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Protein

Ribulose bisphosphate carboxylase large chain 2

Gene

cbbL2

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116Substrate; in homodimeric partnerUniRule annotation1
Binding sitei166SubstrateUniRule annotation1
Active sitei168Proton acceptorUniRule annotation1
Binding sitei170SubstrateUniRule annotation1
Metal bindingi194Magnesium; via carbamate groupUniRule annotation1
Metal bindingi196MagnesiumUniRule annotation1
Metal bindingi197MagnesiumUniRule annotation1
Active sitei287Proton acceptorUniRule annotation1
Binding sitei288SubstrateUniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Sitei327Transition state stabilizerUniRule annotation1
Binding sitei372SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processCalvin cycle, Carbon dioxide fixation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-883-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chain 2UniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunit 2UniRule annotation
Gene namesi
Name:cbbL2UniRule annotation
Ordered Locus Names:Tcr_0838
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514671 – 471Ribulose bisphosphate carboxylase large chain 2Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194N6-carboxylysineUniRule annotation1

Proteomic databases

PRIDEiQ31HD9

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi317025.Tcr_0838

Structurei

3D structure databases

ProteinModelPortaliQ31HD9
SMRiQ31HD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1 Bacteria
COG1850 LUCA
HOGENOMiHOG000230831
KOiK01601
OrthoDBiPOG091H14UZ

Family and domain databases

Gene3Di3.20.20.110, 1 hit
3.30.70.150, 1 hit
HAMAPiMF_01338 RuBisCO_L_type1, 1 hit
InterProiView protein in InterPro
IPR033966 RuBisCO
IPR000685 RuBisCO_lsu_C
IPR036376 RuBisCO_lsu_C_sf
IPR017443 RuBisCO_lsu_fd_N
IPR036422 RuBisCO_lsu_N_sf
IPR020888 RuBisCO_lsuI
PfamiView protein in Pfam
PF00016 RuBisCO_large, 1 hit
PF02788 RuBisCO_large_N, 1 hit
SFLDiSFLDS00014 RuBisCO, 1 hit
SUPFAMiSSF51649 SSF51649, 1 hit
SSF54966 SSF54966, 1 hit

Sequencei

Sequence statusi: Complete.

Q31HD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTFDAGV QDYQLTYWTP DYTPLDTDLL ACFKVVPQDG VPREEAAAAV
60 70 80 90 100
AAESSTGTWT TVWTDLLTDM EFYKGRCYRI EDVPGDKNAF YAFIAYPLDL
110 120 130 140 150
FEEGSVVNVL TSLVGNVFGF KAVRSLRLED LRFPIAFIKT CGGPPAGIQV
160 170 180 190 200
ERDKLNKYGR PMLGCTIKPK LGLSAKNYGR AVYECLRGGL DLTKDDENIN
210 220 230 240 250
SQPFQRWQNR FEFVADAVDK ATAETGERKG HYLNVTAGTV EEMMKRAEFA
260 270 280 290 300
KELGQPIIMH DFLTAGFTAN TTLANWCRDN GMLLHIHRAM HAVIDRNPNH
310 320 330 340 350
GIHFRVLAKC LRLSGGDHLH TGTVVGKLEG DRASTLGFVD QLREAFVPED
360 370 380 390 400
RSRGVFFDQD WGSMPGVMAV ASGGIHVWHM PALVNIFGDD SVLQFGGGTQ
410 420 430 440 450
GHPGGNAAGA AANRVALEAC VKARNEGRDL EREGGDILRD AARNSKELAV
460 470
ALDTWKEIKF EFDTVDKLDV G
Length:471
Mass (Da):51,865
Last modified:December 6, 2005 - v1
Checksum:i3568693BCFA7BBDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41434.1
RefSeqiWP_011370261.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB41434; ABB41434; Tcr_0838
KEGGitcx:Tcr_0838

Similar proteinsi

Entry informationi

Entry nameiRBL1B_HYDCU
AccessioniPrimary (citable) accession number: Q31HD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health