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Q31G41

- GLND_THICR

UniProt

Q31G41 - GLND_THICR

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Protein
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Gene
glnD, Tcr_1287
Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism By similarity.UniRule annotation

Catalytic activityi

UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII].UniRule annotation
Uridylyl-[protein-PII] + H2O = UMP + [protein-PII].UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity By similarity.UniRule annotation

GO - Molecular functioni

  1. [protein-PII] uridylyltransferase activity Source: UniProtKB-HAMAP
  2. amino acid binding Source: InterPro
  3. metal ion binding Source: InterPro
  4. phosphoric diester hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. regulation of nitrogen utilization Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-1320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional uridylyltransferase/uridylyl-removing enzyme
Short name:
UTase/UR
Alternative name(s):
Bifunctional [protein-PII] modification enzyme
Bifunctional nitrogen sensor protein
Including the following 2 domains:
[Protein-PII] uridylyltransferase (EC:2.7.7.59)
Short name:
PII uridylyltransferase
Short name:
UTase
[Protein-PII]-UMP uridylyl-removing enzyme (EC:3.1.4.-)
Short name:
UR
Gene namesi
Name:glnD
Ordered Locus Names:Tcr_1287
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 888888Bifunctional uridylyltransferase/uridylyl-removing enzymeUniRule annotation
PRO_0000231696Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1287.

Structurei

3D structure databases

ProteinModelPortaliQ31G41.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini469 – 600132HD
Add
BLAST
Domaini710 – 78778ACT 1
Add
BLAST
Domaini817 – 88872ACT 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 348348UridylyltransferaseUniRule annotation
Add
BLAST
Regioni349 – 709361Uridylyl-removingUniRule annotation
Add
BLAST

Domaini

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the GlnD family.
Contains 2 ACT domains.
Contains 1 HD domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2844.
HOGENOMiHOG000261778.
KOiK00990.
OMAiHHLLMSV.
OrthoDBiEOG6CCH44.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
HAMAPiMF_00277. PII_uridylyl_transf.
InterProiIPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006288. PII_uridyltransf. 1 hit.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01693. UTase_glnD. 1 hit.
PROSITEiPS51671. ACT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31G41-1 [UniParc]FASTAAdd to Basket

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MATTTDKQVS PTSPSFVYNL DHEDRNTSLK SGRAVLTDFN EQQFVKFDKG    50
CSIETLLKER TSFIDQLLKK IWEHFFSKDE CEQLTLVAVG GYGRGELQPY 100
SDIDLLILGE NFIELQPKIV EFITYLWDIG FEVGHAVRNL EDCIEAGRED 150
VTTATNLLEA RWLAGNYEQF LSLQNLFNLK SFWPSHEFFQ AKLEEQEKRH 200
KRYNDTLYQL EPNIKESPGG LRDIQTILWV AKRHFGASSL QELMQHNFIS 250
LQEYKEIQAA YLYLNRIRFA LHRLKKRHED RLLFDHQQQL AELLNHDDRP 300
EHNDSIKAVE AFMKPYYQNA HIVARLNEIL LQHFKEEIYH FAEDKIEPIN 350
PRFRIINNYL DVVKENLFAK NPTALLEIFI IIENYQHLIQ GIRSRTIRLI 400
RNHLHLIDDQ FRSDPINKAL FIEIFRQPKG VNAAVKRMYA YGILGAYLPS 450
FKKITGLMQF NIFHAYTVDE HTILVIRNLR RFFIKQHAYE FPTAHQIATQ 500
LCKPEILLLA GLFHDIAKGR NGAHEKLGAV DAKAFSQKHN LNKNDTDLLS 550
WLVLRHLDFS YVAQKKDLSD PEIIQQFAEK VGTQQRLDYL YLLTLADVRS 600
TSDEVWNDWK NQLFLQLYHN TTQALDSSSS QPRDRVKQAI FNKEKASELL 650
KKRGLIPMHF QGFWQAFEQT DFFNRQSAAE IARITRVLFE EDHEAINIHL 700
QPTTSRGATE LIIYMHDRDY LFAQFTQIID KLDLNIVEAK IYSGEDDMTL 750
VIIYLLNRES TSITDPMILT EIEETLKHQL FLKDDTMPPT QPEPRRIRVF 800
EMPTHIQFQE INEELTELSI STKDIPGLLA KIGQAFKSCK IRVHDAKINT 850
VGEKAEDTFM ISSTTNESIH TRHSQEELKQ ALLNNIEQ 888
Length:888
Mass (Da):103,724
Last modified:December 6, 2005 - v1
Checksum:i842AEC6110A9F414
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41882.1.
RefSeqiYP_391556.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB41882; ABB41882; Tcr_1287.
GeneIDi3761676.
KEGGitcx:Tcr_1287.
PATRICi23974592. VBIThiCru83387_1340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41882.1 .
RefSeqi YP_391556.1. NC_007520.2.

3D structure databases

ProteinModelPortali Q31G41.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_1287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB41882 ; ABB41882 ; Tcr_1287 .
GeneIDi 3761676.
KEGGi tcx:Tcr_1287.
PATRICi 23974592. VBIThiCru83387_1340.

Phylogenomic databases

eggNOGi COG2844.
HOGENOMi HOG000261778.
KOi K00990.
OMAi HHLLMSV.
OrthoDBi EOG6CCH44.

Enzyme and pathway databases

BioCyci TCRU317025:GHE8-1320-MONOMER.

Family and domain databases

Gene3Di 1.10.3210.10. 1 hit.
HAMAPi MF_00277. PII_uridylyl_transf.
InterProi IPR002912. ACT_dom.
IPR010043. GlnD_Uridyltrans.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR002934. Nucleotidyltransferase.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF08335. GlnD_UR_UTase. 1 hit.
PF01966. HD. 1 hit.
PF01909. NTP_transf_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006288. PII_uridyltransf. 1 hit.
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01693. UTase_glnD. 1 hit.
PROSITEi PS51671. ACT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiGLND_THICR
AccessioniPrimary (citable) accession number: Q31G41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi