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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72SubstrateUniRule annotation1
Binding sitei80SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Sitei187Important for catalytic activityUniRule annotation1
Active sitei189Proton donor/acceptorUniRule annotation1
Active sitei260NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544

Protein family/group databases

CAZyiGH3 Glycoside Hydrolase Family 3

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:Tcr_1296
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002349271 – 357Beta-hexosaminidaseAdd BLAST357

Proteomic databases

PRIDEiQ31G32

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1296

Structurei

3D structure databases

ProteinModelPortaliQ31G32
SMRiQ31G32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 177Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA Bacteria
COG1472 LUCA
HOGENOMiHOG000248526
KOiK01207
OrthoDBiPOG091H039J

Family and domain databases

Gene3Di3.20.20.300, 1 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Q31G32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLGQAMP LGCIMVDLES TTLQPHEKER LLDPLVAGVI LFSRNYESIE
60 70 80 90 100
QLQALTTEIH QLRHPKLLIA VDHEGGRVQR FKEGFSMLPA MGQLGKCFRA
110 120 130 140 150
NEKEGLELAQ QVGWLMATEL LAVGVDFSFA PVVDLDYGDS RVIGDRAFDS
160 170 180 190 200
DPVIVGKLGK ALVQGMRDAG MASVAKHFPG HGYIQADTHL EVAVDHREFQ
210 220 230 240 250
EIAHKDIQPF LKLIENGLDA VMPAHVRYPK VDDLPAGFSK VWLQEVLRQQ
260 270 280 290 300
CYFDGAIISD DMSMHAATEF GDAPTRVTAA LKAGCDLVLV CNDPVAADEV
310 320 330 340 350
LSQVTWETGP LSHARLIRLH GKGHLKLSQL HNNPLWQSRA SHVSHFLNSV

NQQGLLV
Length:357
Mass (Da):39,411
Last modified:December 6, 2005 - v1
Checksum:iA0D566B5B40E2756
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41891.1

Genome annotation databases

EnsemblBacteriaiABB41891; ABB41891; Tcr_1296
KEGGitcx:Tcr_1296

Similar proteinsi

Entry informationi

Entry nameiNAGZ_HYDCU
AccessioniPrimary (citable) accession number: Q31G32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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