR

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Tcr_0119
Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711S-adenosyl-L-methionine By similarity
Binding sitei96 – 961S-adenosyl-L-methionine By similarity
Binding sitei123 – 1231S-adenosyl-L-methionine By similarity
Active sitei146 – 1461 By similarity
Binding sitei146 – 1461S-adenosyl-L-methionine By similarity
Binding sitei150 – 1501Substrate By similarity
Binding sitei182 – 1821Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-119-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Tcr_0119
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000229207Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_0119.

Structurei

3D structure databases

ProteinModelPortaliQ31JF8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2224Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31JF8-1 [UniParc]FASTAAdd to Basket

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MTENTESPQS VATDIPEHKR RIKSFVLRQG RLSQAQQNAI DTMWPQYGLT    50
LEDKLLDFNT LFGREAPTII EIGFGMGNSL AAMAEAHPEN NYIGIEVHRP 100
GVGALLKLVA EKGLTNVRVF NEDAIEVLNR QIPKNSLSAV YLFFPDPWHK 150
TKHKKRRILQ AEFAEKIAQY LAPGGQFHMA TDWEDYALHM MSVMSAAKGY 200
RNISGEGQYT PRPDYRPLTK FEQRGHRLGH GVWDLVFERI 240
Length:240
Mass (Da):27,349
Last modified:December 6, 2005 - v1
Checksum:i2B61430A124B7CAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB40715.1.
RefSeqiYP_390389.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB40715; ABB40715; Tcr_0119.
GeneIDi3762527.
KEGGitcx:Tcr_0119.
PATRICi23972106. VBIThiCru83387_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB40715.1 .
RefSeqi YP_390389.1. NC_007520.2.

3D structure databases

ProteinModelPortali Q31JF8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_0119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB40715 ; ABB40715 ; Tcr_0119 .
GeneIDi 3762527.
KEGGi tcx:Tcr_0119.
PATRICi 23972106. VBIThiCru83387_0125.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci TCRU317025:GHE8-119-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiTRMB_THICR
AccessioniPrimary (citable) accession number: Q31JF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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