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Q31GT2

- PUR5_THICR

UniProt

Q31GT2 - PUR5_THICR

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, Tcr_1046
Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-1067-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Tcr_1046
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000258427Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1046.

Structurei

3D structure databases

ProteinModelPortaliQ31GT2.
SMRiQ31GT2. Positions 7-340.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q31GT2-1 [UniParc]FASTAAdd to Basket

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MTKNNQSISY KDAGVDIDAG NALVEAIKPI AKATARPEVS TSLGGFGALF    50
ELPMDKYKNP LLVSGTDGVG TKLRLAIESG KHDQVGIDLV AMCVNDLIVQ 100
GAEPLFFLDY YATGKLDIYT ARDVVAGIGE GCQQSGCALI GGETAEMPGM 150
YPDGDYDLAG FCVGIVEKAD LIDGTKVKAG DVLLGLASSG PHSNGYSLIR 200
KIIEVNGANL NEECDGQPLI DALMAPTRIY VKSILALMKQ IEIHAISHIT 250
GGGLLENLPR VMPNNTKAKV DTKSWNRPAV FDWIQTHGNV EFHEMHRTLN 300
CGIGMVVVVD EKDQQAAIDA LTAQGEVVSV IGKIESSESE TPEVDLV 347
Length:347
Mass (Da):36,929
Last modified:December 6, 2005 - v1
Checksum:i039086C76B62EA1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41641.1.
RefSeqiWP_011370468.1. NC_007520.2.
YP_391315.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB41641; ABB41641; Tcr_1046.
GeneIDi3760568.
KEGGitcx:Tcr_1046.
PATRICi23974070. VBIThiCru83387_1090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41641.1 .
RefSeqi WP_011370468.1. NC_007520.2.
YP_391315.1. NC_007520.2.

3D structure databases

ProteinModelPortali Q31GT2.
SMRi Q31GT2. Positions 7-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_1046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB41641 ; ABB41641 ; Tcr_1046 .
GeneIDi 3760568.
KEGGi tcx:Tcr_1046.
PATRICi 23974070. VBIThiCru83387_1090.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci TCRU317025:GHE8-1067-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiPUR5_THICR
AccessioniPrimary (citable) accession number: Q31GT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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