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Q31DD8 (SPEA_PROM9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase
Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:PMT9312_0046
OrganismProchlorococcus marinus (strain MIT 9312) [Complete proteome] [HAMAP]
Taxonomic identifier74546 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP MF_01417

Cofactor

Magnesium By similarity. HAMAP MF_01417

Pyridoxal phosphate By similarity. HAMAP MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Biosynthetic arginine decarboxylase HAMAP MF_01417
PRO_1000024261

Regions

Region291 – 30111Substrate-binding Potential

Amino acid modifications

Modified residue1091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31DD8 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 7F89743E16C3B08A

FASTA64873,366
        10         20         30         40         50         60 
MTNFEPKKLK NIWTIEDSIS TYNIDKWGDK YFSINSKGNI SVTKDIKSEN KIDLFKLVKE 

        70         80         90        100        110        120 
LKSREINPPL IIRFNDILKD RINALHDSFF KAIKTYKYKN IYQGVFPVKC NQQKNVLEKI 

       130        140        150        160        170        180 
IEFGSQWNFG LEVGSKSELL IGLALLENQN SLLICNGYKD KKYIEIATLA RKLGKNPIIV 

       190        200        210        220        230        240 
IEQRDEVKRI IQAVQELNAT PLIGIRAKLS SKSSGRWGKS IGDNSKFGLS IPEIMLTIKE 

       250        260        270        280        290        300 
LKEANLINEM KLLHFHIGSQ ISDIAVIKDA LQEASQIYVE LCKLGAPMQY IDVGGGLGID 

       310        320        330        340        350        360 
FDGTKTSSNT STNYSLQNYA NDVIATIKDS CELNNIKHPI IISESGRAII SHCSVLIFNV 

       370        380        390        400        410        420 
LGTSHVSSKL QIFDKKNQQL IISNLLETFY ELKKLKNKKI NLSQIIELWN DAKKFKEDCL 

       430        440        450        460        470        480 
VAFRLGFLSL AERAYAEELT WACAKEISKN LNNDAINHPD LSEITETLAS TYYANLSIFK 

       490        500        510        520        530        540 
SIPDSWAINQ IFPIVPIHRH LEEPFCKGNF ADLTCDSDGK LNNFIDDGKI KSLLNLHKPE 

       550        560        570        580        590        600 
EDKDYLIGIF MTGAYQEALG NLHNLFGSTN VVHIDINQDN SYKVKNIIKE DSKSEILQLL 

       610        620        630        640 
DYSSASLVES IRINTESAID QKKLTIEEAR KLMDQIEISL RKSSYLSE

« Hide

References

[1]"Complete sequence of Prochlorococcus marinus str. MIT 9312."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9312.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000111 Genomic DNA. Translation: ABB49107.1.
RefSeqYP_396543.1. NC_007577.1.

3D structure databases

ProteinModelPortalQ31DD8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ31DD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3764827.
GenomeReviewsGene locus PMT9312_0046 in contig CP000111_GR.
KEGGpmi:PMT9312_0046.
PATRIC23003698. VBIProMar70153_0046.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHBG321436.
OMALICNGYK.
PhylomeDBQ31DD8.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycPMAR74546:PMT9312_0046-MONOMER.

Family and domain databases

HAMAPMF_01417. SpeA.
[Tree]
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 2 hits.
KOK01585.
PANTHERPTHR11482:SF3. Arg_decrbxlase. 1 hit.
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR01273. SpeA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_PROM9
AccessionPrimary (citable) accession number: Q31DD8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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