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Q31IE8

- SYL_THICR

UniProt

Q31IE8 - SYL_THICR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei637 – 6371ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTCRU317025:GHE8-485-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tcr_0479
    OrganismiThiomicrospira crunogena (strain XCL-2)
    Taxonomic identifieri317025 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
    ProteomesiUP000002713: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 877877Leucine--tRNA ligasePRO_0000334835Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi317025.Tcr_0479.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31IE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi50 – 6011"HIGH" regionAdd
    BLAST
    Motifi634 – 6385"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q31IE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTESMPEST NDYQPQSIEA AIQHVWDEQQ VFVAKEDDSK EKFYCLSMFP    50
    YPSGKLHMGH VRNYTIGDVV SRFQRMQGKN VLQPMGWDAF GLPAENAAMD 100
    NQVAPAKWTY QNIDYMRNQL KRLGLGYDWT REVATCHPEY YRWEQWLFTR 150
    LMEKGLVYRK LSVVNWDPVD QTVLANEQVI DGKGWRSGVP VERKEIAQWF 200
    LRITDYAEEL LTDLDQLEGW PEQVKTMQKN WIGKSTGLEI EFPIASGLDE 250
    SNGSLKVYTT RPDTLMGVTY VAVAADHPWA RKASVNNEPL ERFIEECSHI 300
    STAEADMETM EKKGVDTGIR VKHPITGDEV PVWAANFVLM GYGTGAVMSV 350
    PAHDQRDYEF AKAYDLPIKA VIAPKAGEEA DVSEAAFTEK GVLVNSGQFD 400
    GLKSKQALHE MAKVLGELGL GEKQTNYRLR DWGISRQRYW GCPIPVIYCP 450
    ACGALPVPEK DLPVRLPEDV VPDGSGSPLA KLDSFKKCEC PQCGGPANRE 500
    TDTFDTFFES SWYHARYTSR HEDNAMLDKA AADHWLPVDQ YIGGIEHAIL 550
    HLLYARFFHK LMRDEGLVSS DEPFKNLLTQ GMVLAGSWFT QDEKGKQTWY 600
    SPLDVDPVTD DKGAIVKGTL KSDGTEVQYG GIIKMSKSKN NGIDPQTLID 650
    QYGADTLRLY IMFASPPEQT LEWSDSAVEG AHRFLNRVWR QVQTHVSTGV 700
    VAACTSNDDL TKEQKALRLK LHTTLQKVTD DMGRRMHFNT AIAATMELLN 750
    DISRFKDESD AGRSVMQEAL EMLVLMLSPM TPHASQALWE ALGHDGLVLN 800
    VTWPTVDDAA LVKDEIEIMV QVNGKLRGKI EVAAEADKDT ILAAAKANEQ 850
    AAKFIDGKDI VKEIVVPGRL VNIVVKG 877
    Length:877
    Mass (Da):98,347
    Last modified:December 6, 2005 - v1
    Checksum:i8721947CB36B912F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41075.1.
    RefSeqiWP_011369900.1. NC_007520.2.
    YP_390749.1. NC_007520.2.

    Genome annotation databases

    EnsemblBacteriaiABB41075; ABB41075; Tcr_0479.
    GeneIDi3761580.
    KEGGitcx:Tcr_0479.
    PATRICi23972850. VBIThiCru83387_0491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41075.1 .
    RefSeqi WP_011369900.1. NC_007520.2.
    YP_390749.1. NC_007520.2.

    3D structure databases

    ProteinModelPortali Q31IE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317025.Tcr_0479.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB41075 ; ABB41075 ; Tcr_0479 .
    GeneIDi 3761580.
    KEGGi tcx:Tcr_0479.
    PATRICi 23972850. VBIThiCru83387_0491.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TCRU317025:GHE8-485-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: XCL-2.

    Entry informationi

    Entry nameiSYL_THICR
    AccessioniPrimary (citable) accession number: Q31IE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3