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Q31EF8 (GCH4_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Tcr_1875
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence ABB42465.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289530

Sites

Site1501May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31EF8 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: A943996682D67EA6

FASTA31135,302
        10         20         30         40         50         60 
MPDIACQPHQ DPQGKLNWVG MSGIELPIKI EQDSQTLTLS SQVQAYVSLD DPLSKGIHMS 

        70         80         90        100        110        120 
RLYLILDEMG SNAPLNPASI QTLLTAFIES HQGLSQNAFV EFRFDYYERR RSLKSDNSGW 

       130        140        150        160        170        180 
KHYPCTLRGE MRNGQFECEI SISVPYSSTC PCSAALSRQL IQEAFEQQFN GQDLDYNQVL 

       190        200        210        220        230        240 
EWLGTPEGIC ATPHSQRSYA QVKLKVNAEH PLNLSNVINQ IEDAVKTPVQ STVKREDEQE 

       250        260        270        280        290        300 
FARLNATNLM FCEDAARRLQ AKLESCPEYK DYWVRVNHLE SLHPHDAVAI VTKNVPGGYS 

       310 
DEPNFMERFQ N 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB42465.1. Different initiation.
RefSeqYP_392139.1. NC_007520.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_1875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB42465; ABB42465; Tcr_1875.
GeneID3761088.
KEGGtcx:Tcr_1875.
PATRIC23975854. VBIThiCru83387_1955.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-1925-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_THICR
AccessionPrimary (citable) accession number: Q31EF8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways