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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei637ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Tcr_0479
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348351 – 877Leucine--tRNA ligaseAdd BLAST877

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_0479

Structurei

3D structure databases

ProteinModelPortaliQ31IE8
SMRiQ31IE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 60"HIGH" regionAdd BLAST11
Motifi634 – 638"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q31IE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTESMPEST NDYQPQSIEA AIQHVWDEQQ VFVAKEDDSK EKFYCLSMFP
60 70 80 90 100
YPSGKLHMGH VRNYTIGDVV SRFQRMQGKN VLQPMGWDAF GLPAENAAMD
110 120 130 140 150
NQVAPAKWTY QNIDYMRNQL KRLGLGYDWT REVATCHPEY YRWEQWLFTR
160 170 180 190 200
LMEKGLVYRK LSVVNWDPVD QTVLANEQVI DGKGWRSGVP VERKEIAQWF
210 220 230 240 250
LRITDYAEEL LTDLDQLEGW PEQVKTMQKN WIGKSTGLEI EFPIASGLDE
260 270 280 290 300
SNGSLKVYTT RPDTLMGVTY VAVAADHPWA RKASVNNEPL ERFIEECSHI
310 320 330 340 350
STAEADMETM EKKGVDTGIR VKHPITGDEV PVWAANFVLM GYGTGAVMSV
360 370 380 390 400
PAHDQRDYEF AKAYDLPIKA VIAPKAGEEA DVSEAAFTEK GVLVNSGQFD
410 420 430 440 450
GLKSKQALHE MAKVLGELGL GEKQTNYRLR DWGISRQRYW GCPIPVIYCP
460 470 480 490 500
ACGALPVPEK DLPVRLPEDV VPDGSGSPLA KLDSFKKCEC PQCGGPANRE
510 520 530 540 550
TDTFDTFFES SWYHARYTSR HEDNAMLDKA AADHWLPVDQ YIGGIEHAIL
560 570 580 590 600
HLLYARFFHK LMRDEGLVSS DEPFKNLLTQ GMVLAGSWFT QDEKGKQTWY
610 620 630 640 650
SPLDVDPVTD DKGAIVKGTL KSDGTEVQYG GIIKMSKSKN NGIDPQTLID
660 670 680 690 700
QYGADTLRLY IMFASPPEQT LEWSDSAVEG AHRFLNRVWR QVQTHVSTGV
710 720 730 740 750
VAACTSNDDL TKEQKALRLK LHTTLQKVTD DMGRRMHFNT AIAATMELLN
760 770 780 790 800
DISRFKDESD AGRSVMQEAL EMLVLMLSPM TPHASQALWE ALGHDGLVLN
810 820 830 840 850
VTWPTVDDAA LVKDEIEIMV QVNGKLRGKI EVAAEADKDT ILAAAKANEQ
860 870
AAKFIDGKDI VKEIVVPGRL VNIVVKG
Length:877
Mass (Da):98,347
Last modified:December 6, 2005 - v1
Checksum:i8721947CB36B912F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41075.1

Genome annotation databases

EnsemblBacteriaiABB41075; ABB41075; Tcr_0479
KEGGitcx:Tcr_0479

Similar proteinsi

Entry informationi

Entry nameiSYL_HYDCU
AccessioniPrimary (citable) accession number: Q31IE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health