Isocitrate dehydrogenase, NADP-dependent - Thiomicrospira crunogena (strain XCL-2)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, NADP-dependent EMBL ABB41696.1
EC=1.1.1.42 EMBL ABB41696.1

Gene names

Ordered Locus Names:

Tcr_1101

Organism

Thiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP] EMBL ABB41696.1

Taxonomic identifier

317025 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Piscirickettsiaceae › Thiomicrospira ›

Protein attributes

Sequence length	739 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL ABB41696.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Region

131 – 138

8

Substrate binding By similarity PIRSR PIRSR009407-2

Sites

Metal binding

349

1

Magnesium or manganese By similarity PIRSR PIRSR009407-3

Metal binding

547

1

Magnesium or manganese By similarity PIRSR PIRSR009407-3

Metal binding

551

1

Magnesium or manganese By similarity PIRSR PIRSR009407-3

Binding site

144

1

Substrate By similarity PIRSR PIRSR009407-2

Binding site

546

1

Substrate By similarity PIRSR PIRSR009407-2

Site

254

1

Critical for catalysis By similarity PIRSR PIRSR009407-1

Site

419

1

Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

Sequence

Length

Mass (Da)

Tools

Q31GM7 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: E52ED0373D36817D
Show »

FASTA

739

80,615

        10         20         30         40         50         60 
MTAKIIYTLT DEAPALATYS LLPIVEAFTK AAGVSVETRD ISLAGRILAN VPDKLSEAQK 

        70         80         90        100        110        120 
VGDALTELGN LAKTPEANII KLPNISASVP QLNAAIKELQ SQGYDIPDYP ATPQNAEEEK 

       130        140        150        160        170        180 
IKAAYAKVLG SAVNPVLREG NSDRRAPTSV KNFAKKHPHS MGAWSEDSKS KVAHMTEGDF 

       190        200        210        220        230        240 
YGSEKSMTLP EATEFKIEFV SESGDIKELK GTAPLQAGEV IDAAVMSQKA LRDFLAKAVA 

       250        260        270        280        290        300 
EAKEQGILFS IHLKATMMKV SDPIIFGQAV SVFFEDVFKK YADEFKKLGV NPNNGLGDVY 

       310        320        330        340        350        360 
SKIESLPADK QAEIEASIAK TIEDKADVAM VDSDKGITNL HVPSDVIVDA SMPAMIRTSG 

       370        380        390        400        410        420 
KMWNKDGQQQ DALAVIPDRC YAGVYQETIN FCKHHGAFDP TTMGTVPNVG LMAQKAEEYG 

       430        440        450        460        470        480 
SHDKTFQMDN AGTVRVVEPN GNVLLEQTVE AGDIFRMCQV KDAPIQDWVK LAVNRARATN 

       490        500        510        520        530        540 
TPAVFWLDTN RAHDHQLIEK VNHYLLDHDT TGLEIHIMSP EEATRFTLRH VKEGKDVISV 

       550        560        570        580        590        600 
TGNVLRDYLT DLFPILELGT SAKMLSIVPL MNGGGLFETG AGGSAPKHVQ QFMSENHLRW 

       610        620        630        640        650        660 
DSLGEFLALA VSLEHLATHF NNPKAQVLAD TLDKATGRFL ENNKSPSRKV GEIDNRGSHF 

       670        680        690        700        710        720 
YLAMYWAQEL AAQKADAELK ARFEKVADAL TQNEDTIMSE LNGSQGKSVD IGGYYKFNGE 

       730 
LASQAMRPSA TLNTLIDAV

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References

[1]

"The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2."
Scott K.M., Sievert S.M., Abril F.N., Ball L.A., Barrett C.J., Blake R.A., Boller A.J., Chain P.S.G., Clark J.A., Davis C.R., Detter C., Do K.F., Dobrinski K.P., Faza B.I., Fitzpatrick K.A., Freyermuth S.K., Harmer T.L., Hauser L.J.

Zeruth G.T.
PLoS Biol. 4:1-17(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: XCL-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000109 Genomic DNA. Translation: ABB41696.1.
RefSeq	YP_391370.1. NC_007520.2.
3D structure databases
ProteinModelPortal	Q31GM7.
SMR	Q31GM7. Positions 2-736.
ModBase	Search...
Protein-protein interaction databases
STRING	317025.Tcr_1101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB41696; ABB41696; Tcr_1101.
GeneID	3760713.
KEGG	tcx:Tcr_1101.
PATRIC	23974184. VBIThiCru83387_1147.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
OMA	FRMCQTK.
ProtClustDB	CLSK867411.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q31GM7_THICR

Accession

Primary (citable) accession number: Q31GM7

Entry history

Integrated into UniProtKB/TrEMBL:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information