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Q31GY9

- HISX_THICR

UniProt

Q31GY9 - HISX_THICR

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331NADUniRule annotation
    Binding sitei194 – 1941NADUniRule annotation
    Binding sitei217 – 2171NADUniRule annotation
    Binding sitei240 – 2401SubstrateUniRule annotation
    Metal bindingi262 – 2621ZincUniRule annotation
    Binding sitei262 – 2621SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Active sitei330 – 3301Proton acceptorUniRule annotation
    Active sitei331 – 3311Proton acceptorUniRule annotation
    Binding sitei331 – 3311SubstrateUniRule annotation
    Metal bindingi364 – 3641ZincUniRule annotation
    Binding sitei364 – 3641SubstrateUniRule annotation
    Binding sitei418 – 4181SubstrateUniRule annotation
    Metal bindingi423 – 4231ZincUniRule annotation
    Binding sitei423 – 4231SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciTCRU317025:GHE8-1010-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:Tcr_0989
    OrganismiThiomicrospira crunogena (strain XCL-2)
    Taxonomic identifieri317025 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
    ProteomesiUP000002713: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Histidinol dehydrogenasePRO_0000229867Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi317025.Tcr_0989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31GY9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q31GY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNIRKLSAN ADGFKAELEA LLAWETVSND SVNEIVKDVL KNVRERGDEA    50
    LLEYTAKFDR LTLAKGSDLE IPKSELEAAL KRIPKDQRDG LELSAQRVKD 100
    YHEKQVMKSW SYTEDDGTFL GQQVTCLDRV GLYVPGGKAA YPSSVIMNAI 150
    PAKVAGVPEL IMVVPTPDGE VNDMVLAAAA ICGVDRVFTL GGAQAVAALA 200
    YGTETVPPVD KVVGPGNIFV ATAKREVFGT VGIDMIAGPS EILVYCDGKT 250
    NPDWIAMDLF SQAEHDEDAQ SILVTQDAEF AEKVYLSMNK LVKTLPREEI 300
    ITKAITDRGA IIVVDNEDQA IELINYIAPE HLELSIDEPK ALLPKIKHAG 350
    AIFMGRFTAE ALGDYCAGPN HVLPTSRTAR FSSPLGVYDF QKRSSLIMCS 400
    AEGANMLGQV AGVLADGEGL QAHAASARYR VKD 433
    Length:433
    Mass (Da):46,827
    Last modified:December 6, 2005 - v1
    Checksum:iFFD6A52F32331691
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41584.1.
    RefSeqiWP_011370411.1. NC_007520.2.
    YP_391258.1. NC_007520.2.

    Genome annotation databases

    EnsemblBacteriaiABB41584; ABB41584; Tcr_0989.
    GeneIDi3762167.
    KEGGitcx:Tcr_0989.
    PATRICi23973952. VBIThiCru83387_1031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41584.1 .
    RefSeqi WP_011370411.1. NC_007520.2.
    YP_391258.1. NC_007520.2.

    3D structure databases

    ProteinModelPortali Q31GY9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317025.Tcr_0989.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB41584 ; ABB41584 ; Tcr_0989 .
    GeneIDi 3762167.
    KEGGi tcx:Tcr_0989.
    PATRICi 23973952. VBIThiCru83387_1031.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci TCRU317025:GHE8-1010-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: XCL-2.

    Entry informationi

    Entry nameiHISX_THICR
    AccessioniPrimary (citable) accession number: Q31GY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3