Q31CU8 (PYRB_PROM9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	PMT9312_0235

Organism

Prochlorococcus marinus (strain MIT 9312) [Complete proteome] [HAMAP]

Taxonomic identifier

74546 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321136

Sequences

	Sequence		Length	Mass (Da)
	Q31CU8 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: D8EED0A8FFA28ABE	FASTA	339	37,524
	10 20 30 40 50 60 MQTIWPHKHI HTLANFSIQD YKSVFELAHR FDVLKNAGTK KIPALQGTLV TSLFFEASTR 70 80 90 100 110 120 TKNSFELAAK RLSADVQTFA PSSSSLTKGE TIIDTALTYS AMGADTLVIR HSSSYITFEI 130 140 150 160 170 180 AKKLDAINAK TSVLNAGDGL HSHPSQGLLD IYTLIKFFSK KSLSPDVLNS KKILIIGDVN 190 200 210 220 230 240 HSRVARSNLW ALSAFGADII LCGPKTLIPD EFINFLKTPA PKQKEDPVKS RGSITISRSL 250 260 270 280 290 300 EESIKIADAI IVLRLQKERM MENLLSSIDS YSLDYGLTPE KLSLNSKEIP ILHPGPINRG 310 320 330 IEITSKVVDE YPNCLINNQV ANGIPIRMAL LYLLQKYNK

References

[1]

"Complete sequence of Prochlorococcus marinus str. MIT 9312." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9312.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000111 Genomic DNA. Translation: ABB49297.1.
RefSeq	YP_396733.1. NC_007577.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ProteinModelPortal	Q31CU8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q31CU8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3765020.
GenomeReviews	Gene locus PMT9312_0235 in contig CP000111_GR.
KEGG	pmi:PMT9312_0235.
PATRIC	23004090. VBIProMar70153_0240.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q31CU8.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	PMAR74546:PMT9312_0235-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_PROM9

Accession

Primary (citable) accession number: Q31CU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 6, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program