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Q31GT2

- PUR5_THICR

UniProt

Q31GT2 - PUR5_THICR

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTCRU317025:GHE8-1067-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:Tcr_1046
    OrganismiThiomicrospira crunogena (strain XCL-2)
    Taxonomic identifieri317025 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
    ProteomesiUP000002713: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258427Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi317025.Tcr_1046.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31GT2.
    SMRiQ31GT2. Positions 7-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q31GT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKNNQSISY KDAGVDIDAG NALVEAIKPI AKATARPEVS TSLGGFGALF    50
    ELPMDKYKNP LLVSGTDGVG TKLRLAIESG KHDQVGIDLV AMCVNDLIVQ 100
    GAEPLFFLDY YATGKLDIYT ARDVVAGIGE GCQQSGCALI GGETAEMPGM 150
    YPDGDYDLAG FCVGIVEKAD LIDGTKVKAG DVLLGLASSG PHSNGYSLIR 200
    KIIEVNGANL NEECDGQPLI DALMAPTRIY VKSILALMKQ IEIHAISHIT 250
    GGGLLENLPR VMPNNTKAKV DTKSWNRPAV FDWIQTHGNV EFHEMHRTLN 300
    CGIGMVVVVD EKDQQAAIDA LTAQGEVVSV IGKIESSESE TPEVDLV 347
    Length:347
    Mass (Da):36,929
    Last modified:December 6, 2005 - v1
    Checksum:i039086C76B62EA1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41641.1.
    RefSeqiWP_011370468.1. NC_007520.2.
    YP_391315.1. NC_007520.2.

    Genome annotation databases

    EnsemblBacteriaiABB41641; ABB41641; Tcr_1046.
    GeneIDi3760568.
    KEGGitcx:Tcr_1046.
    PATRICi23974070. VBIThiCru83387_1090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41641.1 .
    RefSeqi WP_011370468.1. NC_007520.2.
    YP_391315.1. NC_007520.2.

    3D structure databases

    ProteinModelPortali Q31GT2.
    SMRi Q31GT2. Positions 7-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317025.Tcr_1046.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB41641 ; ABB41641 ; Tcr_1046 .
    GeneIDi 3760568.
    KEGGi tcx:Tcr_1046.
    PATRICi 23974070. VBIThiCru83387_1090.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci TCRU317025:GHE8-1067-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: XCL-2.

    Entry informationi

    Entry nameiPUR5_THICR
    AccessioniPrimary (citable) accession number: Q31GT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3