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Q31GM7

- Q31GM7_THICR

UniProt

Q31GM7 - Q31GM7_THICR

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Tcr_1101

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei144 – 1441SubstrateUniRule annotation
    Sitei254 – 2541Critical for catalysis
    Metal bindingi349 – 3491Magnesium or manganeseUniRule annotation
    Sitei419 – 4191Critical for catalysisUniRule annotation
    Binding sitei546 – 5461SubstrateUniRule annotation
    Metal bindingi547 – 5471Magnesium or manganeseUniRule annotation
    Metal bindingi551 – 5511Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciTCRU317025:GHE8-1122-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Tcr_1101Imported
    OrganismiThiomicrospira crunogena (strain XCL-2)Imported
    Taxonomic identifieri317025 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
    ProteomesiUP000002713: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi317025.Tcr_1101.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31GM7.
    SMRiQ31GM7. Positions 2-736.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 1388Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiARFDKIK.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q31GM7-1 [UniParc]FASTAAdd to Basket

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    MTAKIIYTLT DEAPALATYS LLPIVEAFTK AAGVSVETRD ISLAGRILAN    50
    VPDKLSEAQK VGDALTELGN LAKTPEANII KLPNISASVP QLNAAIKELQ 100
    SQGYDIPDYP ATPQNAEEEK IKAAYAKVLG SAVNPVLREG NSDRRAPTSV 150
    KNFAKKHPHS MGAWSEDSKS KVAHMTEGDF YGSEKSMTLP EATEFKIEFV 200
    SESGDIKELK GTAPLQAGEV IDAAVMSQKA LRDFLAKAVA EAKEQGILFS 250
    IHLKATMMKV SDPIIFGQAV SVFFEDVFKK YADEFKKLGV NPNNGLGDVY 300
    SKIESLPADK QAEIEASIAK TIEDKADVAM VDSDKGITNL HVPSDVIVDA 350
    SMPAMIRTSG KMWNKDGQQQ DALAVIPDRC YAGVYQETIN FCKHHGAFDP 400
    TTMGTVPNVG LMAQKAEEYG SHDKTFQMDN AGTVRVVEPN GNVLLEQTVE 450
    AGDIFRMCQV KDAPIQDWVK LAVNRARATN TPAVFWLDTN RAHDHQLIEK 500
    VNHYLLDHDT TGLEIHIMSP EEATRFTLRH VKEGKDVISV TGNVLRDYLT 550
    DLFPILELGT SAKMLSIVPL MNGGGLFETG AGGSAPKHVQ QFMSENHLRW 600
    DSLGEFLALA VSLEHLATHF NNPKAQVLAD TLDKATGRFL ENNKSPSRKV 650
    GEIDNRGSHF YLAMYWAQEL AAQKADAELK ARFEKVADAL TQNEDTIMSE 700
    LNGSQGKSVD IGGYYKFNGE LASQAMRPSA TLNTLIDAV 739
    Length:739
    Mass (Da):80,615
    Last modified:December 6, 2005 - v1
    Checksum:iE52ED0373D36817D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41696.1.
    RefSeqiWP_011370523.1. NC_007520.2.
    YP_391370.1. NC_007520.2.

    Genome annotation databases

    EnsemblBacteriaiABB41696; ABB41696; Tcr_1101.
    GeneIDi3760713.
    KEGGitcx:Tcr_1101.
    PATRICi23974184. VBIThiCru83387_1147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41696.1 .
    RefSeqi WP_011370523.1. NC_007520.2.
    YP_391370.1. NC_007520.2.

    3D structure databases

    ProteinModelPortali Q31GM7.
    SMRi Q31GM7. Positions 2-736.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317025.Tcr_1101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB41696 ; ABB41696 ; Tcr_1101 .
    GeneIDi 3760713.
    KEGGi tcx:Tcr_1101.
    PATRICi 23974184. VBIThiCru83387_1147.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi ARFDKIK.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci TCRU317025:GHE8-1122-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: XCL-2Imported.

    Entry informationi

    Entry nameiQ31GM7_THICR
    AccessioniPrimary (citable) accession number: Q31GM7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3