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Q31ED4 (ARGB_THICR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylglutamate kinase

EC=2.7.2.8
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK
Gene names
Name:argB
Ordered Locus Names:Tcr_1899
OrganismThiomicrospira crunogena (strain XCL-2) [Complete proteome] [HAMAP]
Taxonomic identifier317025 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeThiomicrospira

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP-Rule MF_00082

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP-Rule MF_00082

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00082.

Sequence similarities

Belongs to the acetylglutamate kinase family.

Sequence caution

The sequence ABB42489.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

proline biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetylglutamate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate 5-kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Acetylglutamate kinase HAMAP-Rule MF_00082
PRO_0000264781

Regions

Region68 – 692Substrate binding By similarity

Sites

Binding site901Substrate By similarity
Binding site1951Substrate By similarity
Site331Transition state stabilizer By similarity
Site2551Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31ED4 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: 51A7B4456EBAE057

FASTA29831,990
        10         20         30         40         50         60 
MNLNKAQAQN IASVLAEALP YIQRFSGKTI VVKYGGNAMT EEALKNGFAR DIVLMKLVGM 

        70         80         90        100        110        120 
NPVVVHGGGP QIGHLLERVG KQSEFIQGMR VTDSETMDIV EMVLGGMVNK EIVNLIHQHN 

       130        140        150        160        170        180 
GNAVGLTGKD GNLIRAKKME MTAFNEDLNA PELIDLGHVG EVERINTKVL DMLIQDDFIP 

       190        200        210        220        230        240 
VIAPVGVDEQ GHSYNINADL VAGKVAEALH AEKLMLLTNT PGLLDKQGEL LTGLNAESVA 

       250        260        270        280        290 
ALIEDGTIYG GMLPKIQCAL DAVQNGVESS HIIDGRVEHA VMLEVFTDEG VGTLITSH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000109 Genomic DNA. Translation: ABB42489.1. Different initiation.
RefSeqYP_392163.1. NC_007520.2.

3D structure databases

ProteinModelPortalQ31ED4.
SMRQ31ED4. Positions 3-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317025.Tcr_1899.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB42489; ABB42489; Tcr_1899.
GeneID3761093.
KEGGtcx:Tcr_1899.
PATRIC23975902. VBIThiCru83387_1979.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0548.
HOGENOMHOG000233259.
KOK00930.
OrthoDBEOG6T1WVF.
ProtClustDBPRK00942.

Enzyme and pathway databases

BioCycTCRU317025:GHE8-1949-MONOMER.
UniPathwayUPA00068; UER00107.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_00082_A. ArgB_A.
MF_00082_B. ArgB_B.
InterProIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000728. NAGK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SUPFAMSSF53633. SSF53633. 1 hit.
TIGRFAMsTIGR00761. argB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARGB_THICR
AccessionPrimary (citable) accession number: Q31ED4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways