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Q31DB4

- DEF_PROM9

UniProt

Q31DB4 - DEF_PROM9

Protein

Peptide deformylase

Gene

def

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi121 – 1211IronUniRule annotation
    Metal bindingi163 – 1631IronUniRule annotation
    Active sitei164 – 1641UniRule annotation
    Metal bindingi167 – 1671IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciPMAR74546:GHRG-72-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:PMT9312_0070
    OrganismiProchlorococcus marinus (strain MIT 9312)
    Taxonomic identifieri74546 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002715: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Peptide deformylasePRO_0000301078Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi74546.PMT9312_0070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31DB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiEETGEEW.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q31DB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANHFSQLAK KSKTNGNSEK IAKEQTGKPS LEIYKLGDDV LRQNSKRITK    50
    VDESIRKLTR EMIQSMYAAK GIGLAAPQIG INKELLVIDV NFEDSAAEPL 100
    ILINPEITDY GTTLNSYEEG CLSIPGVYLN VVRPSTIKLK FRDEMGRPRK 150
    MKADGLLARC IQHEMDHLNG ILFVDRVTSK DDLKKELIKE GFHEKDVISI 200
    T 201
    Length:201
    Mass (Da):22,588
    Last modified:December 6, 2005 - v1
    Checksum:iBB0627C45E8A7F8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000111 Genomic DNA. Translation: ABB49131.1.
    RefSeqiWP_011375634.1. NC_007577.1.
    YP_396567.1. NC_007577.1.

    Genome annotation databases

    EnsemblBacteriaiABB49131; ABB49131; PMT9312_0070.
    GeneIDi3764853.
    KEGGipmi:PMT9312_0070.
    PATRICi23003750. VBIProMar70153_0071.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000111 Genomic DNA. Translation: ABB49131.1 .
    RefSeqi WP_011375634.1. NC_007577.1.
    YP_396567.1. NC_007577.1.

    3D structure databases

    ProteinModelPortali Q31DB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74546.PMT9312_0070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB49131 ; ABB49131 ; PMT9312_0070 .
    GeneIDi 3764853.
    KEGGi pmi:PMT9312_0070.
    PATRICi 23003750. VBIProMar70153_0071.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi EETGEEW.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci PMAR74546:GHRG-72-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9312.

    Entry informationi

    Entry nameiDEF_PROM9
    AccessioniPrimary (citable) accession number: Q31DB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3