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Q31II8 (PUR9_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Tcr_0439
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000057916

Sequences

Sequence LengthMass (Da)Tools
Q31II8 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 3BA4A377131036FE

FASTA52056,605
        10         20         30         40         50         60 
MKPVRRALIS VSDKNGILEF AKSLTAMDVV ILSTGGTYKV LSEAGLPVTE VSEYTGFPEM 

        70         80         90        100        110        120 
MDGRVKTLHP KIHGGLLGRR GTDDAVMAEH GIDPIDMVVV NLYPFEATVA KPDCSLEDAI 

       130        140        150        160        170        180 
ENIDIGGPTM LRSAAKNHKD VAVVTDPHDY ARILEEMESN DGQLSHATRF DLAIKTFEQT 

       190        200        210        220        230        240 
ARYDGAISNY FGTMFSDDKD DTFPRTYNTQ FVKKQSMRYG ENPHQSAAFY TERNPTEASI 

       250        260        270        280        290        300 
STAKQLQGKA LSFNNIADTD AALELVKTFE ETACVIVKHA NPCGVSIGEN VFESYDRAYK 

       310        320        330        340        350        360 
TDPTSAFGGI IAFNRALDQE TAQAIIDRQF VEVIIAPNVS EDAKNVIAAK QNVRLLVCGD 

       370        380        390        400        410        420 
LGIQEPAYDY KRVTGGLLVQ DRDLGSVTED ELKVVTKRAP SEKEMADLQF AWKVAKYVKS 

       430        440        450        460        470        480 
NAIVYVKDGM TIGVGAGQMS RVYSAKIAGI KAADEGLEVP GSVMASDAFF PFRDGIDAAA 

       490        500        510        520 
EAGITAVIHP GGSMRDQEVI DAADEHGIAM VFTGMRHFKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB41035.1.
RefSeqYP_390709.1. NC_007520.2.

3D structure databases

ProteinModelPortalQ31II8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_0439.

Proteomic databases

PRIDEQ31II8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB41035; ABB41035; Tcr_0439.
GeneID3761258.
KEGGtcx:Tcr_0439.
PATRIC23972770. VBIThiCru83387_0451.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-445-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_THICR
AccessionPrimary (citable) accession number: Q31II8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways