Reviewed, UniProtKB/Swiss-Prot Q31GD4 (HIS82_THICR)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 2
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 2

Gene names

Name:	hisC2
Ordered Locus Names:	Tcr_1194

Organism

Thiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]

Taxonomic identifier

317025 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Piscirickettsiaceae › Thiomicrospira

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Histidinol-phosphate aminotransferase 2 HAMAP MF_01023		PRO_0000230226
Amino acid modifications
	Modified residue	229	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q31GD4-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: CF7F7E08A5086721	FASTA	373	41,389
	10 20 30 40 50 60 MSQSLFCDEV LPHISDIQVY QPGKPISEVQ REHNLLRISK LASNENPLGA SPKAIKAVQS 70 80 90 100 110 120 ELINMGRYPD GNSFYLKQDL ADFLQKQPTE IALGNGSNEL LELVARIFAG KGDEIIYSQY 130 140 150 160 170 180 AFAVYSISTQ AVGATGIEVP AKEWGHDLEA MAEAITDKTK LIYLANPNNP TGTLFTQKEW 190 200 210 220 230 240 EAFISKVPSN VIVVLDEAYT EYVTHDEYAN GLNYLEQYPN LIVSRTFSKA YGLAALRIGY 250 260 270 280 290 300 MVANEELIAY INRLRAPFNI NHLAQVAAKA ALKDPMFVKK TVDLNTQGMQ TLTQFFEEKG 310 320 330 340 350 360 LSYIPSQGNF VCVDLGPDSL KINQALLKEG VIVRPVAPEG KFSEFLRISI GLPNENQHFM 370 AALNKILTSS NFK

References

[1]

"The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2." Scott K.M., Sievert S.M., Abril F.N., Ball L.A., Barrett C.J., Blake R.A., Boller A.J., Chain P.S.G., Clark J.A., Davis C.R., Detter C., Do K.F., Dobrinski K.P., Faza B.I., Fitzpatrick K.A., Freyermuth S.K., Harmer T.L., Hauser L.J. , Huegler M., Kerfeld C.A., Klotz M.G., Kong W.W., Land M., Lapidus A., Larimer F.W., Longo D.L., Lucas S., Malfatti S.A., Massey S.E., Martin D.D., McCuddin Z., Meyer F., Moore J.L., Ocampo L.H. Jr., Paul J.H., Paulsen I.T., Reep D.K., Ren Q., Ross R.L., Sato P.Y., Thomas P., Tinkham L.E., Zeruth G.T. PLoS Biol. 4:1-17(2006) [PubMed: 17105352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000109 Genomic DNA. Translation: ABB41789.1.
RefSeq	YP_391463.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q31GD4.
Genome annotation databases
GeneID	3760612.
GenomeReviews	Gene locus Tcr_1194 in contig CP000109_GR.
KEGG	tcx:Tcr_1194.
NMPDR	fig|317025.3.peg.674.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q31GD4.
OMA	VANEELI.
Enzyme and pathway databases
BioCyc	TCRU317025:TCR_1194-MON.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS82_THICR

Accession

Primary (citable) accession number: Q31GD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	December 6, 2005
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)