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Q31GY9

- HISX_THICR

UniProt

Q31GY9 - HISX_THICR

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Protein
Histidinol dehydrogenase
Gene
hisD, Tcr_0989
Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NAD By similarity
Binding sitei194 – 1941NAD By similarity
Binding sitei217 – 2171NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei330 – 3301Proton acceptor By similarity
Active sitei331 – 3311Proton acceptor By similarity
Binding sitei331 – 3311Substrate By similarity
Metal bindingi364 – 3641Zinc By similarity
Binding sitei364 – 3641Substrate By similarity
Binding sitei418 – 4181Substrate By similarity
Metal bindingi423 – 4231Zinc By similarity
Binding sitei423 – 4231Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-1010-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Tcr_0989
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenaseUniRule annotation
PRO_0000229867Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_0989.

Structurei

3D structure databases

ProteinModelPortaliQ31GY9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31GY9-1 [UniParc]FASTAAdd to Basket

« Hide

MLNIRKLSAN ADGFKAELEA LLAWETVSND SVNEIVKDVL KNVRERGDEA    50
LLEYTAKFDR LTLAKGSDLE IPKSELEAAL KRIPKDQRDG LELSAQRVKD 100
YHEKQVMKSW SYTEDDGTFL GQQVTCLDRV GLYVPGGKAA YPSSVIMNAI 150
PAKVAGVPEL IMVVPTPDGE VNDMVLAAAA ICGVDRVFTL GGAQAVAALA 200
YGTETVPPVD KVVGPGNIFV ATAKREVFGT VGIDMIAGPS EILVYCDGKT 250
NPDWIAMDLF SQAEHDEDAQ SILVTQDAEF AEKVYLSMNK LVKTLPREEI 300
ITKAITDRGA IIVVDNEDQA IELINYIAPE HLELSIDEPK ALLPKIKHAG 350
AIFMGRFTAE ALGDYCAGPN HVLPTSRTAR FSSPLGVYDF QKRSSLIMCS 400
AEGANMLGQV AGVLADGEGL QAHAASARYR VKD 433
Length:433
Mass (Da):46,827
Last modified:December 6, 2005 - v1
Checksum:iFFD6A52F32331691
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41584.1.
RefSeqiWP_011370411.1. NC_007520.2.
YP_391258.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB41584; ABB41584; Tcr_0989.
GeneIDi3762167.
KEGGitcx:Tcr_0989.
PATRICi23973952. VBIThiCru83387_1031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41584.1 .
RefSeqi WP_011370411.1. NC_007520.2.
YP_391258.1. NC_007520.2.

3D structure databases

ProteinModelPortali Q31GY9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_0989.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB41584 ; ABB41584 ; Tcr_0989 .
GeneIDi 3762167.
KEGGi tcx:Tcr_0989.
PATRICi 23973952. VBIThiCru83387_1031.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci TCRU317025:GHE8-1010-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiHISX_THICR
AccessioniPrimary (citable) accession number: Q31GY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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