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Q31G32

- NAGZ_THICR

UniProt

Q31G32 - NAGZ_THICR

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Protein

Beta-hexosaminidase

Gene
nagZ, Tcr_1296
Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721Substrate By similarity
Binding sitei80 – 801Substrate By similarity
Binding sitei146 – 1461Substrate By similarity
Sitei187 – 1871Important for catalytic activity By similarity
Active sitei189 – 1891Proton donor/acceptor By similarity
Active sitei260 – 2601Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-1329-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:Tcr_1296
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Beta-hexosaminidaseUniRule annotationPRO_0000234927Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1296.

Structurei

3D structure databases

ProteinModelPortaliQ31G32.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1772Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiADSHIAM.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q31G32-1 [UniParc]FASTAAdd to Basket

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MEKLLGQAMP LGCIMVDLES TTLQPHEKER LLDPLVAGVI LFSRNYESIE    50
QLQALTTEIH QLRHPKLLIA VDHEGGRVQR FKEGFSMLPA MGQLGKCFRA 100
NEKEGLELAQ QVGWLMATEL LAVGVDFSFA PVVDLDYGDS RVIGDRAFDS 150
DPVIVGKLGK ALVQGMRDAG MASVAKHFPG HGYIQADTHL EVAVDHREFQ 200
EIAHKDIQPF LKLIENGLDA VMPAHVRYPK VDDLPAGFSK VWLQEVLRQQ 250
CYFDGAIISD DMSMHAATEF GDAPTRVTAA LKAGCDLVLV CNDPVAADEV 300
LSQVTWETGP LSHARLIRLH GKGHLKLSQL HNNPLWQSRA SHVSHFLNSV 350
NQQGLLV 357
Length:357
Mass (Da):39,411
Last modified:December 6, 2005 - v1
Checksum:iA0D566B5B40E2756
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41891.1.
RefSeqiWP_011370719.1. NC_007520.2.
YP_391565.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB41891; ABB41891; Tcr_1296.
GeneIDi3760678.
KEGGitcx:Tcr_1296.
PATRICi23974612. VBIThiCru83387_1350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB41891.1 .
RefSeqi WP_011370719.1. NC_007520.2.
YP_391565.1. NC_007520.2.

3D structure databases

ProteinModelPortali Q31G32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_1296.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB41891 ; ABB41891 ; Tcr_1296 .
GeneIDi 3760678.
KEGGi tcx:Tcr_1296.
PATRICi 23974612. VBIThiCru83387_1350.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi ADSHIAM.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci TCRU317025:GHE8-1329-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiNAGZ_THICR
AccessioniPrimary (citable) accession number: Q31G32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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