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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44S-adenosyl-L-methionineUniRule annotation1
Binding sitei63S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei84S-adenosyl-L-methionineUniRule annotation1
Binding sitei128S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-1250-MONOMER
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:Tcr_1190
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002417421 – 241Ubiquinone biosynthesis O-methyltransferaseAdd BLAST241

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1190

Structurei

3D structure databases

ProteinModelPortaliQ31GD8
SMRiQ31GD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFD Bacteria
COG2227 LUCA
HOGENOMiHOG000278065
KOiK00568
OrthoDBiPOG091H064Z

Family and domain databases

HAMAPiMF_00472 UbiG, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR010233 UbiG_MeTrfase
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01983 UbiG, 1 hit

Sequencei

Sequence statusi: Complete.

Q31GD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQADLNKHK NADPSELNNF NQLANTWWDE SGEFGALHKI NPLRIEFIKQ
60 70 80 90 100
FQSIENKTIL DVGCGGGILS ESLAKAGGNV TGIDLAEDVL TIARLHSLDT
110 120 130 140 150
ETKVNYHLIS AEDHAQTHEE EYDIVTCMEM LEHVPDPASI IHAAAKAVKP
160 170 180 190 200
GGWVFFSTLN RNYKSYLLAI FAAEQVLNLV PKGTHTHDKF IQPSELDAMA
210 220 230 240
RQAGLFLKEG AGIDFNPLLK RYRLTDRLDV NYLLAYQKSA V
Length:241
Mass (Da):26,834
Last modified:December 6, 2005 - v1
Checksum:iCB6E6CC1B9C4F56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41785.1
RefSeqiWP_011370613.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB41785; ABB41785; Tcr_1190
KEGGitcx:Tcr_1190

Similar proteinsi

Entry informationi

Entry nameiUBIG_HYDCU
AccessioniPrimary (citable) accession number: Q31GD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health