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Q31I42 (DDL_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Tcr_0585
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341190

Regions

Domain114 – 309196ATP-grasp
Nucleotide binding142 – 19554ATP By similarity

Sites

Metal binding2631Magnesium or manganese 1 By similarity
Metal binding2761Magnesium or manganese 1 By similarity
Metal binding2761Magnesium or manganese 2 By similarity
Metal binding2781Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31I42 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 6DEAA4BE8DA04B24

FASTA31334,269
        10         20         30         40         50         60 
MTQSSNQTKD RVQRLGKVAV LMGGVAAERD VSLRSGAEVL KALKSEGVDA VGCDVTSVAQ 

        70         80         90        100        110        120 
LVEIAQKYDR AFIALHGRWG EDGGVQAVLD SLALPYTGSG MTASALAMDK LRTKWLWKGV 

       130        140        150        160        170        180 
GLPTPAFIVV SPSRPLDVET FDLTFPVIVK PSHEGSSIGM RKVDTLDALQ EAVDFAQQYD 

       190        200        210        220        230        240 
SEILIEQWIT GREFTCAVLD GEALPMIQLK TDHDFYDFDA KYQSNTTEYL CPCGLEIAEE 

       250        260        270        280        290        300 
KRIQALVLQA FDAVGARHWG RVDLMLDDQN QPWLIEINTV PGMTDHSLVP MAAKAVDLSF 

       310 
SKLVLKLISL TLP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB41181.1.
RefSeqYP_390855.1. NC_007520.2.

3D structure databases

ProteinModelPortalQ31I42.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_0585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB41181; ABB41181; Tcr_0585.
GeneID3762410.
KEGGtcx:Tcr_0585.
PATRIC23973074. VBIThiCru83387_0601.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-595-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_THICR
AccessionPrimary (citable) accession number: Q31I42
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways