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Q31G32 (NAGZ_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:Tcr_1296
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000234927

Regions

Region176 – 1772Substrate binding By similarity

Sites

Active site1891Proton donor/acceptor By similarity
Active site2601Nucleophile By similarity
Binding site721Substrate By similarity
Binding site801Substrate By similarity
Binding site1461Substrate By similarity
Site1871Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31G32 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: A0D566B5B40E2756

FASTA35739,411
        10         20         30         40         50         60 
MEKLLGQAMP LGCIMVDLES TTLQPHEKER LLDPLVAGVI LFSRNYESIE QLQALTTEIH 

        70         80         90        100        110        120 
QLRHPKLLIA VDHEGGRVQR FKEGFSMLPA MGQLGKCFRA NEKEGLELAQ QVGWLMATEL 

       130        140        150        160        170        180 
LAVGVDFSFA PVVDLDYGDS RVIGDRAFDS DPVIVGKLGK ALVQGMRDAG MASVAKHFPG 

       190        200        210        220        230        240 
HGYIQADTHL EVAVDHREFQ EIAHKDIQPF LKLIENGLDA VMPAHVRYPK VDDLPAGFSK 

       250        260        270        280        290        300 
VWLQEVLRQQ CYFDGAIISD DMSMHAATEF GDAPTRVTAA LKAGCDLVLV CNDPVAADEV 

       310        320        330        340        350 
LSQVTWETGP LSHARLIRLH GKGHLKLSQL HNNPLWQSRA SHVSHFLNSV NQQGLLV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB41891.1.
RefSeqYP_391565.1. NC_007520.2.

3D structure databases

ProteinModelPortalQ31G32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_1296.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB41891; ABB41891; Tcr_1296.
GeneID3760678.
KEGGtcx:Tcr_1296.
PATRIC23974612. VBIThiCru83387_1350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMAADSHIAM.
OrthoDBEOG6BCT06.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-1329-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAGZ_THICR
AccessionPrimary (citable) accession number: Q31G32
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries