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Q31II8

- PUR9_THICR

UniProt

Q31II8 - PUR9_THICR

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-445-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Tcr_0439
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Bifunctional purine biosynthesis protein PurHPRO_1000057916Add
BLAST

Proteomic databases

PRIDEiQ31II8.

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_0439.

Structurei

3D structure databases

ProteinModelPortaliQ31II8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q31II8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPVRRALIS VSDKNGILEF AKSLTAMDVV ILSTGGTYKV LSEAGLPVTE
60 70 80 90 100
VSEYTGFPEM MDGRVKTLHP KIHGGLLGRR GTDDAVMAEH GIDPIDMVVV
110 120 130 140 150
NLYPFEATVA KPDCSLEDAI ENIDIGGPTM LRSAAKNHKD VAVVTDPHDY
160 170 180 190 200
ARILEEMESN DGQLSHATRF DLAIKTFEQT ARYDGAISNY FGTMFSDDKD
210 220 230 240 250
DTFPRTYNTQ FVKKQSMRYG ENPHQSAAFY TERNPTEASI STAKQLQGKA
260 270 280 290 300
LSFNNIADTD AALELVKTFE ETACVIVKHA NPCGVSIGEN VFESYDRAYK
310 320 330 340 350
TDPTSAFGGI IAFNRALDQE TAQAIIDRQF VEVIIAPNVS EDAKNVIAAK
360 370 380 390 400
QNVRLLVCGD LGIQEPAYDY KRVTGGLLVQ DRDLGSVTED ELKVVTKRAP
410 420 430 440 450
SEKEMADLQF AWKVAKYVKS NAIVYVKDGM TIGVGAGQMS RVYSAKIAGI
460 470 480 490 500
KAADEGLEVP GSVMASDAFF PFRDGIDAAA EAGITAVIHP GGSMRDQEVI
510 520
DAADEHGIAM VFTGMRHFKH
Length:520
Mass (Da):56,605
Last modified:December 6, 2005 - v1
Checksum:i3BA4A377131036FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41035.1.
RefSeqiYP_390709.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB41035; ABB41035; Tcr_0439.
GeneIDi3761258.
KEGGitcx:Tcr_0439.
PATRICi23972770. VBIThiCru83387_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41035.1 .
RefSeqi YP_390709.1. NC_007520.2.

3D structure databases

ProteinModelPortali Q31II8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_0439.

Proteomic databases

PRIDEi Q31II8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB41035 ; ABB41035 ; Tcr_0439 .
GeneIDi 3761258.
KEGGi tcx:Tcr_0439.
PATRICi 23972770. VBIThiCru83387_0451.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci TCRU317025:GHE8-445-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiPUR9_THICR
AccessioniPrimary (citable) accession number: Q31II8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3