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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 380ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Tcr_1519
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
Proteomesi
  • UP000002713 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalUniRule annotationAdd BLAST21
Transmembranei61 – 81HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716621 – 581Lipid A export ATP-binding/permease protein MsbAAdd BLAST581

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi317025.Tcr_1519.

Structurei

3D structure databases

ProteinModelPortaliQ31FG2.
SMRiQ31FG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 307ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini339 – 574ABC transporterUniRule annotationAdd BLAST236

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q31FG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDRHTLSLY KRLLKYISGY KSAIFITLIT IAIIAATEPL SAIILGNLVD
60 70 80 90 100
ESLIEKDPNS FLLLPLQLAA VFIVKGVAEY FSKVMSTWIA QKAIFNIRSE
110 120 130 140 150
LYDKMLCLPQ AEHNQTSTGT LMSKVTYDVT QTGNALSEAW IVIARDSLTI
160 170 180 190 200
LALLATLIYY SWQLTLVMLI IGPIVAFFID RAGKLMRTSS TDMQDNMGEM
210 220 230 240 250
THRLEEGLKG YQDIKIYGSE KYELDRFKAS AESLRQNTMK VIKVSALNVP
260 270 280 290 300
LVQVIAAIAL SIVVYIAVQM VNAETMTAGN LITYVTAMGL IFEPIRRITN
310 320 330 340 350
INATVQRGMA AAKSIFAILD TPSEANNGKI ELSNVNGQID FNNVSFSYLG
360 370 380 390 400
TEKTALNNFS LSIPARKTTA LVGQSGSGKT TLANLITRFY QVNHGTITID
410 420 430 440 450
GIALDEIELN NLRANIAFVS QNVVLFNDTI AANIAYGHEE YDEQAIMNAA
460 470 480 490 500
KAAHAWEFIE KLPEGLNTII GDNGTLLSGG QRQRLAIARA FLKNAPILIM
510 520 530 540 550
DEATSALDNQ SEKLIQEAMN SLRKNRTVII IAHRLSTIEN ADKIVVLEEG
560 570 580
SLKEQGTHAE LMALNSIYSQ LYKQGNLSEQ V
Length:581
Mass (Da):64,038
Last modified:December 6, 2005 - v1
Checksum:i6FCA73CBD1D70EFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA. Translation: ABB42111.1.
RefSeqiWP_011370940.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB42111; ABB42111; Tcr_1519.
KEGGitcx:Tcr_1519.

Similar proteinsi

Entry informationi

Entry nameiMSBA_THICR
AccessioniPrimary (citable) accession number: Q31FG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 6, 2005
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families