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Q31CX3

- ENO_PROM9

UniProt

Q31CX3 - ENO_PROM9

Protein

Enolase

Gene

eno

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.UniRule annotation

    Catalytic activityi

    2-phospho-D-glycerate = phosphoenolpyruvate + H2O.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591SubstrateUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Active sitei209 – 2091Proton donorUniRule annotation
    Metal bindingi246 – 2461MagnesiumUniRule annotation
    Metal bindingi287 – 2871MagnesiumUniRule annotation
    Binding sitei287 – 2871SubstrateUniRule annotation
    Metal bindingi314 – 3141MagnesiumUniRule annotation
    Binding sitei314 – 3141SubstrateUniRule annotation
    Active sitei339 – 3391Proton acceptorUniRule annotation
    Binding sitei339 – 3391Substrate (covalent); in inhibited formUniRule annotation
    Binding sitei390 – 3901SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphopyruvate hydratase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciPMAR74546:GHRG-215-MONOMER.
    UniPathwayiUPA00109; UER00187.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EnolaseUniRule annotation (EC:4.2.1.11UniRule annotation)
    Alternative name(s):
    2-phospho-D-glycerate hydro-lyaseUniRule annotation
    2-phosphoglycerate dehydrataseUniRule annotation
    Gene namesi
    Name:enoUniRule annotation
    Ordered Locus Names:PMT9312_0210
    OrganismiProchlorococcus marinus (strain MIT 9312)
    Taxonomic identifieri74546 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002715: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation. Secreted UniRule annotation. Cell surface UniRule annotation
    Note: Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.UniRule annotation

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. phosphopyruvate hydratase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430EnolasePRO_0000267072Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi74546.PMT9312_0210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31CX3.
    SMRiQ31CX3. Positions 8-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni366 – 3694Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the enolase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0148.
    HOGENOMiHOG000072174.
    KOiK01689.
    OMAiRSEIKGQ.
    OrthoDBiEOG65J589.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPiMF_00318. Enolase.
    InterProiIPR000941. Enolase.
    IPR020810. Enolase_C.
    IPR029065. Enolase_C-like.
    IPR020809. Enolase_CS.
    IPR020811. Enolase_N.
    IPR029017. Enolase_N_like.
    [Graphical view]
    PANTHERiPTHR11902. PTHR11902. 1 hit.
    PfamiPF00113. Enolase_C. 1 hit.
    PF03952. Enolase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001400. Enolase. 1 hit.
    PRINTSiPR00148. ENOLASE.
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsiTIGR01060. eno. 1 hit.
    PROSITEiPS00164. ENOLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q31CX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKETIDFLID TIEARQVLDS RGNPTVEAEV FLECGASGRA IVPSGASTGA    50
    HEAHELRDGG SKYMGKGVLN AVNKIHETIS PALCGLSALD QTTVDKLMIE 100
    IDGTFNKSNL GANSILAVSL ATARASANAL DVPLYRYLGD PLSNLLPVPL 150
    MNVINGGAHA PNSLDFQEFM LVPHGVQNFS ESLRMGTEIF HSLKSLLDKK 200
    GLSTAVGDEG GFAPNLSSSE EAGDLLLEAI QKAGFIPGEQ VSLALDAAST 250
    EFYSDGIYKY EGKSLNSSEM ISYLSRLVSN YPIVSIEDGL AEDDWEGWSE 300
    LNKELGNKVQ LVGDDLFVTN TERLRKGIME KSANSILIKV NQIGTLTETL 350
    EAIELAKTSG FTSVISHRSG ETEDTTIADL SVATRSGQIK TGSLSRSERI 400
    AKYNRLLKIE EELGNQARFA GALGLGPKNI 430
    Length:430
    Mass (Da):46,071
    Last modified:December 6, 2005 - v1
    Checksum:iD263A14A2578F717
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000111 Genomic DNA. Translation: ABB49272.1.
    RefSeqiYP_396708.1. NC_007577.1.

    Genome annotation databases

    EnsemblBacteriaiABB49272; ABB49272; PMT9312_0210.
    GeneIDi3764995.
    KEGGipmi:PMT9312_0210.
    PATRICi23004038. VBIProMar70153_0214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000111 Genomic DNA. Translation: ABB49272.1 .
    RefSeqi YP_396708.1. NC_007577.1.

    3D structure databases

    ProteinModelPortali Q31CX3.
    SMRi Q31CX3. Positions 8-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 74546.PMT9312_0210.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB49272 ; ABB49272 ; PMT9312_0210 .
    GeneIDi 3764995.
    KEGGi pmi:PMT9312_0210.
    PATRICi 23004038. VBIProMar70153_0214.

    Phylogenomic databases

    eggNOGi COG0148.
    HOGENOMi HOG000072174.
    KOi K01689.
    OMAi RSEIKGQ.
    OrthoDBi EOG65J589.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00187 .
    BioCyci PMAR74546:GHRG-215-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPi MF_00318. Enolase.
    InterProi IPR000941. Enolase.
    IPR020810. Enolase_C.
    IPR029065. Enolase_C-like.
    IPR020809. Enolase_CS.
    IPR020811. Enolase_N.
    IPR029017. Enolase_N_like.
    [Graphical view ]
    PANTHERi PTHR11902. PTHR11902. 1 hit.
    Pfami PF00113. Enolase_C. 1 hit.
    PF03952. Enolase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001400. Enolase. 1 hit.
    PRINTSi PR00148. ENOLASE.
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsi TIGR01060. eno. 1 hit.
    PROSITEi PS00164. ENOLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9312.

    Entry informationi

    Entry nameiENO_PROM9
    AccessioniPrimary (citable) accession number: Q31CX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3