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Q31BX5 (GLO2_PROM9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hydroxyacylglutathione hydrolase
EC=3.1.2.6
Alternative name(s):
Glyoxalase II
Short name=Glx II
Gene names
Name:gloB
Ordered Locus Names:PMT9312_0559
OrganismProchlorococcus marinus (strain MIT 9312) [Complete proteome] [HAMAP]
Taxonomic identifier74546 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374

Subunit structure

Monomer By similarity. HAMAP MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Hydroxyacylglutathione hydrolase HAMAP MF_01374
PRO_0000309679

Sites

Metal binding581Zinc 1 By similarity
Metal binding601Zinc 1 By similarity
Metal binding621Zinc 2 By similarity
Metal binding631Zinc 2 By similarity
Metal binding1171Zinc 1 By similarity
Metal binding1371Zinc 1 By similarity
Metal binding1371Zinc 2 By similarity
Metal binding1751Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q31BX5 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 4BAA42AFD489E2FC

FASTA24628,515
        10         20         30         40         50         60 
MEFNKAQNII GLRVLNDNVI WLWEKDKSVV VIDPAIHEPV IRYIDENNLY IKAILQTHHH 

        70         80         90        100        110        120 
SDHIGGTKYL IERWPNVQVI ASSKDKKRIP FQNISVEDGE TLNILGEEIK IIEVLGHTNS 

       130        140        150        160        170        180 
HIAFFVNGES PVLFIGDTLF SGGCGRIFEG TYQQMYSSLE RIKSLPKNTL IYCAHEYTKA 

       190        200        210        220        230        240 
NLLWALNLKP KDQDIKNKLL QVEKKLSINE LTIPFLLDEE MKINLFLRAK NLKEFTFLRE 


NKDLWV

« Hide

References

[1]"Complete sequence of Prochlorococcus marinus str. MIT 9312."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9312.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000111 Genomic DNA. Translation: ABB49620.1.
RefSeqYP_397056.1. NC_007577.1.

3D structure databases

ProteinModelPortalQ31BX5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ31BX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3765358.
GenomeReviewsGene locus PMT9312_0559 in contig CP000111_GR.
KEGGpmi:PMT9312_0559.
PATRIC23004796. VBIProMar70153_0579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0491.
HOGENOMHBG753931.
OMAITHHHRD.
PhylomeDBQ31BX5.
ProtClustDBCLSK921893.

Enzyme and pathway databases

BioCycPMAR74546:PMT9312_0559-MONOMER.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
[Tree]
InterProIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
KOK01069.
PANTHERPTHR11935:SF7. PTHR11935:SF7. 1 hit.
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLO2_PROM9
AccessionPrimary (citable) accession number: Q31BX5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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