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Protein

Ribulose bisphosphate carboxylase

Gene

cbbM

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In contrast to form I RuBisCO, the form II RuBisCO are composed solely of large subunits.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111Substrate; in homodimeric partnerUniRule annotation1
Active sitei166Proton acceptorUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Metal bindingi191Magnesium; via carbamate groupUniRule annotation1
Metal bindingi193MagnesiumUniRule annotation1
Metal bindingi194MagnesiumUniRule annotation1
Active sitei287Proton acceptorUniRule annotation1
Binding sitei288SubstrateUniRule annotation1
Binding sitei321SubstrateUniRule annotation1
Sitei329Transition state stabilizerUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processCalvin cycle, Carbon dioxide fixation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-436-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:cbbMUniRule annotation
Ordered Locus Names:Tcr_0424
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514141 – 459Ribulose bisphosphate carboxylaseAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi317025.Tcr_0424

Structurei

3D structure databases

ProteinModelPortaliQ31IK3
SMRiQ31IK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type II subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1 Bacteria
COG1850 LUCA
HOGENOMiHOG000230831
KOiK01601
OrthoDBiPOG091H14UZ

Family and domain databases

CDDicd08211 RuBisCO_large_II, 1 hit
Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01339 RuBisCO_L_type2, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020871 RuBisCO_lsuII
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q31IK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNRYADL SLKEEDLIAG QNHILVAYTM EPAAGYGYLE VAAHIAAESS
60 70 80 90 100
TGTNVEVCTT DDFTKGVDAI VYDIDEANGI MKVAYPFDLF DRNGLDGKTM
110 120 130 140 150
IVSFLTLAIG NNQGMGDVKN LQMFDFWVPE TKLHLFDGPA VDITNMWKML
160 170 180 190 200
GRDKDNGGYI AGTIIKPKLG LRPEPFADAA YQFWLGGDFI KNDEPQGNQT
210 220 230 240 250
FCPMKKVIPL VADAMKRAQD ETGETKLFSA NITADDHHEM CYRADYILET
260 270 280 290 300
FGADAPQVAF LVDGYVGGPG MITTARRNYP SQYLHYHRAG HGAITSPSAK
310 320 330 340 350
RGYTAFVLAK ISRLQGASGI HVGTMGYGKM EGDASDKNIA YMIERDECQG
360 370 380 390 400
PAFYQKWNGM KPTTPIISGG MNALRLPGFF ENLGHGNVIN TSGGGSYGHI
410 420 430 440 450
DSPAAGATSL RQSYECWKSG ADPIEFAKDH KEFARAFESF PADADKIYPG

WREKLGVHK
Length:459
Mass (Da):50,281
Last modified:December 6, 2005 - v1
Checksum:iCA55D3D2306EA579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41020.1
RefSeqiWP_011369845.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB41020; ABB41020; Tcr_0424
KEGGitcx:Tcr_0424

Similar proteinsi

Entry informationi

Entry nameiRBL2_HYDCU
AccessioniPrimary (citable) accession number: Q31IK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health