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Q31G55 (LPXB_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Tcr_1273
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255230

Sequences

Sequence LengthMass (Da)Tools
Q31G55 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 063885AC96BB118E

FASTA37641,827
        10         20         30         40         50         60 
MVAGEASGDT LGADLILSLK KRFPNARFVG IGGQKMIANG FESWYPLEKL SVMGLFEVLK 

        70         80         90        100        110        120 
HLPSLLRLRK ELIQKLLQLK PDVFIGIDAP DFNFKMEGIL KENAIPTIHY VGPSVWAWRE 

       130        140        150        160        170        180 
KRLLKICKQV DGVLVLFPFE TAYYDKYGIP SKFVGHPLTN QVADSPDKHS ARQQLGLSSD 

       190        200        210        220        230        240 
TPVTGILPGS RSSEINLMID VYVQVATKLH EAYPQMKFVI PCVNQAAKER VALSISLYGK 

       250        260        270        280        290        300 
GIDFILLDQQ AQLAMAASDQ LIVTSGTATL EAALMQRPLI LAIKLHPISY WIMKRLATTK 

       310        320        330        340        350        360 
WVGLPNVLAG KCIVPELIQE NATVDKIAQT LDKLITDKEM REVQLTEFKK QYDALNQNAS 

       370 
ELAADAVVKW AKLKND 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB41868.1.
RefSeqYP_391542.1. NC_007520.2.

3D structure databases

ProteinModelPortalQ31G55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_1273.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB41868; ABB41868; Tcr_1273.
GeneID3761662.
KEGGtcx:Tcr_1273.
PATRIC23974564. VBIThiCru83387_1326.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMANQNASEL.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-1306-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_THICR
AccessionPrimary (citable) accession number: Q31G55
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways