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Q31EF8

- GCH4_THICR

UniProt

Q31EF8 - GCH4_THICR

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thiomicrospira crunogena (strain XCL-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei150 – 1501May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciTCRU317025:GHE8-1925-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Tcr_1875
OrganismiThiomicrospira crunogena (strain XCL-2)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira
ProteomesiUP000002713: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311GTP cyclohydrolase FolE2PRO_0000289530Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1875.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31EF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDIACQPHQ DPQGKLNWVG MSGIELPIKI EQDSQTLTLS SQVQAYVSLD
60 70 80 90 100
DPLSKGIHMS RLYLILDEMG SNAPLNPASI QTLLTAFIES HQGLSQNAFV
110 120 130 140 150
EFRFDYYERR RSLKSDNSGW KHYPCTLRGE MRNGQFECEI SISVPYSSTC
160 170 180 190 200
PCSAALSRQL IQEAFEQQFN GQDLDYNQVL EWLGTPEGIC ATPHSQRSYA
210 220 230 240 250
QVKLKVNAEH PLNLSNVINQ IEDAVKTPVQ STVKREDEQE FARLNATNLM
260 270 280 290 300
FCEDAARRLQ AKLESCPEYK DYWVRVNHLE SLHPHDAVAI VTKNVPGGYS
310
DEPNFMERFQ N
Length:311
Mass (Da):35,302
Last modified:May 5, 2009 - v2
Checksum:iA943996682D67EA6
GO

Sequence cautioni

The sequence ABB42465.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB42465.1. Different initiation.
RefSeqiYP_392139.1. NC_007520.2.

Genome annotation databases

EnsemblBacteriaiABB42465; ABB42465; Tcr_1875.
GeneIDi3761088.
KEGGitcx:Tcr_1875.
PATRICi23975854. VBIThiCru83387_1955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000109 Genomic DNA. Translation: ABB42465.1 . Different initiation.
RefSeqi YP_392139.1. NC_007520.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317025.Tcr_1875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB42465 ; ABB42465 ; Tcr_1875 .
GeneIDi 3761088.
KEGGi tcx:Tcr_1875.
PATRICi 23975854. VBIThiCru83387_1955.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci TCRU317025:GHE8-1925-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: XCL-2.

Entry informationi

Entry nameiGCH4_THICR
AccessioniPrimary (citable) accession number: Q31EF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: October 1, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3