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Protein

Ribulose bisphosphate carboxylase large chain 1

Gene

cbbL1

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115Substrate; in homodimeric partnerUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei167Proton acceptorUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Metal bindingi193Magnesium; via carbamate groupUniRule annotation1
Metal bindingi195MagnesiumUniRule annotation1
Metal bindingi196MagnesiumUniRule annotation1
Active sitei286Proton acceptorUniRule annotation1
Binding sitei287SubstrateUniRule annotation1
Binding sitei319SubstrateUniRule annotation1
Sitei326Transition state stabilizerUniRule annotation1
Binding sitei371SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processCalvin cycle, Carbon dioxide fixation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-439-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chain 1UniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunit 1UniRule annotation
Gene namesi
Name:cbbL1UniRule annotation
Ordered Locus Names:Tcr_0427
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514661 – 472Ribulose bisphosphate carboxylase large chain 1Add BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193N6-carboxylysineUniRule annotation1

Proteomic databases

PRIDEiQ31IK0

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi317025.Tcr_0427

Structurei

3D structure databases

ProteinModelPortaliQ31IK0
SMRiQ31IK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1 Bacteria
COG1850 LUCA
HOGENOMiHOG000230831
KOiK01601
OrthoDBiPOG091H14UZ

Family and domain databases

Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01338 RuBisCO_L_type1, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR020878 RuBisCo_large_chain_AS
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020888 RuBisCO_lsuI
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit
PROSITEiView protein in PROSITE
PS00157 RUBISCO_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q31IK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTYNAGVK EYRETYWMPE YEPKDSDFLA CFKVIPQDGV PREEIAAAVA
60 70 80 90 100
AESSTGTWTT VWTDLLTDLD YYKGRAYKIE DVPGDDAAFY AFIAYPIDLF
110 120 130 140 150
EEGSVVSVMT SLVGNVFGFK ALRACRLEDI RFPLAYVMTC GGPPHGIQVE
160 170 180 190 200
RDKMDKYGRP MLGCTIKPKL GLSAKNYGRA VYECLRGGLD FTKDDENVTS
210 220 230 240 250
QPFMRWRDRF LFCQDAIEKA QAETGERKGH YLNCTAGTPE EMYERAEFAK
260 270 280 290 300
EIGTPIIMHD YLTGGFTANT GLANYCRKNG LLLHIHRAMH GVIDRNPHHG
310 320 330 340 350
IHFRVLTKAL RLSGGDHLHS GTVVGKLEGD REATLGWIDL MRDSFIPEDR
360 370 380 390 400
SRGIMFDQDF GAMPGVMPVA SGGIHVWHMP ALVSIFGDDS VLQFGGGTLG
410 420 430 440 450
HPWGNAAGAA ANRVALEACV QARNEGKEVE KEGKEILTNA AKHSPELKIA
460 470
METWKEIKFE FDTVDKLDVK HK
Length:472
Mass (Da):52,568
Last modified:December 6, 2005 - v1
Checksum:i5E70D6B51D425EC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41023.1
RefSeqiWP_011369848.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB41023; ABB41023; Tcr_0427
KEGGitcx:Tcr_0427

Entry informationi

Entry nameiRBL1A_HYDCU
AccessioniPrimary (citable) accession number: Q31IK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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