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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-1912-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Tcr_1816
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei139 – 159HelicalUniRule annotationAdd BLAST21
Transmembranei175 – 195HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 228HelicalUniRule annotationAdd BLAST21
Transmembranei234 – 254HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502781 – 255Undecaprenyl-diphosphataseAdd BLAST255

Proteomic databases

PRIDEiQ31EL5

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1816

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q31EL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIFQAAILG IIEGLTEFLP ISSTGHLIVV SDWLGIEQTK QNTAFEVIIQ
60 70 80 90 100
VAAILAIFSH YKEKFSLQHL RLWNNVLIAF LPIAIIGFIF QDTVKAFFTI
110 120 130 140 150
ETVAWFFIIG GLIFLIMEKL YVDGKHRTQD IEDLTMRQAF WIGIIQVFAL
160 170 180 190 200
IPGTSRAGAS IVGGVMMGLD RKTAAEFSFL LALPVLMAAS GLDLLKHYED
210 220 230 240 250
FNNTSWTPLM VGFLMAFLAA WLTIKVFIKF LQTFTFNAFG VYRIVFGIVL

LIWFV
Length:255
Mass (Da):28,758
Last modified:December 6, 2005 - v1
Checksum:i7E81D805A75C418E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB42408.1
RefSeqiWP_011371237.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB42408; ABB42408; Tcr_1816
KEGGitcx:Tcr_1816

Similar proteinsi

Entry informationi

Entry nameiUPPP_HYDCU
AccessioniPrimary (citable) accession number: Q31EL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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