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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16SubstrateUniRule annotation1
Binding sitei38SubstrateUniRule annotation1
Active sitei67Proton donorUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei185SubstrateUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei214Substrate; via amide nitrogenUniRule annotation1
Binding sitei215SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-1261-MONOMER
UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Tcr_1201
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419261 – 236Orotidine 5'-phosphate decarboxylaseAdd BLAST236

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi317025.Tcr_1201

Structurei

3D structure databases

ProteinModelPortaliQ31GC7
SMRiQ31GC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 74Substrate bindingUniRule annotation10

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106EG9 Bacteria
COG0284 LUCA
HOGENOMiHOG000226070
KOiK01591
OrthoDBiPOG091H0256

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_B OMPdecase_type1_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q31GC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSVQPDPK VVVALDFPKT QLAEDFARHL DPQLCRLKVG KELFALGGPQ
60 70 80 90 100
LVEKLITQGF EVFLDLKYHD IPNTVAMACR AAAEMGVWMV NVHSLGGRKM
110 120 130 140 150
MEAAKEAVLS ASHQPLLIGV TILTSMETED LAEIGLTGTP KENVLRLAKL
160 170 180 190 200
AHSSGLDGVV SSAQEASDLR KEIGQDFCLV TPGIRPANAD VNDQKRIMTP
210 220 230
ADAMAAGSSY LVVGRPITQA KDPIAVLNEI NASIGR
Length:236
Mass (Da):25,336
Last modified:December 6, 2005 - v1
Checksum:i178498D19FB6E419
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41796.1
RefSeqiWP_011370624.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB41796; ABB41796; Tcr_1201
KEGGitcx:Tcr_1201

Similar proteinsi

Entry informationi

Entry nameiPYRF_HYDCU
AccessioniPrimary (citable) accession number: Q31GC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health