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Q31G55

- LPXB_THICR

UniProt

Q31G55 - LPXB_THICR

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciTCRU317025:GHE8-1306-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Tcr_1273
    OrganismiThiomicrospira crunogena (strain XCL-2)
    Taxonomic identifieri317025 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
    ProteomesiUP000002713: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Lipid-A-disaccharide synthasePRO_0000255230Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi317025.Tcr_1273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31G55.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiNQNASEL.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q31G55-1 [UniParc]FASTAAdd to Basket

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    MVAGEASGDT LGADLILSLK KRFPNARFVG IGGQKMIANG FESWYPLEKL    50
    SVMGLFEVLK HLPSLLRLRK ELIQKLLQLK PDVFIGIDAP DFNFKMEGIL 100
    KENAIPTIHY VGPSVWAWRE KRLLKICKQV DGVLVLFPFE TAYYDKYGIP 150
    SKFVGHPLTN QVADSPDKHS ARQQLGLSSD TPVTGILPGS RSSEINLMID 200
    VYVQVATKLH EAYPQMKFVI PCVNQAAKER VALSISLYGK GIDFILLDQQ 250
    AQLAMAASDQ LIVTSGTATL EAALMQRPLI LAIKLHPISY WIMKRLATTK 300
    WVGLPNVLAG KCIVPELIQE NATVDKIAQT LDKLITDKEM REVQLTEFKK 350
    QYDALNQNAS ELAADAVVKW AKLKND 376
    Length:376
    Mass (Da):41,827
    Last modified:December 6, 2005 - v1
    Checksum:i063885AC96BB118E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41868.1.
    RefSeqiWP_011370696.1. NC_007520.2.
    YP_391542.1. NC_007520.2.

    Genome annotation databases

    EnsemblBacteriaiABB41868; ABB41868; Tcr_1273.
    GeneIDi3761662.
    KEGGitcx:Tcr_1273.
    PATRICi23974564. VBIThiCru83387_1326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000109 Genomic DNA. Translation: ABB41868.1 .
    RefSeqi WP_011370696.1. NC_007520.2.
    YP_391542.1. NC_007520.2.

    3D structure databases

    ProteinModelPortali Q31G55.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317025.Tcr_1273.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB41868 ; ABB41868 ; Tcr_1273 .
    GeneIDi 3761662.
    KEGGi tcx:Tcr_1273.
    PATRICi 23974564. VBIThiCru83387_1326.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi NQNASEL.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci TCRU317025:GHE8-1306-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: XCL-2.

    Entry informationi

    Entry nameiLPXB_THICR
    AccessioniPrimary (citable) accession number: Q31G55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3